{ "schemaVersion": 2, "eyebrow": "Emergency Toxicology", "title": "Sympathomimetic Toxicity", "summary": "Recognize the hyperadrenergic syndrome early, stabilize agitation and hyperthermia with GABAergic sedation and cooling, then selectively investigate cardiac, neurologic, renal, and muscle complications that determine monitored versus critical-care disposition.", "seoDescription": "Point-of-care approach to sympathomimetic toxicity: stabilization, targeted testing, hyperthermia, agitation, cardiovascular complications, and disposition.", "clinicalQuestion": "How should physicians stabilize, evaluate, and disposition patients with acute sympathomimetic toxicity?", "specialty": "Emergency Medicine and Medical Toxicology", "audience": "U.S. physicians and medical trainees", "tags": [ "sympathomimetic toxidrome", "stimulant intoxication", "methamphetamine toxicity", "cocaine toxicity", "amphetamine overdose", "hyperthermia", "agitated delirium" ], "keyTakeaways": [ "Treat clinically apparent sympathomimetic toxicity immediately; benzodiazepines are first-line for neuroexcitation and hyperadrenergic manifestations. [14][21]", "Hyperthermia, severe agitation, seizures, chest pain, rhabdomyolysis, acute kidney injury, and intracranial hemorrhage identify patients needing emergency investigation and treatment. [2][13]", "Use ECG and cardiac biomarkers when chest pain, concerning cardiovascular findings, or heavy/long-term stimulant exposure raises concern for ischemia or dysrhythmia. [2][17][18]", "Lower the threshold for CK testing in patients with heavy stimulant exposure or examination findings concerning for rhabdomyolysis; assess renal injury concurrently. [18]", "Toxicology testing is useful only when it changes management, such as differentiating stimulant-associated psychosis from primary psychiatric decompensation or evaluating possible pediatric exposure. [18]" ], "sections": [ { "id": "initial-stabilization", "eyebrow": "First Minutes", "heading": "Stabilize hyperadrenergic toxicity before confirming the exposure", "intro": "Escalate care according to agitation, temperature, neurologic status, and end-organ injury rather than the reported substance.", "paragraphs": [ "Use an ABC assessment and immediately obtain temperature, heart rate, blood pressure, respiratory status, and serial mental-status examinations. The clinically useful syndrome is autonomic hyperactivity—tachycardia, hypertension, diaphoresis, and mydriasis—with psychomotor agitation, paranoia, psychosis, seizure, or hyperthermia. Continue vital-sign monitoring, particularly heart rate and blood pressure, because untreated hyperadrenergic physiology can produce complications. [1][21]", "Place patients with significant hyperadrenergic manifestations in an acute-care setting. Remove further exposure, minimize stimulation in a quiet area when feasible, and treat neuroexcitation and autonomic instability rather than attempting to establish a specific stimulant diagnosis before treatment. [14][19][21]", "Administer a GABAergic agent for stimulant-related hyperadrenergic symptoms; benzodiazepines are the recommended first-line class and also address agitation and seizures. Phenobarbital or propofol are GABAergic alternatives in appropriate monitored settings. The search results support lorazepam 2 mg orally as one cited option for stimulant intoxication, but do not establish a universal intravenous dosing regimen; titrate the sedative strategy to clinical control with respiratory monitoring. [19][21]" ], "bullets": [ "Treat seizures as a toxicologic emergency with benzodiazepines; do not defer treatment for toxicology confirmation. [19][21]", "Start active cooling when hyperthermia is present; cooling is a core first-line measure alongside benzodiazepines for sympathomimetic toxicity. [14]", "Escalate immediately for severe agitation, hyperthermia, chest pain, seizure, focal neurologic findings, declining consciousness, or evidence of rhabdomyolysis or acute kidney injury. [2][13]" ], "subsections": [], "table": { "caption": "Immediate features that change the initial care setting and diagnostic priority. [2][13][21]", "columns": [ "Presentation", "Immediate action", "Priority complication" ], "rows": [ [ "Marked agitation, paranoia, or psychosis with tachycardia or hypertension", "Continuous vital-sign observation; benzodiazepine-first GABAergic