{
"schemaVersion": 2,
"eyebrow": "Neurologic emergency",
"title": "Spinal Cord Compression",
"summary": "Spinal cord compression requires immediate localization, etiologic triage, and definitive decompression or oncologic treatment before neurologic injury becomes irreversible. In suspected malignant compression, urgent whole-spine contrast MRI, prompt corticosteroid use when neurologic involvement is present, and early spine-oncology coordination preserve ambulation and guide surgery versus radiotherapy.",
"seoDescription": "Physician guide to recognizing, imaging, and urgently managing spinal cord compression, including malignant, infectious, hemorrhagic, and degenerative causes.",
"clinicalQuestion": "How should physicians rapidly diagnose and triage spinal cord compression to preserve neurologic function?",
"specialty": "Neurology and Oncology",
"audience": "U.S. physicians and medical trainees",
"tags": [
"spinal cord compression",
"metastatic epidural spinal cord compression",
"MSCC",
"cauda equina syndrome",
"epidural abscess",
"spine emergency"
],
"keyTakeaways": [
"New myelopathy, bilateral neurologic symptoms, gait decline, sphincter dysfunction, or cancer-associated axial pain warrants urgent evaluation for cord or cauda equina compression.[18]",
"For suspected metastatic spinal cord compression, obtain whole-spine MRI with gadolinium urgently; MRI sensitivity and specificity are reported as 93% and 97%, respectively, and CT myelography is reserved for MRI contraindication or unavailability.[18]",
"In metastatic spinal cord compression with neurologic involvement, begin dexamethasone while arranging definitive management; high-dose regimens increase serious toxicity without clear neurologic benefit over standard dosing.[18]",
"Surgical decompression plus radiotherapy benefits selected patients with metastatic epidural compression, particularly with instability, bony compression, radioresistant disease, or a reasonable systemic prognosis.[17]",
"Do not assume cancer is the cause: epidural abscess, epidural hematoma, disc disease, traumatic instability, and degenerative myelopathy require different urgent interventions.[18]"
],
"sections": [
{
"id": "time-critical-triage",
"eyebrow": "First actions",
"heading": "Identify the phenotype that requires emergency imaging",
"intro": "Neurologic status at diagnosis is the dominant modifiable determinant of functional outcome.",
"paragraphs": [
"Treat suspected spinal cord or cauda equina compression as a time-sensitive syndrome rather than a diagnosis. Immediate concern is warranted for new focal or radicular spinal pain with progressive weakness, gait disturbance, sensory change, urinary retention or incontinence, fecal dysfunction, or a new sensory level. In cancer, back pain is the most common presenting symptom of metastatic spinal cord compression (MSCC), and motor deficits or sphincter dysfunction usually indicate more advanced disease.[18]",
"Cancer history substantially raises the pretest probability, but compression may be the first manifestation of malignancy. In patients without known cancer, symptoms suggesting compression plus constitutional features or otherwise unexplained persistent axial pain should prompt urgent investigation for malignancy as well as nonmalignant causes.[18]",
"Perform and document a focused neurologic examination before treatment when this does not delay stabilization: limb power, tone, reflexes, plantar responses, sensory level, gait when safe, perineal sensation, anal tone when clinically indicated, and postvoid residual when cauda equina dysfunction is suspected. A normal plain radiograph or absence of fever does not exclude epidural tumor, abscess, hematoma, or compressive disc disease.[18]"
],
"bullets": [
"Immediately assess airway and ventilatory status with high cervical lesions or rapidly progressive tetraparesis.[21]",
"Avoid unnecessary mobilization when instability is suspected; use positioning that minimizes spinal load while obtaining urgent specialist advice and imaging.[23]",
"Contact spine surgery/neurosurgery and the relevant etiologic service early: oncology for suspected MSCC, infectious diseases for suspected epidural abscess, and hematology/anesthesia/surgery for hematoma depending on context.[18]"
