{ "schemaVersion": 2, "eyebrow": "Perioperative Medicine", "title": "Postoperative Delirium", "summary": "Postoperative delirium requires structured bedside detection, rapid identification of reversible physiologic and medication precipitants, safety-focused nonpharmacologic management, and selective escalation for severe agitation. Prevention begins before surgery by identifying cognitive vulnerability and implementing multicomponent perioperative care.", "seoDescription": "Point-of-care guidance for recognizing, preventing, evaluating, and managing postoperative delirium in older surgical patients.", "clinicalQuestion": "How should physicians prevent, detect, evaluate, and manage postoperative delirium while avoiding ineffective routine pharmacotherapy?", "specialty": "Perioperative Medicine", "audience": "U.S. physicians and medical trainees", "tags": [ "postoperative delirium", "perioperative geriatrics", "CAM-ICU", "delirium prevention", "dexmedetomidine", "older surgical patients" ], "keyTakeaways": [ "Use a validated bedside instrument, such as CAM or CAM-ICU, rather than clinical impression alone; hypoactive delirium is commonly missed. [5][15][22]", "Treat new postoperative delirium as an acute medical change: first identify hypoxemia, hemodynamic instability, infection, metabolic abnormalities, uncontrolled pain, medication toxicity or withdrawal, and urinary or bowel retention. [22][23]", "Routine antipsychotics are not supported for prevention or treatment of delirium and should not substitute for cause-directed management and nonpharmacologic measures. [2][3][21]", "For older surgical patients, prioritize multicomponent prevention: medication review, orientation, sensory support, sleep protection, adequate fluids and nutrition, pain control, and early mobility. [19][23][24]", "Dexmedetomidine has shown preventive benefit in some postoperative populations, but ICU guidance does not support routine pharmacologic prophylaxis; selection must account for setting and hemodynamic tolerance. [1][7][21]" ], "sections": [ { "id": "recognition-and-triage", "eyebrow": "First postoperative change", "heading": "Recognize delirium and exclude immediately dangerous mimics", "intro": "A fluctuating postoperative mental-status change requires formal assessment and physiologic triage.", "paragraphs": [ "Screen with a validated tool such as the Confusion Assessment Method (CAM) or CAM-ICU; both operationalize delirium detection in hospitalized and postoperative populations. [5][10][14][15] Assess at least twice daily during the early postoperative period in patients at elevated risk, because delirium fluctuates and a single normal examination does not exclude it. [14][24]", "At recognition, obtain vital signs, oxygenation assessment, bedside glucose, focused neurologic examination, medication administration history, pain assessment, intake-output review, and examination for urinary retention or constipation. Escalate immediately for focal neurologic findings, depressed consciousness, severe hypoxemia, shock, or other evidence of acute organ dysfunction; delirium may reflect systemic illness, metabolic disturbance, pharmacologic effects, trauma, or iatrogenic/environmental precipitants. [22][24]", "Do not label all postoperative agitation as delirium. Establish whether the course is acute and fluctuating with impaired attention; compare with the preoperative cognitive baseline through family, caregivers, or prior records. Preexisting dementia and functional, visual, hearing, or frailty-related impairment increase vulnerability, but do not explain an abrupt change without evaluating a superimposed precipitant. [22]" ], "bullets": [ "Prioritize a reversible physiologic trigger when delirium begins abruptly after a change in respiratory status, hemodynamics, analgesic or sedative exposure, or new systemic illness. [22][23]", "Document delirium phenotype, including hypoactive, hyperactive, or mixed behavior, because hypoactive presentations are frequently under-recognized. [22]" ], "subsections": [], "table": { "caption": "Bedside branching for acute postoperative cognitive change. [14][22][24]", "columns": [ "Finding", "Interpretation", "Immediate next action" ], "rows": [ [ "Acute, fluctuating inattention on CAM or CAM-ICU", "Postoperative delirium is likely. [10][14][15]", "Search for precipitants; begin a multicomponent safety and orientation plan. [23][24]" ], [ "Focal neurologic deficit or markedly reduced consciousness", "Consider a neurologic or other life-threatening cause rather than uncomplicated delirium. [22]", "Urgently escalate diagnostic evaluation and stabilization. [22]" ], [ "Hypoxemia, hypotension, fever, metabolic abnormality, or marked pain", "Potential active precipitant. [22][23]", "Correct the identified physiologic abnormality and reassess cognition. [22]" ], [ "Recent sedative, psychoactive, anticholinergic, or medication-withdrawal exposure", "Medication-associated