treatment in an acute-care setting. [21]", "Persistent hyperadrenergic injury or stimulant-associated psychosis. [18][21]" ], [ "Hyperthermia", "Initiate cooling and control neuroexcitation with benzodiazepines. [14][21]", "Severe systemic toxicity requiring emergency treatment. [2][13]" ], [ "Seizure or depressed consciousness", "Treat seizure with benzodiazepines; repeat neurologic and respiratory assessment. [19]", "Intracranial hemorrhage, co-ingestion, aspiration, or recurrent seizure. [13][19]" ], [ "Chest pain or clinically concerning cardiovascular findings", "Obtain ECG and cardiac biomarkers as indicated. [2]", "Myocardial ischemia or dysrhythmia. [17][20]" ], [ "Myalgias, rigidity, prolonged agitation, or heavy stimulant exposure", "Obtain CK with renal assessment; maintain heightened suspicion for rhabdomyolysis and renal injury. [18]", "Rhabdomyolysis and acute kidney injury. [13][18]" ] ] } }, { "id": "focused-diagnostic-workup", "eyebrow": "Diagnostic Branching", "heading": "Target testing to end-organ toxicity and meaningful alternatives", "intro": "The toxidrome directs treatment; tests determine complications, co-ingestions, and alternative diagnoses.", "paragraphs": [ "Obtain point-of-care glucose when altered mental status, seizure, or an uncertain toxidrome makes hypoglycemia a competing diagnosis. In patients with suspected stimulant toxicity, blood chemistries, ECG, cardiac biomarkers, chest radiography, and definitive blood or urine testing may be indicated according to the presentation rather than ordered routinely. [2][19]", "For chest pain, ischemic ECG changes, dysrhythmia, persistent hemodynamic abnormalities, or substantial stimulant exposure, obtain an ECG and cardiac biomarkers. Cocaine can cause coronary vasoconstriction while increasing cardiac workload; ECG alone may not establish ischemia, whereas cardiac troponins improve diagnostic clarity. Cocaine also increases dysrhythmia risk, including ventricular tachycardia, and may prolong QRS and QT through sodium- and potassium-channel effects. [17][20][24]", "For methamphetamine-associated presentations, consider CBC, comprehensive chemistry panel, troponin, BNP, CK, and urinalysis when the presentation suggests cardiac, renal, or muscle injury. In long-term or heavy stimulant use, maintain heightened suspicion for cardiac and renal disorders, use a lower threshold for ECG, and use a lower threshold for CK when history or examination suggests rhabdomyolysis. [15][18]" ], "bullets": [ "Obtain chest radiography in coma or respiratory compromise when aspiration pneumonia is a concern. [19]", "Interpret QRS or QTc abnormalities as a clue to cardiotoxic co-ingestion rather than as a defining finding of uncomplicated stimulant intoxication. [19]", "Do not use urine toxicology merely to confirm an obvious stimulant toxidrome if the result will not alter care. [18]", "Use comprehensive toxicology testing when the result changes a high-consequence decision, including suspected pediatric exposure or distinction between stimulant-associated psychosis and primary psychiatric decompensation. [18]" ], "subsections": [ { "heading": "Neurologic and psychiatric branch", "paragraphs": [ "Agitated delirium, hallucinations, paranoia, confusion, and formication can occur with cocaine and other stimulants, but focal deficits, persistent depressed consciousness, severe headache, or seizure should redirect evaluation toward intracranial pathology, including hemorrhage. Methamphetamine toxicity may present with seizures and intracranial hemorrhage; serial neurologic assessment is therefore a disposition-critical part of reassessment after initial sedation. [13][19]" ], "bullets": [ "If neurologic findings fail to improve as hyperadrenergic activity is controlled, pursue an alternative neurologic diagnosis rather than attributing persistent deficits to intoxication alone. [13][19]" ] }, { "heading": "Muscle and renal branch", "paragraphs": [ "Order CK and renal studies when prolonged agitation, hyperthermia, weakness, or other clinical features raise concern for rhabdomyolysis. A normal initial appearance should not eliminate concern in heavy stimulant use: ASAM/AAAP recommends a lower threshold for CK testing and heightened suspicion for renal disorders based on history and examination. [13][18]" ], "bullets": [ "Use serial clinical reassessment and renal