],
"subsections": [],
"table": {
"caption": "Clinical patterns that should alter immediate diagnostic and treatment priorities.[18]",
"columns": [
"Pattern",
"High-yield clues",
"Immediate priority"
],
"rows": [
[
"Metastatic epidural compression",
"Known cancer; progressive axial or radicular pain; myelopathy or cauda equina findings",
"Whole-spine contrast MRI; oncology and spine consultation; begin corticosteroid therapy when neurologic involvement is present.[18]"
],
[
"Spinal epidural abscess",
"Back pain with bacteremia risk, diabetes, injection drug use, immunosuppression, recent spinal procedure, or infection; fever may be absent",
"Urgent gadolinium-enhanced MRI, blood cultures, IV antimicrobials, and urgent surgical assessment if neurologic deficit or clinical instability.[18]"
],
[
"Spinal epidural hematoma",
"Acute pain and neurologic decline, particularly with anticoagulation or recent neuraxial procedure",
"Urgent MRI and surgical decompression for severe or progressive neurologic deficits.[18]"
],
[
"Traumatic or degenerative compression",
"Trauma, known stenosis, acute hyperextension injury, or progressive cervical myelopathy",
"CT for bony injury; MRI when cord, disc, hematoma, or ligamentous pathology will alter management.[14][21]"
]
]
}
},
{
"id": "imaging-and-diagnostic-pathway",
"eyebrow": "Diagnosis",
"heading": "Order the study that defines level, cause, and urgency",
"intro": "Imaging must define compression, tissue compartment, mechanical stability, and multiplicity.",
"paragraphs": [
"MRI of the whole spine with gadolinium is the preferred study for suspected MSCC because noncontiguous epidural disease can occur. For suspected MSCC, guidance supports MRI as soon as possible and within 24 hours; whole-spine sagittal T1 and T2 sequences with axial imaging through abnormalities help define metastases, epidural disease, and degree of neural compression.[9][23]",
"Use CT myelography when MRI is contraindicated or unavailable. CT is useful for vertebral destruction, collapse, retropulsion, and operative planning but is less sensitive than MRI for epidural soft tissue and cord pathology. Plain radiographs are inadequate to diagnose cord compression.[18][23]",
"For suspected spinal epidural abscess, obtain blood cultures and inflammatory markers while arranging MRI, but do not let laboratory testing delay imaging or surgical evaluation in a patient with neurologic deficit. Leukocytosis is absent in a substantial minority of cases; in one diagnostic study, ESR greater than 20 mm/hour plus one or more risk factors had high sensitivity but limited specificity for epidural abscess.[18]"
],
"bullets": [
"Image immediately for rapidly progressive deficit, conus/cauda equina syndrome, suspected hematoma, or high cervical compromise.[18]",
"For traumatic SCI, CT is the principal initial test for fracture and dislocation; MRI is useful when neurologic deficits are discordant with CT, soft-tissue injury is suspected, or operative planning requires definition of ongoing compression.[21]",
"Do not screen asymptomatic patients with known spinal metastases using MRI solely to detect MSCC; evidence reviewed by NICE did not show clinically important benefit from routine screening MRI in asymptomatic patients.[23]"
],
"subsections": [],
"table": {
"caption": "Imaging interpretation should trigger definitive action rather than merely confirm compression.[18][23]",
"columns": [
"Imaging result",
"Clinical consequence"
],
"rows": [
[
"Epidural tumor with cord or cauda equina compression",
"Initiate multidisciplinary MSCC pathway; assess neurologic deficit, radiosensitivity, stability, prognosis, and surgical candidacy.[17][23]"
],
[
"Vertebral collapse, retropulsed bone, deformity, or mechanical instability",
"Obtain urgent spine surgical input; stabilization and decompression may be needed rather than radiotherapy alone.[17][23]"
],
[
"Epidural abscess or phlegmon",
"Obtain cultures; begin IV antimicrobial therapy and pursue urgent decompression when neurologic compromise is present.[18]"
],
[
"Epidural hematoma",
"Urgent neurosurgical/spine surgical assessment; severe or progressive deficits generally require prompt evacuation.[18]"
]
]
}
},
{
"id": "malignant-compression",
"eyebrow": "Oncologic emergency",
