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Pediatric emergency medicine

Pediatric Dehydration Rehydration

Select oral rehydration for most children with mild-to-moderate dehydration, use nasogastric ORS when drinking fails, and reserve isotonic intravenous fluid for shock, deterioration, altered mental status, ileus, or failed enteral therapy.

Clinical question: How should clinicians select and monitor oral, nasogastric, or intravenous rehydration for dehydrated children?

Initial decision

Choose the rehydration route from perfusion, mentation, and enteral tolerance

Route selection should be made before calculating a replacement regimen.

Use ORS for infants and children with mild-to-moderate dehydration who can protect the airway and tolerate enteral administration. ORS is recommended until clinical dehydration resolves; after correction, continue maintenance fluids and replace stool losses with ORS until vomiting and diarrhea stop. The LancetOral rehydration for children with gastroenteritis - The LancetIDSAInfectious Diarrhea - IDSA

Use isotonic intravenous fluid—lactated Ringer's solution or 0.9% sodium chloride—when severe dehydration, shock, altered mental status, ileus, or failed ORS therapy is present. Continue intravenous resuscitation until pulse, perfusion, and mental status normalize and the child is awake without aspiration risk; then replace the remaining deficit enterally with ORS. IDSAInfectious Diarrhea - IDSA

For a child with clinical dehydration who cannot drink sufficient ORS or vomits persistently, administer ORS through a nasogastric tube if shock is absent. Escalate to intravenous therapy when vomiting persists despite oral or nasogastric ORS, when clinical deterioration occurs despite ORS, or when shock is suspected or confirmed. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE

Route selection for pediatric dehydration. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA
Clinical branchPreferred routeImmediate action and reassessment
Mild-to-moderate dehydration; safe enteral intakeOral ORSGive ORS until clinical dehydration corrects; reassess clinically during therapy. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA
Cannot drink enough ORS or persistent vomiting without shockNasogastric ORSUse nasogastric ORS; move to IV fluid if ORS is persistently vomited or deterioration occurs. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE
Severe dehydration, shock, altered mental status, ileus, or failed ORSIsotonic IV fluidContinue until pulse, perfusion, and mental status normalize; then complete remaining deficit with ORS when safe. IDSAInfectious Diarrhea - IDSA

Enteral treatment

Deliver oral rehydration over 4 hours and replace ongoing losses

Use a commercially prepared glucose-electrolyte ORS rather than nonstandard fluids.

For a child with clinical dehydration due to gastroenteritis, give 50 mL/kg of ORS plus maintenance volume over 4 hours. Administer frequent small amounts rather than large boluses, and reassess clinically during the rehydration interval. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE

A physiologically appropriate ORS contains 70 to 90 mEq/L sodium and no more than 25 g/L glucose. Do not substitute fruit juice or carbonated beverages for ORS during active rehydration; these fluids are specifically excluded from the recommended supplementation options. publications aapDehydration (Chapter 353) | Pediatric Care Online - AAP Publicationsnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE

Continue breastfeeding and other milk feeds after rehydration. For children at increased risk of recurrent dehydration—including those younger than 1 year, particularly younger than 6 months; those with low birth weight; more than five watery stools in 24 hours; or more than two vomiting episodes in 24 hours—consider 5 mL/kg ORS after each large watery stool. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE

Practical ORS regimen and post-rehydration replacement. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICEpublications aapDehydration (Chapter 353) | Pediatric Care Online - AAP Publications
SituationORS actionWhat changes management
Clinical dehydration from gastroenteritis50 mL/kg plus maintenance over 4 hours, in frequent small amounts. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICERegular clinical reassessment determines whether enteral therapy is succeeding or IV escalation is needed. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Child cannot drink sufficient ORSAdminister ORS through a nasogastric tube. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICEPersistent vomiting of oral or nasogastric ORS warrants IV therapy. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
After rehydration with high risk of recurrent lossesConsider 5 mL/kg ORS after every large watery stool. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEUse this strategy particularly in infants, low-birth-weight children, and children with frequent stool or emesis losses. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE

When vomiting limits oral rehydration

Consider a single oral ondansetron dose of 0.2 mg/kg when vomiting is a barrier to ORS in the emergency setting. The purpose is to enable enteral rehydration, not to replace reassessment for shock, altered mental status, or failure of fluid intake. acepOral Rehydration Therapy | Pediatric Emergency Medicine

Resuscitation

Resuscitate shock with isotonic fluid, then transition promptly to enteral therapy

In shock, restore circulation before deficit completion.

