{
  "schemaVersion": 2,
  "eyebrow": "Orthopaedic Trauma",
  "title": "Open Fracture Management",
  "summary": "Open fractures require immediate contamination control, antibiotic prophylaxis, neurovascular assessment, stable skeletal management, and timely definitive soft-tissue coverage. This review prioritizes actions that reduce fracture-related infection, avoid missed vascular or compartment injury, and align debridement, fixation, and reconstruction with injury severity.",
  "seoDescription": "Evidence-based open fracture management: emergency antibiotics, neurovascular assessment, debridement, fixation, soft-tissue coverage, and infection prevention.",
  "clinicalQuestion": "How should clinicians prioritize emergency care, antibiotics, debridement, stabilization, and coverage to minimize infection and preserve limb function after an open fracture?",
  "specialty": "Orthopaedic Trauma",
  "audience": "U.S. physicians and medical trainees",
  "tags": [
    "open fracture",
    "Gustilo-Anderson",
    "open tibia fracture",
    "fracture-related infection",
    "antibiotic prophylaxis",
    "irrigation and debridement",
    "orthoplastic care",
    "external fixation"
  ],
  "keyTakeaways": [
    "Treat any fracture with a concomitant wound as open until proven otherwise; the wound may be distant from the fracture site. [22]",
    "Give intravenous prophylactic antibiotics immediately; prompt delivery is among the most actionable measures to reduce fracture-related infection. [19][20][22]",
    "Do not delay urgent vascular management for angiography when a devascularized limb has persistent hard signs after alignment or reduction. [20]",
    "The historic universal 6-hour debridement rule is unsupported; urgency should reflect contamination, vascular injury, compartment syndrome, patient physiology, and associated injuries. [19][20]",
    "For severe open fractures requiring flap coverage, coordinate definitive fixation and soft-tissue coverage closely; early coverage reduces infection and nonunion risk. [19][20]"
  ],
  "sections": [
    {
      "id": "initial-priorities",
      "eyebrow": "Emergency management",
      "heading": "What to do immediately",
      "intro": "Resuscitation and limb-threatening injury assessment precede definitive fracture decisions.",
      "paragraphs": [
        "Use trauma principles first. Expose the entire injured limb, document motor, sensory, pulse, and perfusion findings before and after any reduction or splinting, and assess for associated injuries. Plain radiographs should include the injured bone and adjacent joints; radiographic soft-tissue gas or foreign bodies support an open injury. CT may define articular involvement in stable patients, and CT angiography can identify vascular injury when pulses are absent. [22]",
        "After gross contamination is addressed only as needed for temporary protection, cover the wound with a saline-soaked sterile dressing and occlusive layer, immobilize in a well-padded splint, and minimize repeated wound inspection. NICE advises against emergency department irrigation of open long-bone, hindfoot, or midfoot fractures before operative wound excision. [20]",
        "Attempt immediate reduction when fracture displacement is thought to compromise vascular flow. Persistent hard signs of vascular injury—absent palpable pulse, continued blood loss, or expanding hematoma—require immediate surgical exploration; do not rely on capillary refill or Doppler signal to exclude vascular injury, and do not delay revascularization for angiography. [20]"
      ],
      "bullets": [
        "Give IV prophylactic antibiotics immediately if not already administered. [20]",
        "Assess tetanus immunization status and provide toxoid and, when indicated, tetanus immune globulin. [22]",
        "Consult orthopaedic trauma surgery promptly; severe lower-extremity injuries should trigger early orthoplastic planning where available. [19][20]"
      ],
      "subsections": [],
      "table": {
        "caption": "Immediate actions for suspected open fracture [20][22]",
        "columns": [
          "Problem",
          "Action",
          "Escalation trigger"
        ],
        "rows": [
          [
            "Possible open fracture",
            "Treat any fracture with a concomitant wound as open until proven otherwise; cover, splint, obtain radiographs, and give antibiotics. [22]",
            "High-energy mechanism, extensive contamination, bone exposure, or soft-tissue loss warrants urgent trauma and orthopaedic evaluation. [19][22]"
          ],
          [
            "Persistent ischemia",
            "Reduce malalignment or dislocation if contributing to vascular compression. [22]",
            "Persistent absent pulse, ongoing bleeding, or expanding hematoma: immediate surgical exploration; do not delay for angiography. [20]"
          ],
          [
            "Risk of compartment syndrome",
            "Perform serial clinical assessments; use continuous pressure monitoring when symptoms cannot be assessed reliably. [20]",
            "Maintain surveillance for 48 hours after tibial fracture or fixation. [20]"
          ]
