Amphetamine toxicity is a clinical sympathomimetic emergency requiring rapid recognition of hyperthermia, agitation, seizures, cardiovascular ischemia or dysrhythmia, rhabdomyolysis, and co-ingestion, followed by targeted monitoring and escalation for organ-specific complications.

First Minutes

Identify patients needing resuscitation and monitored care

Prioritize physiologic threats over confirmation of the exposure.

Place patients with altered mental status, severe agitation, hyperthermia, seizure, chest pain, dyspnea, syncope, marked blood-pressure abnormality, or suspected mixed ingestion in a monitored setting. Amphetamine overdose can produce tachyarrhythmias, hypertension or hypotension, circulatory collapse, vasospasm, myocardial infarction, aortic dissection, Takotsubo cardiomyopathy, seizures, stroke, coma, and rhabdomyolysis. accessdata fda+2accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII

Measure core temperature promptly when feasible in a patient with agitation, diaphoresis, rigidity, seizure, or depressed consciousness. Temperature greater than 104°F is identified in FDA labeling as life-threatening hyperthermia and should trigger immediate active cooling and evaluation for rhabdomyolysis and end-organ injury. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII ScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics

Assess airway protection, ventilation, circulation, glucose, mental status, and trauma at presentation. Do not attribute coma, focal neurologic deficit, persistent chest pain, shock, or a focal infectious syndrome solely to stimulant exposure; amphetamine-associated cerebral vascular accidents, cardiac ischemia, endocarditis in people injecting drugs, and bloodstream or bone/joint infections require disease-specific evaluation. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf PubMedMethamphetamine Toxicities and Clinical Management - PMC

Call Poison Help at 1-800-222-1222 or consult a medical toxicologist for individualized overdose management, particularly with severe toxicity, prolonged symptoms, uncertain formulation, or suspected polysubstance exposure. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov fda[PDF] Adzenys Labeling - FDA accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII fda[PDF] Mydayis Labeling - FDA
Do not rely on dialysis for amphetamine elimination: d-amphetamine is not dialyzable. accessdata fda+2accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII
Avoid urine acidification as an elimination strategy; although it may increase excretion of some amphetamine derivatives, it may worsen renal toxicity when rhabdomyolysis is present. ScienceDirectScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics

Immediate findings that should redirect care toward a specific complication. accessdata fda+5accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII ScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf PubMedMethamphetamine Toxicities and Clinical Management - PMC
Presentation	Immediate concern	Next diagnostic action
Core temperature >104°F	Life-threatening hyperthermia; rhabdomyolysis and organ injury	Initiate active cooling; obtain CK, chemistry studies, and urinalysis. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Chest pain, dyspnea, syncope, abnormal rhythm, or unstable blood pressure	Vasospasm, myocardial infarction, dysrhythmia, cardiomyopathy, aortic dissection, or circulatory collapse	Obtain ECG; add cardiac biomarkers and cardiopulmonary imaging based on presentation. accessdata fda+5accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment \| BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Seizure, coma, focal deficit, or persistent delirium	Seizure-related injury, stroke, intracranial process, or co-ingestion	Check glucose and pursue neurologic evaluation rather than assuming uncomplicated intoxication. accessdata fda+2accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII
Hyperthermia, prolonged agitation, seizure, muscle pain, weakness, or dark urine	Rhabdomyolysis and acute kidney injury	Obtain CK, comprehensive chemistry panel, and urinalysis; trend abnormalities according to severity. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Diagnostic Branching

Use targeted testing to detect toxicity complications

Testing is driven by clinical severity and the organ system at risk.