For suspected or confirmed shock associated with gastroenteritis, give 0.9% sodium chloride 10 mL/kg as a rapid intravenous infusion. If shock persists after the first infusion, immediately repeat 0.9% sodium chloride 10 mL/kg and reassess the response. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE

In severe dehydration, continue intravenous rehydration until pulse, peripheral perfusion, and mental status normalize and the child awakens without aspiration risk or ileus. At that point, use ORS to replace the remaining deficit rather than continuing intravenous fluid solely for completion of rehydration. IDSAInfectious Diarrhea - IDSA

Obtain serum sodium, potassium, creatinine, blood urea, and glucose in hospitalized children when electrolyte or renal complications may affect fluid planning. Electrolyte testing helps classify dehydration as isotonic, hyponatremic, or hypernatremic, a distinction that changes fluid planning. WileyEuropean Society for Pediatric Gastroenterology, Hepatology, and ...ScienceDirectDehydration Syndromes: Oral Rehydration and Fluid Replacement - ScienceDirect

Intravenous escalation and transition checkpoints. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA
FindingFluid actionEndpoint or next action
Suspected or confirmed shock0.9% sodium chloride 10 mL/kg rapid IV infusion. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIf shock remains, immediately repeat 10 mL/kg of 0.9% sodium chloride. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Severe dehydration with altered mental status, ileus, or failed ORSUse isotonic IV fluid. IDSAInfectious Diarrhea - IDSAContinue until pulse, perfusion, and mental status normalize and enteral safety is restored. IDSAInfectious Diarrhea - IDSA
Stable during IV therapy and tolerating ORSIntroduce ORS early and gradually. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEStop IV fluid and complete rehydration enterally if ORS is tolerated. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE

Hypernatremic dehydration

Hypernatremic dehydration requires a fluid plan that avoids rapid sodium correction. Initial parenteral hydration uses isotonic fluid, followed by a slightly hypotonic solution for slow correction; sodium-free glucose solution should not be used to rapidly lower serum sodium. ScienceDirectOral Rehydration Therapy - an overview

Reassessment

Use response to rehydration to determine escalation, discharge, and ongoing replacement

The therapeutic response is a serial clinical assessment, not a one-time route choice.

Monitor the response to ORS by repeated clinical assessment. Deterioration despite appropriately delivered ORS, inability to retain oral or nasogastric ORS, or evolution of shock should trigger intravenous fluid therapy rather than extending an unsuccessful enteral trial. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE

After clinical rehydration, maintain fluid intake and replace continuing stool losses with ORS until diarrhea and vomiting resolve. Continue breastfeeding and other milk feeds; children at high risk for recurrent dehydration may receive 5 mL/kg ORS after each large watery stool. IDSAInfectious Diarrhea - IDSAnice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE

Use a bedside glucose measurement as part of an emergency department ORS assessment pathway. In a child with ketonemia, an initial intravenous hydration course may be needed to permit later oral rehydration tolerance. acepOral Rehydration Therapy | Pediatric Emergency MedicineIDSAInfectious Diarrhea - IDSA

Response-based monitoring after rehydration begins. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA
Reassessment findingInterpretationNext step
Pulse, perfusion, and mental status normalize; child awakens and has no aspiration risk or ileusIV resuscitation endpoint reached. IDSAInfectious Diarrhea - IDSAComplete remaining deficit with ORS and maintain enteral fluids. IDSAInfectious Diarrhea - IDSA
Persistent vomiting of oral or nasogastric ORSEnteral rehydration has failed. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEUse intravenous fluid therapy. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Clinical deterioration despite ORSHigher-acuity dehydration or another process must be assumed. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEEscalate to IV therapy and reassess for shock. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICE
Ongoing watery stool losses after rehydrationRisk of recurrent volume depletion. IDSAInfectious Diarrhea - IDSAReplace losses with ORS; consider 5 mL/kg after each large watery stool in high-risk children. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA

Common questions

When should nasogastric ORS be used instead of intravenous fluid?

Use nasogastric ORS when a clinically dehydrated child cannot drink adequate ORS or persistently vomits but does not have shock. Escalate to IV fluid if nasogastric ORS is persistently vomited or the child deteriorates. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEnice org uk[PDF] Diarrhoea and vomiting caused by gastroenteritis in under 5s - NICE

Which IV fluid should be used when pediatric dehydration requires parenteral treatment?

Use isotonic fluid—0.9% sodium chloride or lactated Ringer's solution—for severe dehydration, shock, altered mental status, ileus, or ORS failure. For gastroenteritis-associated shock, NICE specifies rapid 0.9% sodium chloride 10 mL/kg, repeated once immediately if shock persists. nice org ukRecommendations | Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management | Guidance | NICEIDSAInfectious Diarrhea - IDSA

References

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  2. Assessing safety and efficacy of a novel glucose-free amino acid ...www.thelancet.com · www.thelancet.com
  3. Oral Ondansetron for Gastroenteritis in a Pediatric Emergency ...www.nejm.org · www.nejm.org
  4. European Society for Pediatric Gastroenterology, Hepatology, and ...onlinelibrary.wiley.com · onlinelibrary.wiley.com
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