        ]
      }
    },
    {
      "id": "antibiotic-prophylaxis",
      "eyebrow": "Infection prevention",
      "heading": "Antibiotic prophylaxis and tetanus prevention",
      "intro": "Early systemic antibiotics complement, but never replace, operative debridement and stabilization.",
      "paragraphs": [
        "Cefazolin-based prophylaxis is the usual foundation because staphylococci are common fracture-related infection pathogens. A recent OTA review recommends antibiotics within 60 minutes before surgery and continuation for up to 24 hours after surgery; it notes that type III open fractures may benefit from brief gram-negative expansion. [19]",
        "For Gustilo types I and II, gram-positive coverage with cefazolin or cefuroxime is recommended in the supplied open-fracture review. For type III injuries, add gram-negative coverage; gentamicin is a commonly used option. Add high-dose penicillin for farmyard, fecal, or suspected clostridial contamination; clindamycin is an alternative for true penicillin allergy. [22]",
        "The supplied sources do not provide a current U.S. society-endorsed dose regimen for cefazolin, gentamicin, or penicillin in this setting. Use local trauma/antimicrobial stewardship protocols, renal function, allergy history, injury contamination, and planned repeat operations to select agents and duration. Routine prolonged systemic therapy without evidence of established infection is not supported by the cited contemporary review. [19]"
      ],
      "bullets": [
        "Administer prophylaxis as soon as possible, ideally before operative intervention. [19][20][22]",
        "Consider local antibiotics for high-energy or severe open fractures as an adjunct; evidence supports reduced infection in selected high-risk injuries, but local therapy does not replace systemic prophylaxis or debridement. [19]",
        "Assess tetanus status in every open fracture. Give tetanus toxoid if the primary series is incomplete or no booster was received within 5 years; for high-risk clostridial contamination or booster interval exceeding 10 years, administer toxoid plus tetanus immune globulin. [22]"
      ],
      "subsections": [],
      "table": {
        "caption": "Antimicrobial selection principles for open fractures [19][22]",
        "columns": [
          "Injury context",
          "Suggested coverage",
          "Important limitation"
        ],
        "rows": [
          [
            "Gustilo I-II",
            "Gram-positive coverage with cefazolin or cefuroxime. [22]",
            "Use local dosing and allergy protocols; source does not provide current dose details. [22]"
          ],
          [
            "Gustilo III",
            "Gram-positive coverage plus gram-negative coverage; gentamicin is commonly used. [19][22]",
            "Balance expanded coverage against renal toxicity and local resistance patterns. [19]"
          ],
          [
            "Farmyard, fecal, or suspected clostridial contamination",
            "Add high-dose penicillin; clindamycin is an alternative for true penicillin allergy. [22]",
            "Antibiotics do not substitute for urgent operative decontamination. [19][22]"
          ]
        ]
      }
    },
    {
      "id": "operative-management",
      "eyebrow": "Surgical strategy",
      "heading": "Debridement, irrigation, and skeletal stabilization",
      "intro": "The goal is a clean, viable wound bed with durable stability and an integrated plan for coverage.",
      "paragraphs": [
        "Perform meticulous operative wound excision of nonviable and contaminated tissue. Debridement should evaluate skin, subcutaneous tissue, fascia, muscle, and bone; remove necrotic tissue and foreign material while preserving viable structures. Repeat debridement may be required until all nonviable tissue is removed. [19]",
        "The timing of debridement should be individualized. Contemporary evidence from the FLOW cohort found no significant difference in reoperation between early and later debridement after adjustment for injury severity, undermining a rigid 6-hour cutoff. However, highly contaminated injuries, vascular injury, and suspected compartment syndrome require immediate operative management. NICE recommends wound excision immediately for highly contaminated injuries, within 12 hours for high-energy type IIIA/IIIB injuries that are not highly contaminated, and within 24 hours for other open fractures. [19][20]",
        "Use copious normal saline for operative irrigation. In the FLOW trial, reoperation rates did not differ by high, low, or very-low irrigation pressure, whereas castile soap was associated with more reoperations than normal saline. [19]",
        "Choose fixation based on physiology, contamination, fracture pattern, soft-tissue injury, and access to reconstruction. External fixation is useful for damage control, severe soft-tissue injury, vascular injury, and staged management. Definitive internal fixation is commonly appropriate for many Gustilo I, II, and IIIA injuries after adequate debridement; type IIIB/IIIC injuries often require staged fixation coordinated with flap coverage. [19]"
      ],