monitoring when CK elevation, renal dysfunction, or ongoing hyperthermia is identified. [13][18]" ] } ], "table": { "caption": "Testing should answer a complication or differential-diagnosis question, not simply document exposure. [2][18][19]", "columns": [ "Clinical trigger", "Test", "Result that changes next action" ], "rows": [ [ "Altered mental status or seizure with uncertain cause", "Point-of-care glucose. [19]", "Hypoglycemia redirects immediate management away from isolated stimulant toxicity. [19]" ], [ "Chest pain, ischemic symptoms, dysrhythmia, or significant cardiovascular findings", "ECG and cardiac biomarkers. [2][17]", "Ischemic or conduction findings require cardiac-focused monitoring and evaluation. [17][20]" ], [ "Heavy/long-term stimulant exposure or concerning examination", "ECG; consider CK and renal evaluation. [18]", "Abnormal ECG, rhabdomyolysis, or renal injury increases monitoring and disposition needs. [18]" ], [ "Coma or respiratory compromise", "Chest radiograph. [19]", "Aspiration pneumonia becomes a competing or coexisting diagnosis. [19]" ], [ "Psychosis with uncertain stimulant exposure or possible pediatric ingestion", "Comprehensive toxicology testing when clinically consequential. [18]", "Clarifies a diagnosis or exposure scenario that changes safety and diagnostic decisions. [18]" ] ] } }, { "id": "cardiovascular-and-temperature-complications", "eyebrow": "Complication Management", "heading": "Treat cardiovascular and thermal injury as end-organ toxicity", "intro": "Persistent abnormalities after sedation require focused evaluation for ischemic, electrical, vascular, and systemic injury.", "paragraphs": [ "Treat agitation and autonomic activation first with a benzodiazepine-centered GABAergic strategy, then reassess heart rate, blood pressure, temperature, chest pain, and ECG. This sequence matters because psychomotor agitation and catecholaminergic activation are major drivers of the tachycardia and hypertension seen with sympathomimetic agents. [1][14][21]", "Do not dismiss chest pain because the patient is young or reports cocaine use. Cocaine-associated myocardial ischemia can occur in young men without major atherosclerosis, although risk is greater with atherosclerosis and cigarette smoking. Cocaine also roughly doubles the risk of ischemic and hemorrhagic stroke and is associated with aortic dissection; chest, back, or neurologic symptoms therefore require organ-specific evaluation rather than reassurance after initial sedation. [17]", "For methamphetamine, consider both acute ischemic/electrical complications and chronic structural disease. In one retrospective cohort, only 28.3% of methamphetamine users had a normal ECG; QTc greater than 440 ms occurred in 27.2%, and a retrospective analysis of 627 ECGs found evidence of myocardial infarction in 6.5%. These data support a low threshold for ECG in high-risk presentations but do not replace symptom- and examination-directed interpretation. [20][18]" ], "bullets": [ "Avoid relying on a single ECG to exclude cocaine-related ischemia when clinical concern remains; integrate serial clinical assessment and cardiac biomarkers. [17]", "Monitor temperature carefully in stimulant toxicity; ketamine may potentiate cocaine cardiovascular toxicity. [8]", "Consider co-ingestion when the clinical picture includes nystagmus, marked coma, atypical respiratory depression, or QRS/QTc abnormalities. Nystagmus can occur with ethanol, benzodiazepines, anticonvulsants, ketamine, dextromethorphan, phencyclidine, and serotonin syndrome. [1][19]" ], "subsections": [ { "heading": "Beta-blocker controversy", "paragraphs": [ "Recommendations in the cited literature differ. A cocaine intoxication overview advises avoiding beta-blocking agents because of concern for unopposed alpha-adrenergic effects, whereas an archived methamphetamine review reports no published cases of unopposed alpha stimulation with beta-blocker treatment and notes that the historical dogma arose from seven cocaine cases. In an acutely hyperadrenergic patient, prioritize benzodiazepine-centered treatment and obtain toxicology or cardiovascular consultation before selecting a beta-blocker strategy for persistent instability. [12][15][21]" ], "bullets": [] } ], "table": { "caption": "Features that should prevent attribution of all findings to uncomplicated intoxication. [13][17][19][20]", "columns": [ "Finding", "Complication to prioritize", "Next diagnostic action" ], "rows": [ [ "Chest pain, ischemic symptoms, or concerning ECG", "Coronary ischemia or stimulant-related dysrhythmia. [17][20]", "ECG and cardiac biomarkers; continue cardiac-focused reassessment. [2][17]" ], [ "Neurologic deficit, severe headache, seizure, or persistent altered consciousness", "Intracranial hemorrhage or other neurologic pathology. [13][17]", "Repeat neurologic examinations and evaluate for intracranial disease. [13][19]" ], [ "Hyperthermia with severe agitation", "Escalating systemic toxicity and rhabdomyolysis. [13][14]", "Cooling, benzodiazepine-centered control, CK, and renal assessment. [14][18]" ], [ "Prolonged QRS or QTc", "Cardiotoxic co-ingestion or stimulant-related conduction toxicity. [19][20]", "Review exposures and maintain ECG-based monitoring. [19]" ] ] } }, { "id": "disposition-and-aftercare", "eyebrow": "Disposition", "heading": "Disposition after physiologic control and complication screening", "intro": "Disposition should follow repeated reassessment, not the initial degree of agitation alone.", "paragraphs": [ "Continue acute-care monitoring until the hyperadrenergic state is controlled and the trajectory of temperature, heart rate, blood pressure, neurologic status, and any identified cardiac, renal, or muscle complication is clear. Significant hyperadrenergic symptoms typically require acute-care management, and serial vital signs are specifically recommended to reduce preventable complications. [21]", "Use a higher level of care when severe agitation requires ongoing sedative treatment, hyperthermia persists, seizures recur, chest pain or ECG/troponin findings suggest cardiac injury, neurologic findings raise concern for hemorrhage, or CK/renal testing identifies rhabdomyolysis or acute kidney injury. These presentations are specifically identified among the serious complications of methamphetamine and stimulant toxicity. [2][13][18]", "After acute stabilization, assess co-occurring psychiatric conditions and offer treatment for stimulant use disorder. Contingency management, cognitive behavioral therapy, motivational interviewing, the Matrix model, and community reinforcement are core treatment approaches; pharmacotherapy evidence remains limited and is generally considered in specialist care settings. [2]" ], "bullets": [ "Do not treat a positive toxicology test as a substitute for evaluating chest pain, seizure, focal deficits, hyperthermia, or renal injury. [2][13][18]", "When psychosis is present, determine whether symptoms resolve with intoxication treatment and use toxicology testing selectively when distinguishing stimulant-associated psychosis from primary psychiatric decompensation changes management. [18]", "For recurrent presentations or chronic use, maintain suspicion for cardiomyopathy, heart failure, hypertension, ischemia, and injection-related endocarditis when symptoms or examination suggest those diagnoses. [15][23]" ], "subsections": [], "table": { "caption": "Disposition anchors after initial control of the toxidrome. [2][13][18][21]", "columns": [ "Clinical course", "Disposition implication", "Required reassessment" ], "rows": [ [ "Persistent hyperthermia, severe agitation, or recurrent seizure", "Continue acute-care management and consider critical-care escalation. [2][13][21]", "Serial temperature, neurologic status, respiratory status, and vital signs. [19][21]" ], [ "Chest pain, abnormal ECG, or elevated cardiac biomarkers", "Cardiac-focused monitored evaluation. [2][17]", "Symptoms, ECG, and cardiac biomarker trajectory. [2][17]" ], [ "CK elevation, renal dysfunction, or suspected rhabdomyolysis", "Ongoing monitoring for renal and muscle complications. [13][18]", "Renal studies, CK, and clinical status. [18]" ], [ "Resolved hyperadrenergic findings with no identified end-organ complication", "Consider discharge only after repeated clinical reassessment and linkage to substance-use and psychiatric care. [2][21]", "Mental status, vital signs, and ability to engage in safe follow-up. [2][21]" ] ] } } ], "faq": [ { "question": "Should a urine drug screen be obtained in every suspected sympathomimetic toxidrome?", "answer": "No. Obtain toxicology testing when it changes a consequential decision, such as suspected pediatric exposure or distinguishing stimulant-associated psychosis from primary psychiatric illness; it is unnecessary to confirm an obvious toxidrome when treatment would be unchanged. [18]" }, { "question": "What ECG findings should raise concern for complications or co-ingestion?", "answer": "Ischemic changes, dysrhythmia, QRS prolongation, or QTc prolongation warrant cardiac-focused evaluation. QRS or QTc abnormalities may indicate cardiotoxic co-ingestion, while cocaine can impair conduction through sodium- and potassium-channel effects. 