or withdrawal-associated delirium is possible. [20][22][23]", "Reconcile medications; stop nonessential precipitating agents and avoid abrupt cessation of chronic benzodiazepines. [23]" ] ] } }, { "id": "risk-stratification-and-prevention", "eyebrow": "Before and after surgery", "heading": "Identify high-risk patients and deploy multicomponent prevention", "intro": "Risk identification should trigger a care bundle, not routine prophylactic medication.", "paragraphs": [ "Patients older than 60 years have reported postoperative delirium incidence of approximately 10% to 20%, while incidence varies substantially across surgical populations and ascertainment methods. [1][9][22][24] Preoperative cognitive impairment or dementia, functional impairment, sensory impairment, frailty, chronic neurologic, cardiovascular, or psychiatric disease, and advanced age identify patients who should receive intensified preventive measures. [22]", "Use preoperative cognitive assessment and medication reconciliation to establish baseline and reduce avoidable exposure to medications that can precipitate delirium. Benzodiazepines can themselves precipitate delirium, but chronic benzodiazepines should not be abruptly discontinued preoperatively because discontinuation has also been associated with increased postoperative delirium risk. [20][23]", "Implement a multicomponent postoperative bundle: frequent orientation and cognitive stimulation, access to glasses and hearing aids, family presence when feasible, sleep protection, fluid and nutrition management, adequate analgesia, early mobilization, and daily delirium screening. These measures target modifiable environmental, sensory, immobility, sleep, and physiologic contributors. [19][23][24]" ], "bullets": [ "Flag patients with baseline cognitive impairment or frailty for proactive caregiver engagement and standardized CAM or CAM-ICU surveillance. [10][22][23]", "Treat pain while minimizing unnecessary sedative-hypnotic exposure; uncontrolled pain and psychoactive medication exposure are both relevant postoperative precipitants. [22][23]", "Use early mobility when medically feasible; early mobilization is included in contemporary multicomponent postoperative strategies. [23]" ], "subsections": [ { "heading": "Interpreting neuroimaging vulnerability", "paragraphs": [ "Preoperative cerebral small-vessel disease markers on MRI identify a population with greater postoperative delirium risk but do not establish an acute cause of delirium. In adults aged 65 to 85 years undergoing elective noncardiac surgery, lacunes and white-matter hyperintensities were associated with delirium, and the most severe small-vessel disease burden corresponded to a 28% delirium risk. [14]" ], "bullets": [ "Use known lacunes or extensive white-matter disease to intensify prevention and monitoring; do not obtain MRI solely to diagnose routine postoperative delirium on the basis of this association. [14]" ] } ], "table": { "caption": "Prevention decisions for postoperative delirium. [1][19][21][23][24]", "columns": [ "Intervention", "Role", "Key limitation or selection issue" ], "rows": [ [ "Multicomponent nonpharmacologic bundle", "Core prevention for high-risk postoperative patients. [19][23][24]", "Requires reliable implementation across nursing, surgical, anesthesia, rehabilitation, and family supports. [19][23]" ], [ "Medication reconciliation and avoidance of nonessential psychoactive agents", "Reduces modifiable pharmacologic exposure. [20][23][24]", "Avoid abrupt preoperative cessation of chronic benzodiazepines. [23]" ], [ "Dexmedetomidine", "May reduce postoperative delirium in selected surgical populations. [1][7]", "Do not treat as universal prophylaxis; ICU guidance suggests against routine dexmedetomidine prophylaxis. [21]" ], [ "Haloperidol or atypical antipsychotic prophylaxis", "Not routine prophylaxis. [2][3][21]", "Evidence does not support routine use and adverse effects require consideration. [16][21]" ] ] } }, { "id": "etiologic-workup", "eyebrow": "Cause-directed evaluation", "heading": "Use the postoperative context to target the diagnostic workup", "intro": "Testing should follow the timing, examination, medication record, and physiologic abnormalities.", "paragraphs": [ "Build the differential around common precipitant domains: surgical stress and complications, systemic illness or organ dysfunction, metabolic abnormalities, pharmacologic effects, iatrogenic or environmental factors, trauma, and withdrawal states. [22] Correct identified metabolic abnormalities promptly and reassess after each intervention rather than assuming persistent confusion is primary neurologic disease. [22]", "Review the anesthetic, perioperative medication administration record, and home medications for sedative-hypnotics, anxiolytics, anticonvulsants, muscle relaxants, anticholinergic drugs, opioids, and dopaminergic agents. Medication burden can precipitate