      "bullets": [
        "Place temporary external-fixator pins outside the zone of injury and away from anticipated definitive surgical approaches. [16][19]",
        "Do not assume an open fracture has decompressed all compartments; compartment syndrome can still occur. [8][20]",
        "For tibial fractures, serial assessment for compartment syndrome should continue for 48 hours after injury or fixation. [20]"
      ],
      "subsections": [
        {
          "heading": "Limb salvage versus amputation",
          "paragraphs": [
            "Do not use an injury severity score alone to determine amputation versus salvage. NICE recommends multidisciplinary orthopaedic, plastic surgery, rehabilitation, and patient/family assessment when feasible. Emergency amputation is indicated for uncontrollable life-threatening hemorrhage, when salvage would pose unacceptable risk to life, or when orthoplastic assessment determines the limb is unsalvageable. [20]"
          ],
          "bullets": [
            "If delayed primary amputation is chosen, NICE recommends completion within 72 hours of injury. [20]"
          ]
        }
      ],
      "table": {
        "caption": "Fixation approach by common clinical scenario [19][20]",
        "columns": [
          "Scenario",
          "Preferred strategic objective",
          "Typical construct role"
        ],
        "rows": [
          [
            "Physiologic instability or damage-control setting",
            "Rapid restoration of alignment and access to resuscitation. [19]",
            "Temporary external fixation. [19]"
          ],
          [
            "Gustilo I-II and selected IIIA injuries after adequate debridement",
            "Definitive stability with early mobilization and maintenance of reduction. [19]",
            "Single-stage internal fixation is commonly used. [19]"
          ],
          [
            "Type IIIB/IIIC injury or need for flap coverage",
            "Coordinate debridement, skeletal stability, vascular management, and timely coverage. [19][20]",
            "Temporary fixation or staged definitive fixation; minimize interval between definitive fixation and flap coverage. [19]"
          ]
        ]
      }
    },
    {
      "id": "soft-tissue-coverage",
      "eyebrow": "Orthoplastic care",
      "heading": "Definitive coverage is time-sensitive",
      "intro": "Stable fixation and durable soft-tissue coverage should be planned as one reconstructive problem.",
      "paragraphs": [
        "Definitive soft-tissue coverage protects exposed bone, tendon, vessels, and implants while reducing fracture-related infection risk. Early coverage—preferably within 3 to 5 days in the cited OTA review—reduces deep infection and nonunion; delay beyond 7 days has been associated with increased complications. [19]",
        "NICE recommends concurrent orthopaedic and plastic surgery management for open long-bone, hindfoot, and midfoot fractures. Perform definitive fixation and soft-tissue coverage at wound excision when feasible; otherwise provide definitive cover within 72 hours of injury. When internal fixation is used, definitive soft-tissue coverage should occur at the same time. [20]",
        "Negative-pressure wound therapy may be a useful temporary dressing but should not be interpreted as permission to defer definitive coverage. The updated NICE recommendation is to use a temporary dressing that prevents desiccation and minimizes dressing changes; it does not endorse a specific dressing type. [20]"
      ],
      "bullets": [
        "Split-thickness skin grafting requires a vascular wound bed and generally should not be placed over denuded bone or exposed hardware. [19]",
        "Local or rotational muscle, fasciocutaneous, perforator, and free flaps are selected according to defect location, dimensions, exposed structures, and available viable tissue. [19]",
        "Early referral or transfer to a center capable of orthoplastic reconstruction is appropriate when coverage resources are unavailable locally. [19][20]"
      ],
      "subsections": [],
      "table": {
        "caption": "Coverage decisions after operative debridement [19][20]",
        "columns": [
          "Wound characteristic",
          "Coverage implication",
          "Temporary measure if coverage cannot occur immediately"
        ],
        "rows": [
          [
            "Vascularized wound bed without exposed bone, hardware, tendon, artery, or nerve",
            "Split-thickness skin graft may be appropriate. [19]",
            "Dressing that prevents desiccation and minimizes dressing changes. [20]"
          ],
          [
            "Exposed bone, tendon, or implant",
            "Requires vascularized tissue coverage or an intermediate reconstructive strategy. [19]",
            "Temporary dressing only while arranging definitive coverage; avoid using NPWT as a rationale for prolonged delay. [19][20]"
          ],
          [
            "Severe type IIIB injury",
            "Coordinate fixation and flap coverage closely to reduce infection risk. [19][20]",
            "Staged fixation and temporary wound management as needed. [19][20]"
