Headache Medicine
Tension-Type Headache
Diagnose tension-type headache clinically after screening for secondary-headache red flags, distinguish episodic from chronic disease by monthly headache frequency, limit acute analgesic exposure, and reserve preventive strategies for chronic burden or recurrent treatment failure.
First Decision
Exclude secondary headache before labeling a tension-type phenotype
A typical recurrent pattern without red flags supports a positive diagnosis rather than routine exclusionary testing.
Escalate beyond a primary-headache assessment when the history or examination identifies systemic symptoms or illness, fever, HIV or other immunocompromise, focal neurologic signs, sudden or thunderclap onset, onset at older age, or a substantive change in the established headache pattern. These SNOOP features warrant targeted urgent evaluation and usually neuroimaging rather than empiric treatment as uncomplicated tension-type headache. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It
Treat papilledema, rash or neck stiffness, cough- or exertion-triggered headache, pregnancy or postpartum headache, and a patient's worst headache as red flags. Select imaging and additional emergency workup according to the suspected process; the actionable point is that these features should interrupt a routine primary-headache pathway. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It
In the absence of red flags and with a stable compatible clinical pattern, make a positive diagnosis and explain the diagnosis and management plan; routine investigation solely to exclude alternative pathology is not required. nice org uk+1nice org ukHeadaches in over 12s: diagnosis and managementnice org ukHeadaches in over 12s: diagnosis and management - NICE
Perform and document a neurologic examination and funduscopic assessment when possible; papilledema changes the pathway to secondary-headache evaluation. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It
Reassess the diagnosis when headache frequency, phenotype, associated symptoms, or examination findings change rather than assuming progression of a prior tension-type disorder. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It
| Clinical finding | Interpretation | Next action |
|---|---|---|
| Fever, systemic illness, rash, HIV, or other systemic symptoms | SNOOP systemic red flag. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It | Evaluate for the relevant infectious, inflammatory, or systemic cause rather than managing as isolated tension-type headache. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It |
| Focal neurologic sign or papilledema | Neurologic red flag. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It | Obtain urgent secondary-headache assessment and neuroimaging as clinically indicated. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It |
| Thunderclap or sudden onset; "worst headache" | Onset-pattern red flag. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It | Use an urgent acute-headache pathway rather than outpatient analgesic management. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It |
| New onset at older age or marked pattern change | Age and pattern-change red flags. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It | Investigate for secondary pathology before assigning a primary headache diagnosis. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It |
| Pregnancy/postpartum, neck stiffness, or cough/exertion trigger | Additional concerning features. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It | Perform condition-directed evaluation; do not presume a benign primary headache. ajnrajnrHeadache and Neuroimaging: Why We Continue to Do It |
Phenotype and Frequency
Classify headache frequency and identify medication overuse
Monthly headache frequency and acute-medication exposure determine whether management should remain episodic or shift to chronic-headache care.
Document headache days per month and duration of the current frequency pattern. Tension-type headache is episodic at fewer than 15 headache days per month and chronic at 15 or more days per month for more than 3 months. This threshold identifies patients in whom recurrent acute treatment, disability assessment, and preventive options require explicit review. nice org uknice org ukHeadaches in over 12s: diagnosis and management
At every headache visit, count days of use—not simply tablets—for acetaminophen, NSAIDs, aspirin-containing products, combination analgesics, opioids, triptans, and ergot derivatives. Medication-overuse headache is defined by regular use for more than 3 months on at least 15 days per month for simple analgesics, including paracetamol or NSAIDs, or at least 10 days per month for triptans, ergotamines, opioids, or combination analgesics. Wolters KluwerWolters KluwerSmoking and medication-overuse headache : Cephalalgia
A patient with escalating headache days and threshold-level acute medication use should be managed as possible medication-overuse headache superimposed on a primary headache disorder, rather than by simply increasing rescue medication. Provide explicit counseling about medication-overuse risk whenever acute treatment is used. nice org uk+1nice org ukHeadaches in over 12s: diagnosis and managementnice org ukHeadaches in over 12s: diagnosis and management - NICE
Ask specifically about nonprescription products and caffeine-containing combination analgesics; combination analgesics carry the lower, 10-days-per-month overuse threshold. Wolters KluwerWolters KluwerSmoking and medication-overuse headache : Cephalalgia
Do not infer a tension-type diagnosis solely from pain location or perceived muscle tension when the headache pattern has changed or acute-medication exposure is high. Wolters Kluwer+1Wolters KluwerSmoking and medication-overuse headache : CephalalgiaajnrHeadache and Neuroimaging: Why We Continue to Do It
Acute Care
Use simple analgesics early and avoid opioids
Acute treatment selection should match comorbidities, adverse-effect risk, and the patient's monthly exposure count.
For short-term treatment of tension-type headache, use ibuprofen 400 mg or acetaminophen 1000 mg as supported options. Choose ibuprofen only after considering NSAID-related risk, and choose acetaminophen with attention to the patient's total exposure from all products. acpjournalsacpjournals2023 U.S. Department of Veterans Affairs and ...