"heading": "Manage metastatic epidural spinal cord compression",
"intro": "Preserving walking and continence requires parallel medical treatment, surgical assessment, and radiotherapy planning.",
"paragraphs": [
"MSCC most often arises from vertebral metastasis extending into the epidural space or from vertebral collapse. Thoracic involvement is most common. Pretreatment ambulatory function strongly predicts post-treatment ambulation; delayed diagnosis after loss of walking ability is associated with poor neurologic recovery.[11][18][20]",
"Give dexamethasone promptly for MSCC with neurologic signs or symptoms while definitive treatment is arranged. A commonly cited standard-dose regimen is a 10 mg IV bolus followed by 4 mg every 6 hours; high-dose strategies such as 96 mg daily are associated with psychosis, gastrointestinal ulceration or perforation, and other serious toxicity without demonstrated neurologic superiority over standard-dose treatment.[17][18] Monitor glucose and gastrointestinal risk, and taper after definitive treatment or when MSCC is excluded.[23]",
"Definitive treatment should be selected in a multidisciplinary discussion incorporating neurologic trajectory, epidural compression, mechanical stability, tumor radiosensitivity, performance status, systemic disease burden, anticipated survival, and patient goals. Prognostic and stability scores can structure assessment but should not determine treatment in isolation.[23]"
],
"bullets": [
"Favor urgent surgical evaluation for spinal instability, vertebral fragment displacement or bony compression, radioresistant tumor, need for tissue diagnosis, progression during radiotherapy, recurrence after prior radiotherapy, or potentially reversible neurologic decline in a patient fit for intervention.[17][23]",
"Radiotherapy is generally favored for radiosensitive histologies, patients not suitable for surgery, multilevel disease, or limited expected survival; myeloma and lymphoma are typically radiosensitive when instability or bony retropulsion is absent.[17][23]",
"For poor prognosis, short-course radiotherapy can reduce treatment burden; longer-course radiotherapy offers better local control for patients with longer expected survival in older comparative data.[17]"
],
"subsections": [
{
"heading": "Evidence for surgery plus radiotherapy",
"paragraphs": [
"In the randomized Patchell trial summarized in the CEPO review, direct decompressive surgery followed by radiotherapy preserved ambulation more often than radiotherapy alone (84% versus 57%) and prolonged median ambulatory duration (122 versus 13 days) in selected patients.[17] This evidence should not be generalized to patients excluded from the trial, including highly radiosensitive hematologic tumors or individuals unable to tolerate surgery.[17]"
],
"bullets": [
"Surgery is not synonymous with laminectomy alone; because many epidural metastases arise anteriorly from vertebral body disease, decompression and stabilization should address the actual compressive anatomy and mechanical instability.[11][17]"
]
}
],
"table": {
"caption": "Decision framework for MSCC definitive treatment.[17][23]",
"columns": [
"Predominant scenario",
"Typical strategy"
],
"rows": [
[
"High-grade compression with instability, bony retropulsion, or radioresistant disease in a surgical candidate",
"Decompression with stabilization as indicated, followed by postoperative radiotherapy after recovery.[17][23]"
],
[
"Radiosensitive tumor without instability or bony fragment compression",
"Corticosteroids when neurologically symptomatic, then urgent radiotherapy; systemic therapy may contribute for chemosensitive malignancies.[17]"
],
[
"Poor performance status or limited expected survival without a surgical indication",
"Rapid palliative radiotherapy when likely to provide symptom or function benefit; align intervention with goals of care.[17][23]"
],
[
"Complete paraplegia or tetraplegia for prolonged duration with controlled pain and poor prognosis",
"Radiotherapy may offer limited benefit; individualize decisions based on symptoms, disease biology, and goals.[23]"
]
]
}
},
{
"id": "nonmalignant-compression",
"eyebrow": "Do not miss",
"heading": "Treat abscess, hematoma, and traumatic compression as distinct emergencies",