Amphetamine toxicity is diagnosed clinically from exposure history, toxidrome, serial vital signs, mental-status examination, and complication screening. Patients may not disclose recent methamphetamine use, and the differential diagnosis of sympathomimetic findings is broad; obtain urine toxicology as an adjunct when it will clarify exposure or competing causes, not as the sole basis for diagnosis or disposition. BMJ+2BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

For moderate or severe presentations, obtain a CBC, comprehensive chemistry panel, CK, and urinalysis to identify renal dysfunction, electrolyte disturbance, and muscle injury. Add troponin for chest pain, dyspnea, concerning ECG findings, or suspected myocardial injury; BNP can assist when acute heart failure or methamphetamine-associated cardiomyopathy is suspected. PubMed+1PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf PubMedMethamphetamine Toxicities and Clinical Management - PMC

Obtain a 12-lead ECG for cardiovascular symptoms, hemodynamic instability, marked tachycardia, or suspected co-ingestion. When clinical findings suggest ischemia or structural cardiac disease, use serial cardiac assessment and imaging directed by the presentation; amphetamine exposure has been associated with vasospasm, myocardial infarction, aortic dissection, Takotsubo cardiomyopathy, and tachyarrhythmia. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII NEJMMyocardial Infarction after Inhalation of Methamphetamine PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Consider blood or urine gas chromatography/mass spectrometry when definitive identification is clinically important, such as an unclear exposure with major medicolegal, diagnostic, or treatment implications. BMJ+1BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US
Obtain chest radiography when respiratory or cardiopulmonary findings warrant it; chest x-ray is among investigations used selectively in amphetamine toxicity. BMJ+1BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US
With injection exposure plus fever, murmur, embolic findings, or focal bone/joint symptoms, evaluate for endovascular, bloodstream, or musculoskeletal infection rather than attributing illness to intoxication. PubMed+1PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf PubMedMethamphetamine Toxicities and Clinical Management - PMC

Targeted initial investigations for suspected clinically significant amphetamine toxicity. BMJ+3BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf PubMedMethamphetamine Toxicities and Clinical Management - PMC
Test	Who needs it	What an abnormal result changes
ECG	Chest pain, dyspnea, syncope, hemodynamic instability, significant tachycardia, or suspected dysrhythmia	Identifies ischemic or rhythm abnormalities requiring cardiac-directed management and monitoring. accessdata fda+5accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment \| BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Troponin	Chest pain, ischemic ECG changes, dyspnea, or suspected myocardial injury	Supports evaluation for myocardial injury in a patient at risk for vasospasm, infarction, or cardiomyopathy. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
CBC and comprehensive chemistry panel	Moderate or severe toxicity, hyperthermia, seizure, prolonged agitation, or altered mental status	Detects renal dysfunction and metabolic abnormalities that affect disposition and organ-supportive management. BMJ+2BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment \| BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
CK and urinalysis	Hyperthermia, seizure, muscle symptoms, prolonged agitation, or concern for rhabdomyolysis	Identifies muscle injury and renal involvement requiring serial assessment. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Urine toxicology	Uncertain exposure or broad sympathomimetic differential	Supports exposure assessment but must be interpreted with clinical findings and exposure history. BMJ+2BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment \| BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Differentiate intoxication from serotonin syndrome

Amphetamine products can precipitate serotonin syndrome, particularly with concomitant serotonergic drugs or CYP2D6 inhibitors. The actionable pattern is mental-status change plus autonomic instability and neuromuscular findings such as tremor, rigidity, myoclonus, hyperreflexia, or incoordination; seizures and gastrointestinal symptoms may occur. Stop the amphetamine and concomitant serotonergic agents immediately and institute supportive symptomatic treatment when this syndrome is suspected. accessdata fdaaccessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII

Interpret exposure history by formulation and route

Ask specifically about prescribed immediate-release or extended-release products, nonmedical tablets or powders, methamphetamine, MDMA-related compounds, route of use, timing, and co-ingestants. Amphetamines may be swallowed, insufflated, smoked, or injected; extended-release pharmacokinetics should be considered during overdose management, and amphetamine products should not be converted milligram-for-milligram because salt compositions differ. accessdata fda+2accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov fda[PDF] Adzenys Labeling - FDA BMJAmphetamine overdose - Symptoms, diagnosis and ...