delirium; conversely, benzodiazepine withdrawal is a clinically important exception when chronic therapy has been interrupted. [4][16][23]", "Match tests to clinical evidence of a precipitant. Evaluate respiratory compromise when oxygenation or ventilation is abnormal; investigate infection or organ dysfunction when fever, hemodynamic change, localizing symptoms, or laboratory abnormalities are present; and assess urinary or bowel retention when examination or output history suggests obstruction. For new focal deficits or atypical depressed consciousness, urgently evaluate for structural neurologic disease. [22]" ], "bullets": [ "Reassess pain, sedation level, oxygenation, blood pressure, and medication exposures after each corrective action; persistent delirium may reflect more than one precipitant. [22][23]", "Avoid broad, low-yield testing without a symptom, examination, or physiologic trigger; delirium evaluation should be driven by suspected systemic, metabolic, pharmacologic, or neurologic causes. [5][22]" ], "subsections": [], "table": { "caption": "Etiologic patterns that change postoperative delirium management. [22][23]", "columns": [ "Pattern", "Clinical clue", "Cause-directed action" ], "rows": [ [ "Respiratory or circulatory dysfunction", "Abnormal oxygenation, ventilation, blood pressure, or perfusion. [22]", "Stabilize physiologic derangement and reassess cognition. [22]" ], [ "Medication toxicity or polypharmacy", "Temporal relation to sedative, psychoactive, anticholinergic, opioid, or other implicated drug exposure. [4][16][22]", "Stop or reduce nonessential precipitating drugs; review cumulative perioperative exposures. [20][23]" ], [ "Benzodiazepine withdrawal", "Chronic benzodiazepine use interrupted perioperatively. [23]", "Avoid abrupt discontinuation; manage as a withdrawal-associated state rather than using benzodiazepines routinely for delirium. [23]" ], [ "Metabolic or systemic illness", "Laboratory abnormalities, fever, organ dysfunction, or new clinical deterioration. [22]", "Correct abnormality and treat the identified systemic process. [22]" ], [ "Environmental and functional precipitants", "Sleep disruption, sensory deprivation, immobilization, disorientation, or inadequate intake. [19][23][24]", "Implement orientation, sensory aids, sleep protection, mobility, fluids, and nutrition. [19][23][24]" ] ] } }, { "id": "management", "eyebrow": "Established delirium", "heading": "Manage safety, reversible causes, and distress without routine antipsychotics", "intro": "The primary treatment is removal or correction of the precipitating insult plus a structured nonpharmacologic plan.", "paragraphs": [ "Immediately protect the patient and staff while preserving assessment capacity. Use verbal de-escalation, reorientation, familiar environmental cues, sensory aids, family involvement, and mobilization when safe. Family presence supports behavioral management and reorientation, while multicomponent interventions can reduce symptom severity and duration. [22][23]", "Treat the documented driver: correct metabolic abnormalities, address hypoxemia or hemodynamic instability, optimize analgesia, manage retention, treat confirmed systemic illness, and discontinue nonessential precipitating medications. [22][23] Continue regular CAM or CAM-ICU assessment to document fluctuation and response to cause-directed treatment. [10][14][15]", "Do not prescribe haloperidol or an atypical antipsychotic routinely to prevent or resolve delirium. Systematic-review and ICU guideline summaries do not support routine antipsychotic use for prevention or treatment, and pharmacologic treatment has not consistently improved outcomes. [2][3][17][21] For hyperactive delirium, pharmacologic therapy may be considered only when verbal de-escalation fails, so medication use is reserved for immediate behavioral risk rather than delirium resolution. [22]", "Do not use benzodiazepines routinely to prevent or treat postoperative delirium in older or critically ill adults. Their relevant exception is withdrawal-associated delirium or prevention of withdrawal in a chronically exposed patient, where abrupt discontinuation can worsen risk. [23]" ], "bullets": [ "Use nonpharmacologic measures concurrently with correction of physiologic and medication precipitants; neither approach is adequate alone when an active driver remains. [22][23]", "For severe agitation, document the immediate safety indication, attempted de-escalation, and serial reassessment; avoid continuing pharmacologic restraint once the behavioral emergency resolves. [22]", "Continue delirium surveillance after apparent improvement because postoperative symptoms fluctuate. [14][24]" ], "subsections": [ { "heading": "ICU and postoperative sedation decisions", "paragraphs": [ "In critically ill adults, current guideline summaries suggest against routine dexmedetomidine, statins, or ketamine solely to prevent delirium. [21] This differs from