Pediatric emergency medicine
Pediatric Dehydration Rehydration
Select oral rehydration for most children with mild-to-moderate dehydration, use nasogastric ORS when drinking fails, and reserve isotonic intravenous fluid for shock, deterioration, altered mental status, ileus, or failed enteral therapy.
Initial decision
Choose the rehydration route from perfusion, mentation, and enteral tolerance
Route selection should be made before calculating a replacement regimen.
Use ORS for infants and children with mild-to-moderate dehydration who can protect the airway and tolerate enteral administration. ORS is recommended until clinical dehydration resolves; after correction, continue maintenance fluids and replace stool losses with ORS until vomiting and diarrhea stop. The Lancet+1The LancetOral rehydration for children with gastroenteritis - The LancetIDSAInfectious Diarrhea - IDSA
Use isotonic intravenous fluid—lactated Ringer's solution or 0.9% sodium chloride—when severe dehydration, shock, altered mental status, ileus, or failed ORS therapy is present. Continue intravenous resuscitation until pulse, perfusion, and mental status normalize and the child is awake without aspiration risk; then replace the remaining deficit enterally with ORS. IDSAIDSAInfectious Diarrhea - IDSA
For a child with clinical dehydration who cannot drink sufficient ORS or vomits persistently, administer ORS through a nasogastric tube if shock is absent. Escalate to intravenous therapy when vomiting persists despite oral or nasogastric ORS, when clinical deterioration occurs despite ORS, or when shock is suspected or confirmed. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
Do not use enteral rehydration as the sole initial strategy in shock, altered mental status, ileus, or an aspiration-risk state. IDSAIDSAInfectious Diarrhea - IDSA
Do not continue an ineffective ORS trial in a child with red-flag deterioration; switch to intravenous fluid therapy. nice org uknice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Reintroduce oral rehydration early during intravenous therapy; if tolerated, stop intravenous fluids and complete rehydration enterally. nice org uknice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Enteral treatment
Deliver oral rehydration over 4 hours and replace ongoing losses
Use a commercially prepared glucose-electrolyte ORS rather than nonstandard fluids.
For a child with clinical dehydration due to gastroenteritis, give 50 mL/kg of ORS plus maintenance volume over 4 hours. Administer frequent small amounts rather than large boluses, and reassess clinically during the rehydration interval. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
A physiologically appropriate ORS contains 70 to 90 mEq/L sodium and no more than 25 g/L glucose. Do not substitute fruit juice or carbonated beverages for ORS during active rehydration; these fluids are specifically excluded from the recommended supplementation options. publications aap+1publications aapDehydration (Chapter 353) | Pediatric Care Online - AAP Publicationsnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
Continue breastfeeding and other milk feeds after rehydration. For children at increased risk of recurrent dehydration—including those younger than 1 year, particularly younger than 6 months; those with low birth weight; more than five watery stools in 24 hours; or more than two vomiting episodes in 24 hours—consider 5 mL/kg ORS after each large watery stool. nice org uknice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Measure weight before treatment when feasible, and obtain complete vital signs before initiating an ORS pathway. acepacepPediatric Oral Rehydration Therapy (ORT) | Pediatric Emergency Medicine
Use frequent small oral volumes by spoon, syringe, or caregiver-administered dosing when this improves acceptance. acepacepOral Rehydration Therapy | Pediatric Emergency Medicine
If enteral intake remains inadequate after a structured oral trial, use nasogastric ORS or intravenous fluid according to clinical severity. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
When vomiting limits oral rehydration
Consider a single oral ondansetron dose of 0.2 mg/kg when vomiting is a barrier to ORS in the emergency setting. The purpose is to enable enteral rehydration, not to replace reassessment for shock, altered mental status, or failure of fluid intake. acepacepOral Rehydration Therapy | Pediatric Emergency Medicine
Resuscitation
Resuscitate shock with isotonic fluid, then transition promptly to enteral therapy
In shock, restore circulation before deficit completion.
For suspected or confirmed shock associated with gastroenteritis, give 0.9% sodium chloride 10 mL/kg as a rapid intravenous infusion. If shock persists after the first infusion, immediately repeat 0.9% sodium chloride 10 mL/kg and reassess the response. nice org uknice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
In severe dehydration, continue intravenous rehydration until pulse, peripheral perfusion, and mental status normalize and the child awakens without aspiration risk or ileus. At that point, use ORS to replace the remaining deficit rather than continuing intravenous fluid solely for completion of rehydration. IDSAIDSAInfectious Diarrhea - IDSA
Obtain serum sodium, potassium, creatinine, blood urea, and glucose in hospitalized children when electrolyte or renal complications may affect fluid planning. Electrolyte testing helps classify dehydration as isotonic, hyponatremic, or hypernatremic, a distinction that changes fluid planning. Wiley+1WileyEuropean Society for Pediatric Gastroenterology, Hepatology, and ...ScienceDirectDehydration Syndromes: Oral Rehydration and Fluid Replacement - ScienceDirect
Use isotonic IV solutions for severe dehydration, shock, altered mental status, failed ORS, or ileus. IDSAIDSAInfectious Diarrhea - IDSA
Reassess pulse, perfusion, mental status, ability to drink, aspiration risk, and evidence of ileus after each resuscitative step. IDSAIDSAInfectious Diarrhea - IDSA
During IV therapy, attempt early gradual ORS; discontinue IV fluid and complete rehydration orally when tolerated. nice org uknice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Hypernatremic dehydration
Hypernatremic dehydration requires a fluid plan that avoids rapid sodium correction. Initial parenteral hydration uses isotonic fluid, followed by a slightly hypotonic solution for slow correction; sodium-free glucose solution should not be used to rapidly lower serum sodium. ScienceDirectScienceDirectOral Rehydration Therapy - an overview
Use serum sodium to identify hypernatremic, isotonic, or hyponatremic dehydration before finalizing replacement strategy in hospitalized children. ScienceDirectScienceDirectDehydration Syndromes: Oral Rehydration and Fluid Replacement - ScienceDirect
Reassessment
Use response to rehydration to determine escalation, discharge, and ongoing replacement
The therapeutic response is a serial clinical assessment, not a one-time route choice.