          ]
        ]
      }
    },
    {
      "id": "monitoring-and-complications",
      "eyebrow": "Postoperative surveillance",
      "heading": "Monitor for limb, wound, and systemic complications",
      "intro": "The early postoperative plan should detect ischemia, compartment syndrome, infection, and fixation failure before irreversible harm.",
      "paragraphs": [
        "Repeat and document neurovascular examinations, especially after reduction, splinting, external fixation, or changes in swelling. For tibial fractures, clinical surveillance for compartment syndrome should continue through 48 hours after injury or fixation; use continuous pressure monitoring when symptoms are not reliable because of unconsciousness or regional anesthesia. [20]",
        "Fracture-related infection risk increases with diabetes, peripheral vascular disease, smoking, malnutrition, obesity, and immunosuppression. Identify modifiable host risks and optimize nutrition, smoking cessation, and glycemic control where possible. [19]",
        "Open fractures can progress to infection, nonunion, malunion, osteomyelitis, vascular compromise, compartment syndrome, and limb loss. Persistent wound drainage, progressive pain, systemic illness, recurrent swelling, loss of fixation, or failure of radiographic progression should prompt reassessment for infection, inadequate stability, occult devitalized tissue, or insufficient coverage. [19][22]"
      ],
      "bullets": [
        "Use multidisciplinary rehabilitation planning early for severe limb injury, including weight-bearing restrictions, mobility aids, wound care, pain control, and psychological support. [20]",
        "Document wound photographs and repeated neurovascular findings when permitted by institutional policy; images may support transfer and orthoplastic planning. [20]"
      ],
      "subsections": [],
      "table": {
        "caption": "High-value monitoring after open fracture stabilization [19][20]",
        "columns": [
          "Monitor",
          "When",
          "Action if abnormal"
        ],
        "rows": [
          [
            "Neurovascular status",
            "Before and after reduction or splinting, then serially. [20]",
            "Persistent hard vascular signs require urgent surgical management. [20]"
          ],
          [
            "Compartment syndrome signs",
            "Serially for 48 hours after tibial fracture or fixation. [20]",
            "Use pressure monitoring when examination is unreliable; urgent fasciotomy is the accepted treatment when compartment syndrome is diagnosed. [8]"
          ],
          [
            "Soft-tissue viability and wound contamination",
            "At each operative debridement and dressing assessment. [19]",
            "Return for repeat debridement if nonviable tissue remains or evolves. [19]"
          ],
          [
            "Host infection risks",
            "Perioperatively and during recovery. [19]",
            "Optimize modifiable factors and maintain low threshold for infection evaluation. [19]"
          ]
        ]
      }
    }
  ],
  "faq": [
    {
      "question": "Does every open fracture need immediate operative debridement within 6 hours?",
      "answer": "No. A fixed 6-hour threshold is not supported by contemporary evidence. Urgency should be highest for highly contaminated wounds, vascular injury, suspected compartment syndrome, or unstable physiology. NICE recommends immediate excision for highly contaminated injuries, within 12 hours for high-energy IIIA/IIIB injuries, and within 24 hours for other open fractures. [19][20]"
    },
    {
      "question": "Should an open fracture wound be irrigated in the emergency department?",
      "answer": "For open long-bone, hindfoot, and midfoot fractures, NICE recommends against emergency department irrigation before operative wound excision. Apply a saline-soaked sterile dressing with occlusive coverage, splint, administer antibiotics, and minimize repeat wound exposure. [20]"
    },
    {
      "question": "When is external fixation preferred?",
      "answer": "External fixation is particularly useful for damage-control stabilization, physiologic instability, severe soft-tissue injury, vascular injury, and staged reconstruction. Definitive internal fixation is commonly used after adequate debridement for many Gustilo I, II, and selected IIIA injuries. [19]"
    },
    {
      "question": "Can negative-pressure wound therapy delay flap coverage?",
      "answer": "No. NPWT may help temporize an open wound, but it is not a substitute for definitive coverage. Use a temporary dressing that avoids desiccation and minimizes dressing changes while arranging timely soft-tissue reconstruction. [19][20]"
    },
    {
      "question": "Should amputation be decided from a mangled-extremity score?",
      "answer": "No. NICE recommends not basing salvage versus amputation on an injury severity score alone. Decisions should incorporate orthopaedic, plastic surgery, rehabilitation, patient, and family perspectives when feasible, unless urgent life-threatening hemorrhage mandates emergency amputation. [20]"