"intro": "Etiology changes the immediate drug, procedural, and consultation pathway.",
"paragraphs": [
"Spinal epidural abscess is often diagnostically delayed because the classic combination of fever, pain, and neurologic deficit is uncommon early. Bacteremia risk, diabetes, injection drug use, immunosuppression, recent spinal intervention, or contiguous infection should lower the threshold for contrast-enhanced MRI. Management generally includes IV antimicrobial therapy and urgent decompression for neurologic deficit, sepsis, or failure of nonoperative management.[18]",
"Spinal epidural hematoma should be considered in acute spinal pain followed by weakness or sphincter dysfunction, particularly after neuraxial procedures or in patients receiving anticoagulants. Severe or progressive deficits require urgent surgical decompression; outcome worsens with delayed recognition.[18]",
"Acute traumatic compression requires spinal motion restriction, resuscitation, CT-based characterization of fracture or dislocation, and MRI when it informs decompression, disc/hematoma management, or ligamentous stability. Early decompression within 24 hours may improve neurologic outcomes and is recommended as an option when clinically feasible.[15][21]"
],
"bullets": [
"Obtain cultures before antibiotics for a stable suspected epidural abscess only when this will not delay therapy; do not defer antimicrobials or surgical evaluation in sepsis or neurologic decline.[18]",
"For suspected hematoma, reconcile anticoagulant exposure, platelet count, renal function, and neuraxial procedure history while arranging emergent imaging and specialist intervention.[18]",
"For degenerative cervical myelopathy, gait impairment, upper motor neuron findings, and hand dysfunction may be more informative than pain severity; abrupt deterioration warrants urgent imaging and spine assessment.[18]"
],
"subsections": [],
"table": {
"caption": "Immediate management differs by nonmalignant cause.[18][21]",
"columns": [
"Cause",
"Immediate management emphasis",
"Definitive intervention"
],
"rows": [
[
"Epidural abscess",
"Cultures, IV antimicrobials, urgent MRI, and neurosurgical/spine consultation",
"Decompression and drainage when neurologic compromise, instability, or medical failure is present.[18]"
],
[
"Epidural hematoma",
"Urgent MRI and assessment of anticoagulant-related bleeding risk",
"Prompt evacuation for severe or progressive deficit.[18]"
],
[
"Traumatic compression",
"Resuscitation, spinal motion restriction, CT, and MRI when clinically indicated",
"Reduction, decompression, and stabilization according to injury morphology and neurologic status.[15][21]"
],
[
"Degenerative myelopathy",
"MRI to establish cord compression and operative anatomy",
"Decompression for moderate-to-severe disease or abrupt worsening; conservative care may be appropriate in selected mild disease.[18]"
]
]
}
},
{
"id": "monitoring-and-communication",
"eyebrow": "After diagnosis",
"heading": "Monitor function, instability, and treatment complications",
"intro": "Serial examination is the clinically meaningful measure of whether treatment is succeeding.",
"paragraphs": [
"Repeat motor, sensory, gait, and sphincter assessments at clinically appropriate intervals during acute evaluation and after intervention. Escalating pain, new weakness, declining ambulation, or new bladder/bowel dysfunction should trigger reassessment for progression, instability, treatment failure, recurrent compression, infection, or hematoma.[18][23]",
"In MSCC, formal assessment of spinal stability and prognosis can improve communication and documentation. The Spinal Instability Neoplastic Score (SINS) may be useful as an adjunct, particularly to help rule out instability at lower scores, but evidence is limited and it should not replace expert clinical and radiologic assessment.[22][23]",
"Communicate prognosis without presenting a score as determinative. Baseline ambulation, tumor biology, visceral disease, performance status, neurologic deficit, and response options influence outcomes; patient goals may reasonably favor surgery, radiotherapy, symptom-focused care, or a combination.[17][23]"
],
"bullets": [