evidence that dexmedetomidine may reduce postoperative delirium in selected surgical populations; therefore, use should be individualized to the anesthetic or ICU sedation plan rather than initiated as a universal delirium treatment. [1][7][21]" ], "bullets": [ "Do not substitute a sedative strategy for treatment of hypoxemia, infection, metabolic derangement, pain, or withdrawal. [22][23]" ] } ], "table": { "caption": "Management priorities after a positive delirium screen. [2][21][22][23]", "columns": [ "Priority", "Action", "Avoid" ], "rows": [ [ "Safety and assessment", "De-escalate, reorient, involve family, restore sensory aids, and assess for immediate physiologic danger. [22][23]", "Assuming agitation alone establishes the diagnosis or cause. [22]" ], [ "Cause-directed treatment", "Correct metabolic abnormalities and address active systemic, respiratory, hemodynamic, pain, retention, or medication-related triggers. [22][23]", "Treating delirium as a stand-alone psychiatric condition. [22]" ], [ "Medication restraint", "Reserve pharmacologic intervention for hyperactive delirium when verbal de-escalation fails. [22]", "Routine antipsychotics for prevention or treatment. [2][3][21]" ], [ "Withdrawal prevention", "Maintain or carefully manage chronic benzodiazepine exposure when withdrawal is a concern. [23]", "Abrupt benzodiazepine discontinuation. [23]" ] ] } }, { "id": "monitoring-and-prognosis", "eyebrow": "Disposition and follow-up", "heading": "Monitor resolution, function, and postdischarge risk", "intro": "A positive delirium screen identifies a patient at higher short-term clinical risk and functional vulnerability.", "paragraphs": [ "Track delirium status serially with the same validated instrument, alongside oxygenation, hemodynamics, pain, medication changes, bowel and bladder function, hydration, nutrition, mobility, and sleep. [14][19][23] Escalate or reopen the diagnostic evaluation when delirium persists despite correction of the suspected precipitant, when new focal findings develop, or when physiologic instability emerges. [22]", "Postoperative delirium is associated with adverse longer-term outcomes. In adults older than 60 years, reported 30-day mortality was 7% to 10% among patients with postoperative delirium versus 1% among those without delirium; these observational data support explicit discharge communication and follow-up planning rather than assuming cognition will normalize at discharge. [22]", "Before discharge, communicate the delirium episode, baseline cognition, suspected precipitants, medication changes, residual cognitive or functional deficits, and needed caregiver supervision. Because delirium is associated with institutionalization, morbidity, prolonged hospitalization, and mortality, disposition should account for the patient's ability to mobilize, maintain intake, and safely manage medications after surgery. [24]" ], "bullets": [ "Include delirium status and residual cognitive deficits in handoff to rehabilitation, skilled nursing, primary care, and caregivers. [22][24]", "If the patient has persistent fluctuating attention or altered arousal, do not rely on a single reassuring encounter to determine cognitive recovery. [14][24]" ], "subsections": [], "table": { "caption": "Monitoring elements that guide escalation and disposition. [14][22][23][24]", "columns": [ "Domain", "What to document", "Why it changes care" ], "rows": [ [ "Delirium trajectory", "Serial CAM or CAM-ICU results and phenotype. [10][14][15]", "Fluctuation may reveal persistent or recurrent delirium. [14][24]" ], [ "Precipitant response", "Correction of oxygenation, hemodynamics, metabolic abnormalities, pain, retention, and medication exposures. [22][23]", "Failure to improve requires renewed etiologic assessment. [22]" ], [ "Functional recovery", "Mobility, intake, sensory access, and caregiver support. [19][23][24]", "Determines feasibility of safe discharge and need for postacute support. [24]" ], [ "Transition communication", "Baseline cognition, episode details, medication changes, and residual deficits. [22][24]", "Supports continued surveillance after a high-risk postoperative event. [22][24]" ] ] } } ], "faq": [], "references": [ { "number": 1, "title": "Postoperative Delirium Prevention in Older Adults | NEJM Clinician", "detail": "clinician.nejm.org", "url": "https://clinician.nejm.org/postoperative-delirium-prevention-older-adults-CLINjwNA59852", "authors": "clinician.nejm.org", "host": "clinician.nejm.org" }, { "number": 2, "title": "Evaluation of delirium - Differential diagnosis of symptoms | BMJ Best Practice US", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-us/241", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com" }, { "number": 3, "title": "Assessment of delirium - Differential diagnosis of symptoms | BMJ Best Practice", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-gb/241", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com" }, { "number": 