Aspirin, paracetamol/acetaminophen, or an NSAID may be considered for acute tension-type headache, with selection based on patient preference, comorbidities, and risk of adverse events. Do not offer aspirin-containing preparations to patients younger than 16 years because of the association with Reye syndrome. nice org uk+2nice org ukNATIONAL INSTITUTE FOR HEALTH AND CLINICAL ...nice org ukHeadaches in over 12s: diagnosis and managementnice org ukHeadaches in over 12s: diagnosis and management - NICE
Do not prescribe opioids for acute tension-type headache. Opioids also meet the lower medication-overuse threshold of at least 10 treatment days per month when used regularly for more than 3 months. Wolters Kluwer+2Wolters KluwerSmoking and medication-overuse headache : Cephalalgianice org ukNATIONAL INSTITUTE FOR HEALTH AND CLINICAL ...nice org ukHeadaches in over 12s: diagnosis and management
Before issuing a refill or recommending repeated over-the-counter treatment, record current acute-treatment days per month and compare them with medication-overuse thresholds. Wolters KluwerWolters KluwerSmoking and medication-overuse headache : Cephalalgia
If the phenotype is migrainous rather than tension-type, do not continue a tension-type pathway; migraine acute treatment recommendations include an oral triptan combined with an NSAID or paracetamol/acetaminophen. nice org uk+1nice org ukNATIONAL INSTITUTE FOR HEALTH AND CLINICAL ...nice org ukHeadaches in over 12s: diagnosis and management - NICE
When the clinical phenotype is not tension-type
Primary headache management depends on accurate phenotype assignment. For migraine with or without aura, guideline recommendations favor oral triptan plus an NSAID or oral triptan plus paracetamol/acetaminophen, rather than treating repeated attacks as tension-type headache. nice org uk+1nice org ukNATIONAL INSTITUTE FOR HEALTH AND CLINICAL ...nice org ukHeadaches in over 12s: diagnosis and management - NICE
Chronic Disease
Address chronic tension-type headache with prevention and exposure reduction
Chronic frequency requires a structured review of medication use, diagnostic stability, and preventive options.
For chronic tension-type headache, consider a course of up to 10 acupuncture sessions delivered over 5 to 8 weeks as preventive treatment. This option is specifically recommended for the chronic frequency category, not merely for occasional episodic attacks. nice org uk+1nice org ukHeadaches in over 12s: diagnosis and managementnice org ukHeadaches in over 12s: diagnosis and management - NICE
If chronic headache coexists with regular acute-medication use at medication-overuse thresholds, address the overuse directly. Continued use of simple analgesics on at least 15 days per month, or combination analgesics, opioids, triptans, or ergotamines on at least 10 days per month, sustains a medication-overuse diagnostic pattern after more than 3 months of exposure. Wolters KluwerWolters KluwerSmoking and medication-overuse headache : Cephalalgia
Use a headache diary to capture headache days, acute-medication days by class, and change in headache phenotype. A rising frequency, a new neurologic symptom, or development of secondary-headache red flags should trigger diagnostic reassessment rather than automatic escalation of preventive care. ajnr+1ajnrHeadache and Neuroimaging: Why We Continue to Do Itnice org ukHeadaches in over 12s: diagnosis and management
Set a follow-up interval sufficient to review a complete monthly diary and identify whether acute-treatment exposure is approaching medication-overuse thresholds. Wolters KluwerWolters KluwerSmoking and medication-overuse headache : Cephalalgia
Reevaluate patients with chronic headache for coexisting migraine or medication-overuse headache because chronic headache disorders commonly include chronic migraine, chronic tension-type headache, and medication-overuse headache. BMJ+1BMJThe lived experience of chronic headache: a systematic review ...BMJThe lived experience of chronic headache
References
- Tricyclic antidepressants and headaches: systematic review and meta-analysis | The BMJ — www.bmj.com · www.bmj.com
- The lived experience of chronic headache: a systematic review ... — bmjopen.bmj.com · bmjopen.bmj.com
- The lived experience of chronic headache — bmjopen.bmj.com · bmjopen.bmj.com
- study protocol for a randomised controlled trial — bmjopen.bmj.com · bmjopen.bmj.com
- Practice advisory for intravenous management of ... — rapm.bmj.com · rapm.bmj.com
- 2023 U.S. Department of Veterans Affairs and ... — www.acpjournals.org · www.acpjournals.org
- Headache in stroke. — www.ahajournals.org · www.ahajournals.org
- 2024 American Heart Association and American Red ... — www.ahajournals.org · www.ahajournals.org
- Onset Headache Predicts Good Outcome in Patients With ... — www.ahajournals.org · www.ahajournals.org
- Migraine — www.acpjournals.org · www.acpjournals.org
- Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients — www.nature.com · www.nature.com
- Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis | Scientific Reports — www.nature.com · www.nature.com
- Is painful temporomandibular disorder a real headache for many patients? | British Dental Journal — www.nature.com · www.nature.com
- ARTICLE IN PRESS — www.nature.com · www.nature.com
- Abstracts - IANCON 2024 : Annals of Indian Academy ... — journals.lww.com · journals.lww.com
- Spinal nociceptive sensitization and plasma... : Pain — journals.lww.com · journals.lww.com
- Smoking and medication-overuse headache : Cephalalgia — journals.lww.com · journals.lww.com
- Medication-Overuse Headache | Continuum — journals.lww.com · journals.lww.com
- Headache and Neuroimaging: Why We Continue to Do It — www.ajnr.org · www.ajnr.org
- Headache Care | Pediatrics In Review — publications.aap.org · publications.aap.org
- NATIONAL INSTITUTE FOR HEALTH AND CLINICAL ... — www.nice.org.uk · www.nice.org.uk
- Headaches in over 12s: diagnosis and management — www.nice.org.uk · www.nice.org.uk
- Headaches in over 12s: diagnosis and management - NICE — www.nice.org.uk · www.nice.org.uk
- 4-year surveillance (2016) — www.nice.org.uk · www.nice.org.uk