"After corticosteroid initiation: monitor glucose, mental status, gastrointestinal toxicity, infection risk, and need for taper after definitive treatment.[18][23]",
"After surgery: monitor neurologic examination, wound complications, instrumentation/stability concerns, venous thromboembolism risk, pain, and rehabilitation needs.[17]",
"Begin discharge and rehabilitation planning early; mobility aids, bladder/bowel care, pressure-injury prevention, caregiver training, and coordinated community services are core components of preserving independence.[23]"
],
"subsections": [],
"table": null
}
],
"faq": [
{
"question": "What is the preferred imaging test for suspected malignant spinal cord compression?",
"answer": "Whole-spine gadolinium-enhanced MRI is preferred because it defines epidural disease, cord or cauda equina compression, and noncontiguous lesions. CT myelography is reserved for MRI contraindication or unavailability.[9][18]"
},
{
"question": "When should dexamethasone be started in malignant spinal cord compression?",
"answer": "Start promptly when MSCC causes neurologic signs or symptoms while arranging definitive therapy. Standard-dose approaches are favored over high-dose regimens because high-dose dexamethasone increases serious toxicity without clear additional neurologic benefit.[18][23]"
},
{
"question": "Which patients with metastatic spinal cord compression should be considered for surgery?",
"answer": "Consider decompression and stabilization for instability, bony retropulsion, radioresistant tumor, progressive neurologic deficit, need for tissue diagnosis, or recurrence after radiotherapy in a patient with sufficient fitness and expected benefit.[17][23]"
},
{
"question": "Can absence of fever exclude spinal epidural abscess?",
"answer": "No. Fever may be absent, and the classic triad of fever, back pain, and neurologic deficit is often incomplete. Risk factors plus focal pain or neurologic symptoms warrant urgent contrast-enhanced MRI.[18]"
},
{
"question": "Should SINS or another prognostic score determine treatment alone?",
"answer": "No. SINS and prognostic scores can standardize assessment and communication, but evidence is limited and treatment decisions require integrated assessment of neurologic status, stability, tumor biology, systemic prognosis, and patient preferences.[22][23]"
}
],
"references": [
{
"number": 1,
"title": "Reference ID: 5578772 - accessdata.fda.gov",
"detail": "www.accessdata.fda.gov",
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"host": "www.accessdata.fda.gov"
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"number": 2,
"title": "highlights of prescribing information",
"detail": "dailymed.nlm.nih.gov",
"url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a887020f-b41f-49fe-8379-f01147b2a796&type=display",
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"title": "VYBRIQUETM (sildenafil) oral film - accessdata.fda.gov",
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"url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/210858s000lbl.pdf",
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"number": 5,
"title": "These highlights do not include all the information needed to use PREGABALIN CAPSULES safely and effectively. See full prescribing information for PREGABALIN CAPSULES.
\n
PREGABALIN capsules, for oral use, CV
Initial U.S. Approval: 2004",
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"number": 12,
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"number": 13,
"title": "Spinal cord compression Outcome of early detection and ...",
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"title": "https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/ ...",
"detail": "nctr-crs.fda.gov",
"url": "https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/bfdfe235-d717-4855-a3c8-a13d26dadede/spl-doc",
"authors": "nctr-crs.fda.gov",
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"snippet": "See full prescribing information for OXYCONTIN. treatment initiation and dose adjustment. tricyclic antidepressants (TCAs), certain muscle relaxants",
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"number": 5,
"title": "These highlights do not include all the information needed to use PREGABALIN CAPSULES safely and effectively. See full prescribing information for PREGABALIN CAPSULES.