4, "title": "Delirium in elderly adults: diagnosis, prevention and treatment | Nature Reviews Neurology", "detail": "www.nature.com", "url": "https://www.nature.com/articles/nrneurol.2009.24", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 5, "title": "Delirium | Annals of Internal Medicine", "detail": "www.acpjournals.org", "url": "https://www.acpjournals.org/doi/abs/10.7326/AITC202010060", "authors": "www.acpjournals.org", "host": "www.acpjournals.org" }, { "number": 6, "title": "The effect of perioperative anesthetics for prevention of ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0952818019304246", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 7, "title": "Trials Focusing on Prevention and Treatment of Delirium After Cardiac Surgery: A systematic Review of Randomized Evidence - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S1053077019309899", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 8, "title": "Effectiveness of dipyrone (metamizole) in postoperative analgesia: A systematic review and meta-analysis", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S2210844025000243", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 9, "title": "Artificial Intelligence‐Based Delirium Prediction Model for ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/10.1111/jan.70456?af=R", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com" }, { "number": 10, "title": "Preoperative cognitive function as a risk factor of ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jso.27730", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com" }, { "number": 11, "title": "Postoperative Delirium in the Oldest–Old: Parallel ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.71332", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com" }, { "number": 12, "title": "Prognostic Factors for Postoperative Complications. 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Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "Postoperative Delirium Prevention in Older Adults | NEJM Clinician", "detail": "clinician.nejm.org", "url": "https://clinician.nejm.org/postoperative-delirium-prevention-older-adults-CLINjwNA59852", "authors": "clinician.nejm.org", "host": "clinician.nejm.org", "snippet": "###### Topics\n\n###### Clinical Takeaway\n\n## Context\n\nAn estimated 25% of older surgical patients develop postoperative delirium, which is associated with worse long-term outcomes (see Figure 1). Results of drug studies for prevention of delirium have been mixed, and current guidelines do not recomme", "score": 0.78194773 }, { "number": 2, "title": "Evaluation of delirium - Differential diagnosis of symptoms | BMJ Best Practice US", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-us/241", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com", "snippet": "Dopaminergic excess is also believed to contribute. Evidence does not appear to support the use of antipsychotic drugs (dopamine antagonists) for the prevention or treatment of delirium, but is not entirely consistent.(#referencePop32)Oh ES, Needham DM, Nikooie R, et al. Antipsychotics for preventin", "score": 0.7606688 }, { "number": 3, "title": "Assessment of delirium - Differential diagnosis of symptoms | BMJ Best Practice", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-gb/241", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com", "snippet": "Dopaminergic excess is also believed to contribute. Evidence does not appear to support the use of antipsychotic drugs (dopamine antagonists) for the prevention or treatment of delirium, but is not entirely consistent.(#referencePop32)Oh ES, Needham DM, Nikooie R, et al. Antipsychotics for preventin", "score": 0.7598145 }, { "number": 4, "title": "Delirium in elderly adults: diagnosis, prevention and treatment | Nature Reviews Neurology", "detail": "www.nature.com", "url": "https://www.nature.com/articles/nrneurol.2009.24", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Title: Delirium in elderly adults: diagnosis, prevention and treatment | Nature Reviews Neurology\n# Delirium in elderly adults: diagnosis, prevention and treatment. This article reviews current clinical practice in delirium in elderly individuals, including the diagnosis, treatment, outcomes and eco", "score": 0.8467682 }, { "number": 5, "title": "Delirium | Annals of Internal Medicine", "detail": "www.acpjournals.org", "url": "https://www.acpjournals.org/doi/abs/10.7326/AITC202010060", "authors": "www.acpjournals.org", "host": "www.acpjournals.org", "snippet": "# Delirium. Delirium in hospitalized older adults. **Albrecht JS**, **Marcantonio ER**, **Roffey DM**, **et al**; **Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair Cognitive Ancillary Study Investigators.