    }
  ],
  "references": [
    {
      "number": 1,
      "title": "This label may not be the latest approved by FDA. For current ...",
      "detail": "www.accessdata.fda.gov",
      "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021345s037lbl.pdf",
      "authors": "www.accessdata.fda.gov",
      "host": "www.accessdata.fda.gov"
    },
    {
      "number": 2,
      "title": "These highlights do not include all the information needed to use ALENDRONATE SODIUM TABLETS safely and effectively. See full prescribing information for ALENDRONATE SODIUM TABLETS. <br/> <br/> ALENDRONATE SODIUM tablets, for oral use <br/> Initial U.S. Approval:1995",
      "detail": "nctr-crs.fda.gov",
      "url": "https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/c4358ba7-1bf8-4b0a-9407-5ac279d04555/spl-doc?hl=",
      "authors": "nctr-crs.fda.gov",
      "host": "nctr-crs.fda.gov"
    },
    {
      "number": 3,
      "title": "METHOTREXATE label - accessdata.fda.gov",
      "detail": "www.accessdata.fda.gov",
      "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf",
      "authors": "www.accessdata.fda.gov",
      "host": "www.accessdata.fda.gov"
    },
    {
      "number": 4,
      "title": "FDA adds Boxed Warning for increased risk of severe hypocalcemia in patients with advanced chronic kidney disease taking osteoporosis medicine Prolia (denosumab) | FDA",
      "detail": "www.fda.gov",
      "url": "https://www.fda.gov/drugs/drug-safety-communications/fda-adds-boxed-warning-increased-risk-severe-hypocalcemia-patients-advanced-chronic-kidney-disease",
      "authors": "www.fda.gov",
      "host": "www.fda.gov"
    },
    {
      "number": 5,
      "title": "Orthopaedic traumatology: fundamental principles and current controversies for the acute care surgeon | Trauma Surgery & Acute Care Open",
      "detail": "tsaco.bmj.com",
      "url": "https://tsaco.bmj.com/content/3/1/e000117",
      "authors": "tsaco.bmj.com",
      "host": "tsaco.bmj.com"
    },
    {
      "number": 6,
      "title": "Fracture risk tools performance and potential use in ...",
      "detail": "lupus.bmj.com",
      "url": "https://lupus.bmj.com/content/lupusscimed/13/1/e001904.full.pdf",
      "authors": "lupus.bmj.com",
      "host": "lupus.bmj.com"
    },
    {
      "number": 7,
      "title": "Pinckney fracture: do not underestimate trauma of the distal phalanx of the hallux | BMJ Case Reports",
      "detail": "casereports.bmj.com",
      "url": "https://casereports.bmj.com/content/14/9/e244985",
      "authors": "casereports.bmj.com",
      "host": "casereports.bmj.com"
    },
    {
      "number": 8,
      "title": "Lower extremity compartment syndrome | Trauma Surgery & Acute Care Open",
      "detail": "tsaco.bmj.com",
      "url": "https://tsaco.bmj.com/content/2/1/e000094",
      "authors": "tsaco.bmj.com",
      "host": "tsaco.bmj.com"
    },
    {
      "number": 9,
      "title": "Prognostic model and U-shaped SBP-risk correlation in unstable pelvic fractures with TBI | npj Digital Medicine",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41746-025-02249-y",
      "authors": "www.nature.com",
      "host": "www.nature.com"
    },
    {
      "number": 10,
      "title": "Establishment and application of TSDPSO-SVM model ...",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-023-46526-w",
      "authors": "www.nature.com",
      "host": "www.nature.com"
    },
    {
      "number": 11,
      "title": "Critical evaluation of deep neural networks for wrist fracture ...",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-021-85570-2",
      "authors": "www.nature.com",
      "host": "www.nature.com"
    },
    {
      "number": 12,
      "title": "High sensitivity methods for automated rib fracture detection in pediatric radiographs | Scientific Reports",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-024-59077-5",
      "authors": "www.nature.com",
      "host": "www.nature.com"
    },
    {
      "number": 13,
      "title": "Acute Lower Extremity Fracture Management in... : JBJS Open Access",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/jbjsoa/fulltext/2022/12000/acute_lower_extremity_fracture_management_in.14.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com"
    },
    {
      "number": 14,
      "title": "Hip fracture care and national systems : OTA International: The Open Access Journal of Orthopaedic Trauma",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/otainternational/fulltext/2020/03000/hip_fracture_care_and_national_systems__the_united.6.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com"
    },
    {
      "number": 15,
      "title": "Appraisal of Clinical Practice Guideline: American Academy of Orthopaedic Surgeons Clinical Practice Guideline on the Management of Osteoarthritis of the Hip - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/pii/S1836955318300389",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com"
    },
    {
      "number": 16,
      "title": "Management of open fractures: A narrative review - PMC",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10502353",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov"
    },