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CDC Stacks", "detail": "stacks.cdc.gov", "url": "https://stacks.cdc.gov/view/cdc/156927/cdc_156927_DS1.pdf", "authors": "stacks.cdc.gov", "host": "stacks.cdc.gov" }, { "number": 22, "title": "Common Substances of Abuse | Pediatrics In Review", "detail": "publications.aap.org", "url": "https://publications.aap.org/pediatricsinreview/article/39/8/403/31962/Common-Substances-of-Abuse", "authors": "publications.aap.org", "host": "publications.aap.org" }, { "number": 23, "title": "Methamphetamine‐related cardiovascular diseases - Schwarzbach", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.12572", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com" }, { "number": 24, "title": "Cocaine and cardiovascular toxicity - Wiley Online Library", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1080/1355621961000124676", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com" } ], "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "Toxidromes and a general approach to poisoning", "detail": "adc.bmj.com", "url": "https://adc.bmj.com/content/110/9/681", "authors": "adc.bmj.com", "host": "adc.bmj.com", "snippet": "Sympathomimetic or adrenergic agents include commonly misused substances such as amphetamines and cocaine; oral medications such as ephedrine and pseudoephedrine; and catecholamines such as epinephrine, norepinephrine and dopamine. The sympathomimetic toxidrome results from direct stimulation of adr", "score": 0.5735118 }, { "number": 2, "title": "Amphetamine and methamphetamine use disorder", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-us/201", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com", "snippet": "Diagnosis is based on clinical assessment. Further investigations such as blood chemistries, urine toxicology testing or blood or urine gas chromatography/mass spectrometry, ECG and cardiac blood markers, or chest x-ray may be indicated. Evaluation and management of co-occurring psychiatric conditio", "score": 0.33108783 }, { "number": 3, "title": "Amphetamine toxicity: Experience with 127 cases - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/pii/0736467989902631", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "# Selected topic Amphetamine toxicity: Experience with 127 cases. We present a retrospective study of 127 cases of amphetamine toxicity in an emergency department (ED). Toxic medical effects of amphetamine-related compounds seen in our patients are discussed. ### Cathinone, cocaine and methamphetami", "score": 0.5798055 }, { "number": 4, "title": "Comprehensive review of cardiovascular toxicity of drugs and ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/full/10.1002%2Fmed.21476", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine", "score": 0.5363378 }, { "number": 5, "title": "Antipsychotics for the treatment of sympathomimetic toxicity", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0735675719300014", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "### Ann Emerg Med\n\n### Adrenergic crisis from crack cocaine ingestion: report of five cases\n\n### J Emerg Med\n\n### Amphetamine toxicity: experience with 127 cases\n\n### J Emerg Med\n\n### Behavioral health trends in the United States: results from the 2014 National Survey on Drug Use and Health\n\n### Dru", "score": 0.51193684 }, { "number": 6, "title": "Human psychobiology of MDMA or 'Ecstasy': an overview of 25 ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/10.1002/hup.2318", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "Recreational stimulants such as cocaine, amphetamine, methamphetamine, and MDMA cause sympathomimetic activation (Parrott et al., 2004). With", "score": 0.5081298 }, { "number": 7, "title": "Substance Abuse and Violence - Wiley Online Library", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118832202.ch29", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "cocaine