Monitor the response to ORS by repeated clinical assessment. Deterioration despite appropriately delivered ORS, inability to retain oral or nasogastric ORS, or evolution of shock should trigger intravenous fluid therapy rather than extending an unsuccessful enteral trial. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
After clinical rehydration, maintain fluid intake and replace continuing stool losses with ORS until diarrhea and vomiting resolve. Continue breastfeeding and other milk feeds; children at high risk for recurrent dehydration may receive 5 mL/kg ORS after each large watery stool. IDSA+1IDSAInfectious Diarrhea - IDSAnice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Use a bedside glucose measurement as part of an emergency department ORS assessment pathway. In a child with ketonemia, an initial intravenous hydration course may be needed to permit later oral rehydration tolerance. acep+1acepOral Rehydration Therapy | Pediatric Emergency MedicineIDSAInfectious Diarrhea - IDSA
Discharge planning requires a child who is clinically rehydrated and able to continue ORS and usual feeds outside the monitored setting. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA
Provide a specific ongoing-loss plan rather than advising unrestricted free-water intake: ORS is the recommended replacement fluid for ongoing stool losses. IDSAIDSAInfectious Diarrhea - IDSA
For children requiring hospitalization or IV therapy, include sodium, potassium, creatinine, blood urea, and glucose when results will direct fluid planning or identify complications. Wiley+1WileyEuropean Society for Pediatric Gastroenterology, Hepatology, and ...ScienceDirectDehydration Syndromes: Oral Rehydration and Fluid Replacement - ScienceDirect
Common questions
When should nasogastric ORS be used instead of intravenous fluid?
Use nasogastric ORS when a clinically dehydrated child cannot drink adequate ORS or persistently vomits but does not have shock. Escalate to IV fluid if nasogastric ORS is persistently vomited or the child deteriorates. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
Which IV fluid should be used when pediatric dehydration requires parenteral treatment?
Use isotonic fluid—0.9% sodium chloride or lactated Ringer's solution—for severe dehydration, shock, altered mental status, ileus, or ORS failure. For gastroenteritis-associated shock, NICE specifies rapid 0.9% sodium chloride 10 mL/kg, repeated once immediately if shock persists. nice org uk+1nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA
References
- Oral rehydration for children with gastroenteritis - The Lancet — www.thelancet.com · www.thelancet.com
- Assessing safety and efficacy of a novel glucose-free amino acid ... — www.thelancet.com · www.thelancet.com
- Oral Ondansetron for Gastroenteritis in a Pediatric Emergency ... — www.nejm.org · www.nejm.org
- European Society for Pediatric Gastroenterology, Hepatology, and ... — onlinelibrary.wiley.com · onlinelibrary.wiley.com
- Fluid management in hospitalized pediatric patients - ASPEN Journals — aspenjournals.onlinelibrary.wiley.com · aspenjournals.onlinelibrary.wiley.com
- ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ... — onlinelibrary.wiley.com · onlinelibrary.wiley.com
- Ketonuria - an overview | ScienceDirect Topics — www.sciencedirect.com · www.sciencedirect.com
- Dehydration Syndromes: Oral Rehydration and Fluid Replacement - ScienceDirect — www.sciencedirect.com · www.sciencedirect.com
- Comparison of ultrarapid and rapid intravenous hydration in pediatric patients with dehydration - ScienceDirect — www.sciencedirect.com · www.sciencedirect.com
- Oral Rehydration Therapy - an overview — www.sciencedirect.com · www.sciencedirect.com
- Re: Nasogastric Rehydration In Acute Gastroenteritis - Yiu - 2003 — onlinelibrary.wiley.com · onlinelibrary.wiley.com
- Cochrane review: Oral versus intravenous rehydration for treating ... — onlinelibrary.wiley.com · onlinelibrary.wiley.com
- Recommendations for research | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE — www.nice.org.uk · www.nice.org.uk
- Recommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE — www.nice.org.uk · www.nice.org.uk
- [PDF] Diarrhoea and vomiting: full guideline - NICE — www.nice.org.uk · www.nice.org.uk
- [PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE — www.nice.org.uk · www.nice.org.uk
- Pediatric hydration therapy: Historical review and a new approach — www.kidney-international.org · www.kidney-international.org
- Pediatric Oral Rehydration Therapy (ORT) | Pediatric Emergency Medicine — www.acep.org · www.acep.org
- Oral Rehydration Therapy | Pediatric Emergency Medicine — www.acep.org · www.acep.org
- Infectious Diarrhea - IDSA — www.idsociety.org · www.idsociety.org
- Oral versus intravenous rehydration for treating dehydration due to ... — www.cochranelibrary.com · www.cochranelibrary.com
- Diarrhea and Oral Rehydration Therapy - ACEP — www.acep.org · www.acep.org
- Index of Suspicion | Pediatrics In Review - AAP Publications — publications.aap.org · publications.aap.org
- Dehydration (Chapter 353) | Pediatric Care Online - AAP Publications — publications.aap.org · publications.aap.org