Management Priorities

Treat hyperthermia, neurologic toxicity, and cardiovascular injury as separate emergencies

Disposition and monitoring follow the most severe complication, not the reported dose.

Escalate care for hyperthermia, seizure, coma, persistent severe agitation, dysrhythmia, ischemic symptoms, circulatory instability, or rhabdomyolysis. Hyperthermia can occur independently of seizures and is associated with rhabdomyolysis, coagulopathy, renal failure, and death; cooling and reassessment for organ injury take priority over attempts to enhance drug elimination. ScienceDirect+1ScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics WileyPharmacology of Drugs Used as Stimulants - Wiley Online Library

In a patient with severe agitation, hallucinations, paranoia, or delirium, evaluate for co-ingestion, hypoglycemia, hyperthermia, trauma, infection, and neurologic disease while reducing risk to the patient and staff. Methamphetamine-related psychosis is associated with dose, duration of use, preexisting vulnerability to psychosis, and possibly sleep deprivation; persistent or atypical symptoms warrant psychiatric and medical reassessment rather than presuming a transient intoxication state. PubMedPubMedMethamphetamine Toxicities and Clinical Management - PMC

For chest pain or hemodynamic instability, manage as a potential cardiovascular emergency rather than as uncomplicated anxiety. Amphetamine toxicity can produce hypertension or hypotension, tachyarrhythmia, vasospasm, myocardial infarction, aortic dissection, Takotsubo cardiomyopathy, and circulatory collapse; ECG, biomarkers, repeated examinations, and syndrome-directed imaging should determine escalation. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII NEJMMyocardial Infarction after Inhalation of Methamphetamine PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Monitor renal function, electrolytes, CK, and urine findings when rhabdomyolysis is suspected; acute kidney injury is a recognized complication of severe stimulant toxicity. ScienceDirect+1ScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Evaluate seizures, focal deficits, or coma for cerebrovascular complications and other structural causes because cerebral vascular accidents and coma occur in amphetamine overdose. accessdata fda+2accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII
When managing possible mixed overdose, account for multiple drug ingestion; amphetamine toxicity may coexist with sedatives, opioids, serotonergic agents, or other stimulants. accessdata fda+2accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII

Complication-based escalation in amphetamine toxicity. accessdata fda+5accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII ScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf PubMedMethamphetamine Toxicities and Clinical Management - PMC
Dominant complication	Monitoring focus	Escalation trigger
Hyperthermia	Core temperature, mental status, CK, renal function, urinalysis	Temperature >104°F, worsening mental status, seizure, or laboratory evidence of rhabdomyolysis/renal injury. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII ScienceDirectCocaine Intoxication - an overview \| ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Cardiovascular toxicity	Continuous rhythm assessment, blood pressure, ECG, cardiac biomarkers when indicated	Persistent chest pain, ischemic ECG change, dysrhythmia, syncope, shock, or concern for dissection/cardiomyopathy. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Neurologic or psychiatric toxicity	Serial mental status, temperature, glucose, seizure activity, trauma screen	Seizure, coma, focal deficit, uncontrolled agitation, or persistent psychosis after immediate medical causes are assessed. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII PubMedMethamphetamine Toxicities and Clinical Management - PMC
Rhabdomyolysis or renal injury	CK, creatinine, electrolytes, urinalysis, urine output	Worsening renal function, electrolyte abnormality, or progressive muscle injury. ScienceDirect+1ScienceDirectCocaine Intoxication - an overview \| ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Medication-related and interaction risks

For prescribed amphetamine products, concurrent MAOI use is contraindicated, including linezolid or intravenous methylene blue, and a 14-day interval after stopping an MAOI is required because of hypertensive-crisis risk. In suspected serotonin syndrome, stop the amphetamine and all concomitant serotonergic agents immediately. accessdata fda+3accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov fda[PDF] Adzenys Labeling - FDA accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII fda[PDF] Mydayis Labeling - FDA

Do not substitute one amphetamine product for another on a milligram-per-milligram basis during medication reconciliation or overdose estimation because amphetamine salt compositions differ. fdafda[PDF] Adzenys Labeling - FDA
Consider prolonged or delayed toxicity when an extended-release product is involved; product pharmacokinetics affect observation and overdose assessment. accessdata fdaaccessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov

Disposition

Base observation and admission on complications and formulation

A reported exposure amount is less informative than trajectory, formulation, and organ injury.