and methamphetamine are currently the most problematic and widespread sympathomimetics. Side effects of agitation, anxiety, and", "score": 0.5054935 }, { "number": 8, "title": "Poisoning with illicit substances: toxicology for the anaesthetist - Wong", "detail": "associationofanaesthetists-publications.onlinelibrary.wiley.com", "url": "https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.12053", "authors": "associationofanaesthetists-publications.onlinelibrary.wiley.com", "host": "associationofanaesthetists-publications.onlinelibrary.wiley.com", "snippet": "Being a potent sympathomimetic, ketamine can potentiate the cardiovascular toxicity of cocaine. Temperature should be carefully monitored.", "score": 0.4315129 }, { "number": 9, "title": "Mephedrone, compared with MDMA (ecstasy) and amphetamine ...", "detail": "bpspubs.onlinelibrary.wiley.com", "url": "https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01499.x", "authors": "bpspubs.onlinelibrary.wiley.com", "host": "bpspubs.onlinelibrary.wiley.com", "snippet": "Excessive intake of mephedrone leads to acute intoxication, displaying the clinical features of acute sympathomimetic toxidrome (Wood et al.,", "score": 0.33908364 }, { "number": 10, "title": "Protection against d-amphetamine toxicity - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/0735675790901945", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Elsevier logo\nThe American Journal of Emergency Medicine\n\n## The American Journal of Emergency Medicine\n\n## Published by: Elsevier\n\n### Published by\n\nElsevier\n\n# Original contribution Protection against d-amphetamine toxicity\n\n## Article preview\n\n## Abstract\n\n## Keywords\n\n## Organizational access\n\n#", "score": 0.3244071 }, { "number": 11, "title": "Psychostimulant use disorder and the heart - Ovid", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.14713", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "In all, psychostimulants present with a characteristic sympathomimetic toxidrome with a combination of effects on the heart and cardiovascular system which can.", "score": 0.24296416 }, { "number": 12, "title": "Cocaine Intoxication - an overview | ScienceDirect Topics", "detail": "sciencedirect.com", "url": "https://sciencedirect.com/topics/medicine-and-dentistry/cocaine-intoxication", "authors": "sciencedirect.com", "host": "sciencedirect.com", "snippet": "Elsevier logo\n\n# Cocaine Intoxication\n\nIn subject area: Medicine and Dentistry\n\nCocaine intoxication is defined as a state resulting from the use of cocaine, characterized by symptoms such as psychomotor agitation, dilated pupils, tachycardia, hypertension, hyperthermia, seizures, and other clinical", "score": 0.57723385 }, { "number": 13, "title": "Emergency department management of methamphetamine toxicity - PubMed", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/pubmed/37877728", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Title: Emergency department management of methamphetamine toxicity - PubMed\nAn official website of the United States government. **The .gov means it’s official.**. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal. The **https://** en", "score": 0.77548623 }, { "number": 14, "title": "Sympathomimetic Toxicity - StatPearls - NCBI Bookshelf", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/portal/utils/pageresolver.fcgi?recordid=6a084e257baa3e06c7b92a3b", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Title: Sympathomimetic Toxicity - StatPearls - NCBI Bookshelf\nAn official website of the United States government. The **https://** ensures that you are connecting to the. official website and that any information you provide is encrypted. # Sympathomimetic Toxicity. Stimulants have been prescribed ", "score": 0.7515939 }, { "number": 15, "title": "Methamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/portal/utils/pageresolver.fcgi?recordid=69ae1e551a63f1308cdc47a4", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Title: Methamphetamine Toxicity(Archived) - StatPearls - NCBI Bookshelf\nIn the United States, there were greater than 150,000 emergency department visits for toxicity from methamphetamine in 2011 based on data from the Substance Abuse and Mental Health Services Administration. Methamphetamine is a S", "score": 0.65359193 }, { "number": 16, "title": "Methamphetamine Toxicity - StatPearls - NCBI Bookshelf", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/books/NBK430895", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Methamphetamine is a highly addictive psychostimulant drug that is a derivative of amphetamine. Methamphetamine can produce euphoria and stimulant effects like those from other stimulants such as cocaine. In addition, methamphetamine is easily synthesized from inexpensive and readily obtainable chem", "score": 0.49831602 }, { "number": 17, "title": "Comprehensive review of cardiovascular toxicity of drugs and related agents", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6033155", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "8, of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medi", "score": 0.44174582 }, { "number": 18, "title": "The ASAM/AAAP Clinical Practice Guideline on the Management of ...", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11105801", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "signs and symptoms, clinicians should provide ongoing monitoring and management of vital signs—especially heart rate and blood pressure—to prevent complications that may result from untreated sympathomimetic toxicity. [...] 3. When evaluating patients with long-term or heavy stimulant use, clinici", "score": 0.28793845 }, { "number": 19, "title": "Clinical Practice Guidelines for Assessment and Management of ...", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10096213", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "Though cocaine and other stimulants have traditionally not been commonly abused in India, their use is gradually rising, especially in bigger cities. Presentation of cocaine intoxication is in the form of euphoric mood, increased psychomotor activity, severe agitation, impaired attention, auditory h", "score": 0.2744904 }, { "number": 20, "title": "Stimulant Drugs of Abuse and Cardiac Arrhythmias", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8766923", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "Methamphetamine and MDMA use increase risk of SCD in patients with pre-excitation syndromes103 and in patients with various cardiovascular diseases based on case reports.104 MDMA has been reported to provoke SCD in patients with channelopathies98 and electrical storm as a result of serotonin syndrom", "score": 0.27071258 }, { "number": 21, "title": "[PDF] The ASAM/AAAP Clinical Practice Guideline on the ... - CDC Stacks", "detail": "stacks.cdc.gov", "url": "https://stacks.cdc.gov/view/cdc/156927/cdc_156927_DS1.pdf", "authors": "stacks.cdc.gov", "host": "stacks.cdc.gov", "snippet": "for non-cardiovascular related symptoms.153 When assessing stimulant intoxication, clinicians should assess hyperadrenergic signs and symptoms, including tachycardia, hypertension, hyperthermia, and agitation. Ongoing monitoring and management of vital signs—especially heart rate and blood pressure—", "score": 0.6164054 }, { "number": 22, "title": "Common Substances of Abuse | Pediatrics In Review", "detail": "publications.aap.org", "url": "https://publications.aap.org/pediatricsinreview/article/39/8/403/31962/Common-Substances-of-Abuse", "authors": "publications.aap.org", "host": "publications.aap.org", "snippet": "Symptoms of sympathomimetic toxicity include agitation, hyperthermia, tachycardia, and hypertension. Typically, the amounts of these", "score": 0.5996498 }, { "number": 23, "title": "Methamphetamine‐related cardiovascular diseases - Schwarzbach", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.12572", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "MA consumption is associated with hypertension, acute and chronic myocardial toxicity, stroke, coronary artery disease, and sudden cardiac death", "score": 0.52962893 }, { "number": 24, "title": "Cocaine and cardiovascular toxicity - Wiley Online Library", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1080/1355621961000124676", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "At the same time cocaine is increasing the work-load on the heart it induces coronary artery vasoconstriction, potentially leading to cardiac ischemia.", "score": 0.4767995 } ], "publishedAt": "2026-09-16T00:10:01.558093+00:00", "updatedAt": "2026-09-16T00:10:01.558093+00:00", "readingMinutes": 6, "slug": "sympathomimetic-toxicity" }