    {
      "number": 17,
      "title": "Standardising the management of open extremity fractures: a scoping review of national guidelines",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10276057",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov"
    },
    {
      "number": 18,
      "title": "Treatment principles in the management of open fractures - PMC",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2740354",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov"
    },
    {
      "number": 19,
      "title": "Open fractures: evidence-based best practices - PMC",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11064778",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov"
    },
    {
      "number": 20,
      "title": "Fractures (complex): assessment and management - NCBI - NIH",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK555104",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov"
    },
    {
      "number": 21,
      "title": "Scope - Fractures (Non-Complex): Assessment and Management - NCBI Bookshelf",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK368143",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov"
    },
    {
      "number": 22,
      "title": "Open Fracture Management - StatPearls - NCBI Bookshelf - NIH",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK448083",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov"
    },
    {
      "number": 23,
      "title": "Glossary and abbreviations - Addendum to Clinical Guideline 124, Hip fracture: management - NCBI Bookshelf",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK550536",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov"
    },
    {
      "number": 24,
      "title": "Fixing more than bones: The role of antibiotic stewardship ...",
      "detail": "www.idsociety.org",
      "url": "https://www.idsociety.org/science-speaks-blog/2025/fixing-more-than-bones-the-role-of-antibiotic-stewardship-in-open-fractures",
      "authors": "www.idsociety.org",
      "host": "www.idsociety.org"
    }
  ],
  "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.",
  "citations": [
    {
      "number": 1,
      "title": "This label may not be the latest approved by FDA. For current ...",
      "detail": "www.accessdata.fda.gov",
      "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021345s037lbl.pdf",
      "authors": "www.accessdata.fda.gov",
      "host": "www.accessdata.fda.gov",
      "snippet": "are more likely to have reduced renal function, ARIXTRA should be used with caution in these patients. (8.5) • The risk of bleeding is increased with reduced renal or hepatic function. (8.6, 8.7) See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling. Revised: 12/2019 1 Referenc",
      "score": 0.48074743
    },
    {
      "number": 2,
      "title": "These highlights do not include all the information needed to use ALENDRONATE SODIUM TABLETS safely and effectively. See full prescribing information for ALENDRONATE SODIUM TABLETS. <br/> <br/> ALENDRONATE SODIUM tablets, for oral use <br/> Initial U.S. Approval:1995",
      "detail": "nctr-crs.fda.gov",
      "url": "https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/c4358ba7-1bf8-4b0a-9407-5ac279d04555/spl-doc?hl=",
      "authors": "nctr-crs.fda.gov",
      "host": "nctr-crs.fda.gov",
      "snippet": "8.6 Renal Impairment  Alendronate sodium is not recommended for patients with creatinine clearance less than 35 mL/min .No dosage adjustment is necessary in patients with creatinine clearance values between 35-60 mL/min [see Clinical Pharmacology ( 12.3)] .\n\n \n\n8.7 Hepatic Impairment  As there is ev",
      "score": 0.20424701
    },
    {
      "number": 3,
      "title": "METHOTREXATE label - accessdata.fda.gov",
      "detail": "www.accessdata.fda.gov",
      "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf",
      "authors": "www.accessdata.fda.gov",
      "host": "www.accessdata.fda.gov",
      "snippet": "TOXICOLOGY 8.3 Females and Males of Reproductive Potential 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 8.4 Pediatric Use 15 REFERENCES 8.5 Geriatric Use 16 HOW SUPPLIED/STORAGE AND HANDLING 8.6 Renal Impairment 17 PATIENT COUNSELING INFORMATION 8.7 Hepatic Impairment 10 OVERDOSAGE Sect",
      "score": 0.15330847
    },
    {
      "number": 4,
      "title": "FDA adds Boxed Warning for increased risk of severe hypocalcemia in patients with advanced chronic kidney disease taking osteoporosis medicine Prolia (denosumab) | FDA",
      "detail": "www.fda.gov",
      "url": "https://www.fda.gov/drugs/drug-safety-communications/fda-adds-boxed-warning-increased-risk-severe-hypocalcemia-patients-advanced-chronic-kidney-disease",
      "authors": "www.fda.gov",
      "host": "www.fda.gov",
      "snippet": "## What should health care professionals do?\n\nIt is important that the appropriateness of Prolia treatment in patients with advanced CKD be determined by a health care professional with expertise in the diagnosis and management of CKD-MBD including renal osteodystrophy, a complication that weakens b",
      "score": 0.13125141
    },
    {
      "number": 5,