**. Delirium in mechanically ventilated patients: validit", "score": 0.8235701 }, { "number": 6, "title": "The effect of perioperative anesthetics for prevention of ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0952818019304246", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "* J.A. Hudetz _et al._ ### Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass ### J Cardiothorac Vasc Anesth (2009) * M.F. Folstein _et al._ ### “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician ### J Psychiatr Res (1975", "score": 0.79196626 }, { "number": 7, "title": "Trials Focusing on Prevention and Treatment of Delirium After Cardiac Surgery: A systematic Review of Randomized Evidence - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S1053077019309899", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "# Review Article Trials Focusing on Prevention and Treatment of Delirium After Cardiac Surgery: A systematic Review of Randomized Evidence. ### Aim. This systematic review aimed to gather and summarize the existing evidence from randomized trials concerning interventions studied in the prevention or", "score": 0.7147281 }, { "number": 8, "title": "Effectiveness of dipyrone (metamizole) in postoperative analgesia: A systematic review and meta-analysis", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S2210844025000243", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "For patients undergoing high-risk surgeries, the intensive care unit (ICU) is often the preferred location for postoperative care. Although the most recent Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult ", "score": 0.5582553 }, { "number": 9, "title": "Artificial Intelligence‐Based Delirium Prediction Model for ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/10.1111/jan.70456?af=R", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "We found that the incidence of postoperative delirium ranges from 5.56% to 34%, and commonly used assessment tools include CAM-ICU, DSM-5", "score": 0.6944897 }, { "number": 10, "title": "Preoperative cognitive function as a risk factor of ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jso.27730", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "by HA Varpaei · 2024 · Cited by 18 — Postoperative delirium should be measured and determined by any standardized tools or criteria such as the confusion assessment method (CAM),", "score": 0.63750535 }, { "number": 11, "title": "Postoperative Delirium in the Oldest–Old: Parallel ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.71332", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "At TMUH, delirium assessment was performed using a modified confusion assessment method (CAM) as part of routine clinical care. ... risk", "score": 0.6211049 }, { "number": 12, "title": "Prognostic Factors for Postoperative Complications. An ...", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/full/10.1111/aas.70285", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "by APH Karlsen · 2026 — Postoperative positive delirium in EHR-registered Confusion Assessment Method for the ICU (CAM-ICU) These are validated bedside tools for", "score": 0.6155738 }, { "number": 13, "title": "Dose‐dependent relationship between intra‐operative ...", "detail": "associationofanaesthetists-publications.onlinelibrary.wiley.com", "url": "https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.70163?af=R", "authors": "associationofanaesthetists-publications.onlinelibrary.wiley.com", "host": "associationofanaesthetists-publications.onlinelibrary.wiley.com", "snippet": "... Confusion Assessment Method assessments and diagnostic codes. ... CAM assessments were conducted to detect delirium and those who received", "score": 0.529045 }, { "number": 14, "title": "Cerebral Small-vessel Disease and Postoperative... : Anesthesiology", "detail": "journals.lww.com", "url": "https://journals.lww.com/anesthesiology/fulltext/10.1097/aln.0000000000006189~cerebral-small-vessel-disease-and-postoperative-delirium-in", "authors": "journals.lww.com", "host": "journals.lww.com", "snippet": "## Methods:\n\nThe authors prospectively evaluated patients 65 to 85 yr old who had inpatient elective noncardiac surgery at five academic centers in China. Independent neuroradiologists, masked to clinical data, quantified preoperative magnetic resonance markers of cerebral small-vessel disease, incl", "score": 0.511644 }, { "number": 15, "title": "The incidence and prevalence of delirium across... : Palliative Medicine", "detail": "journals.lww.com", "url": "https://journals.lww.com/00019505-201909000-00002", "authors": "journals.lww.com", "host": "journals.lww.com", "snippet": "Standard consensus criteria such as the International Classification of Diseases (ICD)11 and Diagnostic and Statistical Manual of Mental Disorders (DSM)12 exist to aid physicians in the diagnosis of delirium. There have been multiple editions and updates of these gold standard criteria to reflect di", "score": 0.4920179 }, { "number": 16, "title": "Pharmacologic interventions for prevention of delirium in hospitalized older people: A