\n
PREGABALIN capsules, for oral use, CV
Initial U.S. Approval: 2004",
"detail": "www.accessdata.fda.gov",
"url": "https://www.accessdata.fda.gov/spl/data/d9a1cb89-c0ba-4049-bf7a-17bfe759f286/d9a1cb89-c0ba-4049-bf7a-17bfe759f286.xml",
"authors": "www.accessdata.fda.gov",
"host": "www.accessdata.fda.gov",
"snippet": "| | | |\n --- \n| INDICATION | Dosing Regimen | Maximum Dose |\n| DPN Pain (2.2) | 3 divided doses per day | 300 mg/day within 1 week |\n| PHN (2.3) | 2 or 3 divided doses per day | 300 mg/day within 1 week. Maximum dose of 600 mg/day. |\n| Adjunctive Therapy for Partial-Onset Seizures in Adult Pat",
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"number": 6,
"title": "DailyMed - JULUCA- dolutegravir sodium and rilpivirine hydrochloride tablet, film coated",
"detail": "dailymed.nlm.nih.gov",
"url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=806653d1-bf35-4924-b999-ad5d21821cc1",
"authors": "dailymed.nlm.nih.gov",
"host": "dailymed.nlm.nih.gov",
"snippet": "## 8.6 Renal Impairment\n\nNo dosage adjustment is necessary for patients with mild or moderate renal impairment (creatinine clearance greater than or equal to 30 mL/min) see Clinical Pharmacology ([12.3)]. In patients with severe renal impairment (creatinine clearance less than 30 mL/min) or end-stag",
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"number": 7,
"title": "These highlights do not include all the information needed to use DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE TABLETS safely and effectively. See full prescribing information for DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE TABLETS.\n \n \nDILTIAZEM HYDROCHLORIDE extended-release tablets, for oral use\n \nInitial U.S. Approval: 1982",
"detail": "dailymed.nlm.nih.gov",
"url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f7137458-0db3-7ecd-e053-6394a90a5f95&type=display",
"authors": "dailymed.nlm.nih.gov",
"host": "dailymed.nlm.nih.gov",
"snippet": "## 8.5 Geriatric Use\n\nClinical studies of diltiazem did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger pati",
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{
"number": 8,
"title": "[PDF] 022462Orig1s000 - accessdata.fda.gov",
"detail": "www.accessdata.fda.gov",
"url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022462Orig1s000MedR.pdf",
"authors": "www.accessdata.fda.gov",
"host": "www.accessdata.fda.gov",
"snippet": "associated with intrathecal drug infusion catheters: report and observations on 41 patients. Neurosurgery. 2002;50:78-87. 15 Cabbell, KL, Taren JA, Sagher O. Spinal cord compression by catheter granulomas in high-dose intrathecal morphine therapy: case report. Neurosurgery. 1998;42:1176-1181. 16 Sch",
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{
"number": 9,
"title": "Malignant spinal cord compression - Symptoms, diagnosis and treatment | BMJ Best Practice",
"detail": "bestpractice.bmj.com",
"url": "https://bestpractice.bmj.com/topics/en-us/3000286",
"authors": "bestpractice.bmj.com",
"host": "bestpractice.bmj.com",
"snippet": "Prognosis is more favourable for previously ambulatory patients and for patients who have been immobile for less than 24 hours.\n\n### Definition [...] open menu\n\nWhen viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflect",
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{
"number": 10,
"title": "Spinal Cord Compression - an overview",
"detail": "www.sciencedirect.com",
"url": "https://www.sciencedirect.com/topics/neuroscience/spinal-cord-compression",
"authors": "www.sciencedirect.com",
"host": "www.sciencedirect.com",
"snippet": "Many variables influence the functional outcome of ESCC with the pre-treatment neurologic status being the most important determinant of functional prognosis [16–18]. Bowel and bladder dysfunction is an unfavorable prognostic sign and the extent of subarachnoid block is related to degree of motor a",
"score": 0.6615081
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{
"number": 11,
"title": "Metastatic Epidural Spinal Cord Compression - an overview",
"detail": "www.sciencedirect.com",
"url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/metastatic-epidural-spinal-cord-compression",
"authors": "www.sciencedirect.com",
"host": "www.sciencedirect.com",