      "title": "Orthopaedic traumatology: fundamental principles and current controversies for the acute care surgeon | Trauma Surgery & Acute Care Open",
      "detail": "tsaco.bmj.com",
      "url": "https://tsaco.bmj.com/content/3/1/e000117",
      "authors": "tsaco.bmj.com",
      "host": "tsaco.bmj.com",
      "snippet": "Figure 1\n\n(A) Lateral radiograph of the wrist-apex volar angulation (dorsal displacement) of comminuted distal radius fracture. (B) Anteroposterior radiograph of tibia/fibula - apex medial angulation (valgus) of simple, diaphyseal tibia fracture. (C) Lateral radiograph of tibia/fibula – apex anterio",
      "score": 0.31538844
    },
    {
      "number": 6,
      "title": "Fracture risk tools performance and potential use in ...",
      "detail": "lupus.bmj.com",
      "url": "https://lupus.bmj.com/content/lupusscimed/13/1/e001904.full.pdf",
      "authors": "lupus.bmj.com",
      "host": "lupus.bmj.com",
      "snippet": "An additional novel finding is the proposal of a risk-­ based threshold to guide the diagnostic search for unrec-ognised vertebral fractures. Thresholds are routinely used in osteoporosis guidelines to determine therapeutic interventions, such as the fixed FRAX MOF ≥20% cut-­ off in the USA34 or the",
      "score": 0.3004381
    },
    {
      "number": 7,
      "title": "Pinckney fracture: do not underestimate trauma of the distal phalanx of the hallux | BMJ Case Reports",
      "detail": "casereports.bmj.com",
      "url": "https://casereports.bmj.com/content/14/9/e244985",
      "authors": "casereports.bmj.com",
      "host": "casereports.bmj.com",
      "snippet": "We report a case of a patient that was admitted to the hospital with a Salter-Harris type I fracture of the distal phalanx of the hallux. After confirming the diagnosis, antibiotic treatment was started and the fracture was reduced and fixed.\n\nThe literature on this entity is sparse and most of the ",
      "score": 0.23244122
    },
    {
      "number": 8,
      "title": "Lower extremity compartment syndrome | Trauma Surgery & Acute Care Open",
      "detail": "tsaco.bmj.com",
      "url": "https://tsaco.bmj.com/content/2/1/e000094",
      "authors": "tsaco.bmj.com",
      "host": "tsaco.bmj.com",
      "snippet": "Traditionally, an intramuscular compartment pressure of >30 mm Hg was used as a diagnostic threshold for diagnosing compartment syndrome, although the absolute pressure value has been debated.23–25 However, the accuracy of using single compartment pressure data points has been called into question.2",
      "score": 0.23157988
    },
    {
      "number": 9,
      "title": "Prognostic model and U-shaped SBP-risk correlation in unstable pelvic fractures with TBI | npj Digital Medicine",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41746-025-02249-y",
      "authors": "www.nature.com",
      "host": "www.nature.com",
      "snippet": "cerebral perfusion, significantly increasing the risk of secondary brain injury; Abnormal hypertension after severe trauma may also be associated with poor prognosis by exacerbating intracranial injury or reflecting severe stress response. Figure 14 shows that PT exhibits a clear threshold effect. W",
      "score": 0.18746005
    },
    {
      "number": 10,
      "title": "Establishment and application of TSDPSO-SVM model ...",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-023-46526-w",
      "authors": "www.nature.com",
      "host": "www.nature.com",
      "snippet": "by X Hu · 2023 · Cited by 5 — In patients with open fractures, the presence of a wound indicates a high risk of fracture contact and soft tissue injury, which may induce post",
      "score": 0.13279572
    },
    {
      "number": 11,
      "title": "Critical evaluation of deep neural networks for wrist fracture ...",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-021-85570-2",
      "authors": "www.nature.com",
      "host": "www.nature.com",
      "snippet": "by AM Raisuddin · 2021 · Cited by 109 — We develop an open-source wrist fracture diagnosis method—DeepWrist (see Fig. 1). This method is a two-stage pipeline, which utilizes",
      "score": 0.12762025
    },
    {
      "number": 12,
      "title": "High sensitivity methods for automated rib fracture detection in pediatric radiographs | Scientific Reports",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-024-59077-5",
      "authors": "www.nature.com",
      "host": "www.nature.com",
      "snippet": "Our preliminary work proposed adjusting the decision threshold for fracture positive proposals as a function of the number of already accepted bounding box proposals9 611 – 618. [...] We explored different relationships for decision thresholds versus apparent number of accepted fractures as presente",
      "score": 0.11489404
    },
    {
      "number": 13,
      "title": "Acute Lower Extremity Fracture Management in... : JBJS Open Access",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/jbjsoa/fulltext/2022/12000/acute_lower_extremity_fracture_management_in.14.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "the care of persons with an SCI also independently reviewed the guidelines. This outside advisory panel included 1 endocrinologist and 2 orthopaedic surgeons. Suggestions from this expert outside advisory panel resulted in the inclusion of information on exoskeleton use and foot fractures and clinic",