Continue observation until mental status, temperature, vital signs, and cardiovascular findings show a sustained favorable trajectory and no evolving complication is identified. Extend monitoring when exposure involves an extended-release formulation, when history is unreliable, or when agitation, hyperthermia, abnormal ECG findings, elevated troponin, rising CK, renal injury, or recurrent symptoms persist. accessdata fda+3accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Admit patients requiring ongoing monitoring for hyperthermia, rhabdomyolysis, renal dysfunction, seizure, persistent delirium or psychosis, dysrhythmia, ischemic symptoms, heart failure findings, or hemodynamic instability. ICU-level care is appropriate when airway protection, active temperature control, invasive hemodynamic support, or continuous management of severe neurologic or cardiovascular complications is required. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII ScienceDirectCocaine Intoxication - an overview | ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf

Before discharge after a nonsevere presentation, reconcile all prescribed and nonprescribed stimulants, screen for co-occurring psychiatric illness and substance use disorder, and arrange addiction-focused follow-up when nonmedical stimulant use is identified. Diagnosis of amphetamine or methamphetamine use disorder is clinical, and treatment planning should account for co-occurring psychiatric conditions and recurrent use or relapse. BMJ+1BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US

Document route, formulation, timing, estimated dose, co-ingestants, and whether the exposure was intentional, therapeutic, accidental, or related to nonmedical use; these details change recurrence prevention and anticipated duration of toxicity. accessdata fda+2accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov fda[PDF] Adzenys Labeling - FDA BMJAmphetamine overdose - Symptoms, diagnosis and ...
For abrupt cessation after chronic CNS-stimulant exposure, anticipate extreme fatigue and depression; distinguish withdrawal from persistent intoxication or an emerging psychiatric disorder. fdafda[PDF] Mydayis Labeling - FDA

Disposition considerations after suspected amphetamine toxicity. accessdata fda+4accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov fda[PDF] Mydayis Labeling - FDA BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice US PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Clinical trajectory	Disposition implication	Required next step
Resolved symptoms with stable serial vital signs and no detected complication	Observation discharge may be considered	Provide exposure-specific counseling, medication reconciliation, and follow-up for substance-use or psychiatric needs. BMJ+1BMJAmphetamine and methamphetamine use disorder BMJAmphetamine and methamphetamine use disorder - Symptoms, diagnosis and treatment \| BMJ Best Practice US
Extended-release exposure or uncertain timing	Need longer observation because pharmacokinetics may affect overdose course	Use formulation history and serial clinical reassessment rather than a single early examination. accessdata fda+1accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov fda[PDF] Adzenys Labeling - FDA
Abnormal ECG, troponin elevation, renal injury, elevated CK, hyperthermia, seizure, or persistent altered mental status	Hospital admission	Continue organ-specific monitoring and treatment. accessdata fda+4accessdata fda[PDF] Warnings: Abuse, Misuse, and Addiction. - accessdata.fda.gov accessdata fda[PDF] highlights of prescribing information - accessdata.fda.gov accessdata fda[PDF] DESOXYN (methamphetamine hydrochloride tablets), for oral use, CII ScienceDirectCocaine Intoxication - an overview \| ScienceDirect Topics PubMedMethamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf
Extreme fatigue and depression after abrupt stimulant cessation	Assess for withdrawal and psychiatric risk	Evaluate mood symptoms and safety rather than interpreting all symptoms as ongoing intoxication. fdafda[PDF] Mydayis Labeling - FDA

Amphetamine Toxicity