"snippet": "Surgery is not always indicated in the treatment of MESCC. This is especially true in patients with a poor oncologic prognosis. Rades and colleagues developed a scoring system to evaluate which patients should not be operated. In order to build their 25-point score, the authors considered the main p",
"score": 0.53342235
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"number": 12,
"title": "Comprehensive guide to the diagnosis, management, and treatment of metastatic spinal cord compression syndrome",
"detail": "www.sciencedirect.com",
"url": "https://www.sciencedirect.com/science/article/pii/S0960740425001562",
"authors": "www.sciencedirect.com",
"host": "www.sciencedirect.com",
"snippet": "1. Highlights\n2. Abstract\n3. Keywords\n4. 1. Introduction\n5. 2. Materials and methods\n6. 3. Results\n7. 4. Pathophysiology\n8. 5. Clinical presentation\n9. 6. Diagnosis\n10. 7. Prognostic evaluation\n11. 8. Stability evaluation\n12. 9. Compression degree evaluation\n13. 10. Holisti",
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"number": 13,
"title": "Spinal cord compression Outcome of early detection and ...",
"detail": "www.sciencedirect.com",
"url": "https://www.sciencedirect.com/science/article/abs/pii/S0167814007005531",
"authors": "www.sciencedirect.com",
"host": "www.sciencedirect.com",
"snippet": "by R Venkitaraman · 2007 · Cited by 24 — The median neurologic deficit free interval was 804 days for the patients who had rSCC and 989 days for those who had no rSCC on MRI. rSCC on MRI did not",
"score": 0.28888544
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"number": 14,
"title": "A Clinical Practice Guideline for the Management of Patients ...",
"detail": "pmc.ncbi.nlm.nih.gov",
"url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5684845",
"authors": "pmc.ncbi.nlm.nih.gov",
"host": "pmc.ncbi.nlm.nih.gov",
"snippet": "The review by Bozzo et al briefly mentioned that ongoing spinal cord compression is a feature that may alter management.2 The rationale for this is based on the concept that spinal cord compression causes tissue ischemia, resulting in damage and cell loss in the spinal cord. Selden et al stated that",
"score": 0.69399214
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{
"number": 15,
"title": "A Clinical Practice Guideline for the Management of Acute Spinal Cord Injury: Introduction, Rationale, and Scope",
"detail": "pmc.ncbi.nlm.nih.gov",
"url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5684846",
"authors": "pmc.ncbi.nlm.nih.gov",
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"snippet": "The first section of this guideline aims to define the optimal timing of surgical decompression by comparing outcomes and safety between patients decompressed early (≤24 hours of injury) versus late (>24 hours of injury). Preclinical evidence has suggested that persistent compression of the spinal c",
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"number": 16,
"title": "The Management of Metastatic Spinal Cord Compression in ...",
"detail": "pmc.ncbi.nlm.nih.gov",
"url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10216687",
"authors": "pmc.ncbi.nlm.nih.gov",
"host": "pmc.ncbi.nlm.nih.gov",
"snippet": "NICE DG75 clinical guideline for assessment of MSCC (“NICE guideline”) [6,12] (use of MRI, use of full spine MRI to assess MSCC, neurologic examination, assessment by all treating clinicians, and clinical assessment of pain, sphincter control, and limb strength and sensitivity). [...] ### 3.4. Agree",
"score": 0.6279746
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"number": 17,
"title": "Treatment of metastatic spinal cord compression: cepo review ...",
"detail": "pmc.ncbi.nlm.nih.gov",
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"authors": "pmc.ncbi.nlm.nih.gov",
"host": "pmc.ncbi.nlm.nih.gov",
"snippet": "The cepo thanks Ghassan Boubez md, Hôpital Notre-Dame (chum); Carolyn Freeman md, Montreal General Hospital (muhc); Alain Jodoin md, Hôpital du Sacré-Cœur de Montréal; Mélanie Gionet md, Hôpital régional de Rimouski (csss de Rimouski–Neigette); Jean-Marc Lépine md, Hôtel-Dieu de Québec (chu de Québe",
"score": 0.588062
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{
"number": 18,
"title": "Spinal Cord Compression - StatPearls - NCBI Bookshelf",
"detail": "www.ncbi.nlm.nih.gov",
"url": "https://www.ncbi.nlm.nih.gov/books/NBK557604",
"authors": "www.ncbi.nlm.nih.gov",
"host": "www.ncbi.nlm.nih.gov",