meta-analysis", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0167494320301655", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "care are all examples of effective interventions. Choices of anesthesia technique may not be associated with a significant difference in the incidence of postoperative delirium in geriatric patients with hip fractures. There are few pharmaceutical measures available for POD treatment. Dexmedetomidin", "score": 0.78413767 }, { "number": 17, "title": "Maintaining comfort, cognitive function, and... : Journal of Trauma ...", "detail": "journals.lww.com", "url": "https://journals.lww.com/jtrauma/fulltext/2014/08000/maintaining_comfort,_cognitive_function,_and.27.aspx?Ppt=Article%7Cjtrauma%3A2014%3A08000%3A00027%7C10.1097%2Fta.0000000000000282%7C", "authors": "journals.lww.com", "host": "journals.lww.com", "snippet": "Delirium. It is important to note that pharmacologic management of delirium has not been consistently shown to improve outcomes. Nonpharmacologic management", "score": 0.5201313 }, { "number": 18, "title": "Dexmedetomidine as a Rapid Bolus for Treatment and... : Anesthesia & Analgesia", "detail": "journals.lww.com", "url": "https://journals.lww.com/anesthesia-analgesia/abstract/2015/11000/dexmedetomidine_as_a_rapid_bolus_for_treatment_and.28.aspx", "authors": "journals.lww.com", "host": "journals.lww.com", "snippet": "Dexmedetomidine as a Rapid Bolus for Treatment and Prophylactic Prevention of Emergence Agitation in Anesthetized Children. In this prospective, double-blind, randomized study, we examined the effect of rapid IV bolus injection of DEX on emergence agitation and the hemodynamic response in a large sa", "score": 0.47606868 }, { "number": 19, "title": "Preventing and treating delirium in clinical settings for older ...", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10493062", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "11. American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. _J Am Geriatr Soc_ 2015; 63: 142–150. doi: 10.1111/jgs.13281 [DOI] [PMC free article] [PubMed] [Goog", "score": 0.79580134 }, { "number": 20, "title": "Evolving Clinical Management of Postoperative Delirium - PMC", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12542918", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "36.Nydahl P, Jeitziner MM, Vater V, Sivarajah S, Howroyd F, McWilliams D, Osterbrink J. Early mobilisation for prevention and treatment of delirium in critically ill patients: systematic review and meta-analysis. _Intensive Crit Care Nurs_. 2023. 74:103334. doi: 10.1016/j.iccn.2022.103334 [DOI] [Pub", "score": 0.78054583 }, { "number": 21, "title": "Prevention and Management of Delirium in the Intensive Care Unit", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7855536", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "incidence or duration of delirium, hospital length of stay, or mortality compared with placebo. The same review did, however, suggest a possibility that atypical antipsychotics may decrease the incidence of delirium specifically in postoperative patients.120 The current SCCM guidelines suggest again", "score": 0.7610953 }, { "number": 22, "title": "Differentiating Delirium Versus Dementia in Older Adults - NCBI", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/books/NBK570594", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Family presence supports behavioral management and reorientation. Effective interprofessional communication and coordination remain essential throughout care. Identified metabolic abnormalities require prompt correction.(#article-131250.r2) For hyperactive delirium, pharmacologic therapy may be cons", "score": 0.7460839 }, { "number": 23, "title": "Recent advances in postoperative delirium in elderly patients", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12920445", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "of postoperative delirium (Tomimaru et al., 2020). Although benzodiazepines are effective for anxiety relief and sedation and can be used in withdrawal-associated delirium, they can paradoxically induce delirium themselves, necessitating careful monitoring during their use (Cui et al., 2020). Notabl", "score": 0.7420672 }, { "number": 24, "title": "Delirium: Screening, Prevention, and Diagnosis – A Systematic Review of the Evidence - NCBI Bookshelf", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/books/NBK82554", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Delirium is a common syndrome in hospitalized or institutionalized adults. It is characterized by the acute onset of altered mental status, hallmarked by difficulty sustaining attention and a fluctuating course. Delirium frequently causes patients, families, and health care providers considerable di", "score": 0.7147281 } ], "publishedAt": "2026-08-24T16:22:14.874356+00:00", "updatedAt": "2026-08-24T16:22:14.874356+00:00", "readingMinutes": 6, "slug": "postoperative-delirium" }