"snippet": "This activity reviews the evaluation and management of atraumatic spinal cord compression. It highlights the roles of the emergency physician, neurosurgeon, and inpatient care team in treating patients with this condition. Atraumatic spinal cord compression occurs as a result of numerous possible et",
"score": 0.55998856
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"number": 19,
"title": "Emergency treatment of malignant extradural spinal cord compression: an evidence-based guideline - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews - NCBI Bookshelf",
"detail": "www.ncbi.nlm.nih.gov",
"url": "https://www.ncbi.nlm.nih.gov/books/NBK67242",
"authors": "www.ncbi.nlm.nih.gov",
"host": "www.ncbi.nlm.nih.gov",
"snippet": "## Indexing Status\n\nSubject indexing assigned by NLM\n\n## MeSH\n\nAnti-Inflammatory Agents /therapeutic use; Dexamethasone /therapeutic use; Emergencies; Evidence-Based Medicine; Humans; Practice Guidelines as Topic; Spinal Cord Compression /etiology /radiotherapy /surgery /therapy; Spinal Cord Neoplas",
"score": 0.50022036
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{
"number": 20,
"title": "Metastatic Spinal Cord Compression - NCBI Bookshelf",
"detail": "www.ncbi.nlm.nih.gov",
"url": "https://www.ncbi.nlm.nih.gov/books/NBK55007",
"authors": "www.ncbi.nlm.nih.gov",
"host": "www.ncbi.nlm.nih.gov",
"snippet": "Warning:\nThe NCBI web site requires JavaScript to function.\nmore...\n\nU.S. flag\n\nAn official website of the United States government\n\nDot gov\n\nThe .gov means it's official.\n \nFederal government websites often end in .gov or .mil. Before\nsharing sensitive information, make sure you're on a federal\ngo",
"score": 0.4560954
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{
"number": 21,
"title": "Spinal Cord Injuries - StatPearls - NCBI Bookshelf",
"detail": "www.ncbi.nlm.nih.gov",
"url": "https://www.ncbi.nlm.nih.gov/books/NBK560721",
"authors": "www.ncbi.nlm.nih.gov",
"host": "www.ncbi.nlm.nih.gov",
"snippet": "Social workers and case managers facilitate care transitions, arrange community resources, and assist with insurance and reimbursement processes. Psychiatrists or psychologists address the significant mental health challenges commonly encountered by patients, including depression, anxiety, and emoti",
"score": 0.19557908
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{
"number": 22,
"title": "Spinal metastases and metastatic spinal cord compression",
"detail": "www.nice.org.uk",
"url": "https://www.nice.org.uk/guidance/ng234/evidence/k-prognostic-tools-spinal-instability-pdf-472849134229",
"authors": "www.nice.org.uk",
"host": "www.nice.org.uk",
"snippet": "were made for this review question. 55 FINAL Prognostic tools – spinal instability Spinal metastases and metastatic spinal cord compression: evidence reviews for Prognostic tools – spinal instability FINAL (September 2023) Appendix L Study data (thresholds and true positive, false positive, false ne",
"score": 0.67885995
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{
"number": 23,
"title": "Rationale and impact | Spinal metastases and metastatic spinal cord compression | Guidance | NICE",
"detail": "www.nice.org.uk",
"url": "https://www.nice.org.uk/guidance/NG234/chapter/rationale-and-impact",
"authors": "www.nice.org.uk",
"host": "www.nice.org.uk",
"snippet": "There was a large amount of evidence for many different prognostic scoring systems, including original and revised versions for some. Analysis showed that these varied in their ability to predict survival, and none of the systems reviewed were better overall at predicting prognosis. The committee no",
"score": 0.45333505
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{
"number": 24,
"title": "NATIONAL INSTITUTE FOR HEALTH AND CARE ...",
"detail": "www.nice.org.uk",
"url": "https://www.nice.org.uk/guidance/qs56/documents/metastatic-spinal-cord-compression-briefing-paper2",
"authors": "www.nice.org.uk",
"host": "www.nice.org.uk",
"snippet": "cord compression will increase in the future with improving cancer treatments resulting in better survival rates and outcomes. The median age at the time of metastatic spinal cord compression diagnosis is 65 years. Audit data suggests that 77% of patients diagnosed with metastatic spinal cord compre",
"score": 0.33941197
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],
"publishedAt": "2026-08-20T23:58:37.232291Z",
"updatedAt": "2026-08-20T23:58:37.232291Z",
"readingMinutes": 6,
"slug": "spinal-cord-compression"
}