      "score": 0.52173984
    },
    {
      "number": 14,
      "title": "Hip fracture care and national systems : OTA International: The Open Access Journal of Orthopaedic Trauma",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/otainternational/fulltext/2020/03000/hip_fracture_care_and_national_systems__the_united.6.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "## 1 Introduction\n\nIt is widely accepted that geriatric hip fractures are at endemic levels. While hip fractures occur more commonly in Europe, Canada, and the United States, it is expected that these numbers will increase globally due to demographic changes. Annually, it is estimated that there are",
      "score": 0.21270628
    },
    {
      "number": 15,
      "title": "Appraisal of Clinical Practice Guideline: American Academy of Orthopaedic Surgeons Clinical Practice Guideline on the Management of Osteoarthritis of the Hip - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/pii/S1836955318300389",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "# Appraisal Appraisal of Clinical Practice Guideline: American Academy of Orthopaedic Surgeons Clinical Practice Guideline on the Management of Osteoarthritis of the Hip. Author links open overlay panel, Joy C MacDermid b. **Patient group**: Adult patients (age ≥ 18 years) with osteoarthritis of the",
      "score": 0.20515321
    },
    {
      "number": 16,
      "title": "Management of open fractures: A narrative review - PMC",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10502353",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov",
      "snippet": "## 1. Introduction\n\nAn open fracture is an injury where the fractured bone and/or hematoma are exposed to the external environment through a traumatic violation of the soft tissue and skin1. The spectrum of open fractures can vary from cases that achieve primary closure after debridement to more com",
      "score": 0.6546525
    },
    {
      "number": 17,
      "title": "Standardising the management of open extremity fractures: a scoping review of national guidelines",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10276057",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov",
      "snippet": "Two of these guidelines covered recommendations for antibiotic prophylaxis only [15, 16], while one focused on the management of combat-related injuries , all three being developed by organisations based in the USA. The remaining nine covered the overall management of open fractures. Of these, three",
      "score": 0.604703
    },
    {
      "number": 18,
      "title": "Treatment principles in the management of open fractures - PMC",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2740354",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov",
      "snippet": "| Bone | Remove all devitalized bone. The ends of the bone should be delivered into the wound and cleaned/debrided. Devitalized fragments of bone should be removed. Large portions of cancellous bone can be cleaned and used as graft material (only if not directly involved in the open fracture environ",
      "score": 0.5297749
    },
    {
      "number": 19,
      "title": "Open fractures: evidence-based best practices - PMC",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11064778",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov",
      "snippet": "PMC Copyright notice\n\nPMCID: PMC11064778 PMID: 38708043\n\n##  is the leading morbid complication to avoid during open fracture management because it leads to sepsis, nonunion, limb loss, and overall very poor region-specific and general functional outcomes. This review, based on a symposium presented",
      "score": 0.48499045
    },
    {
      "number": 20,
      "title": "Fractures (complex): assessment and management - NCBI - NIH",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK555104",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov",
      "snippet": "This guideline is the basis of QS166.\n\n## Overview\n\nThis guideline covers assessing and managing pelvic fractures, open fractures and severe ankle fractures (known as pilon fractures and intra-articular distal tibia fractures) in pre-hospital settings (including ambulance services), emergency depart",
      "score": 0.4475333
    },
    {
      "number": 21,
      "title": "Scope - Fractures (Non-Complex): Assessment and Management - NCBI Bookshelf",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK368143",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov",
      "snippet": "This scope defines what the guideline will (and will not) examine, and what the guideline developers will consider. The scope is based on the referral from the Department of Health.\n\nThe areas that will be addressed by the guideline are described in the following sections.\n\n### 4.1. Population\n\n####",
      "score": 0.4122231
    },
    {
      "number": 22,
      "title": "Open Fracture Management - StatPearls - NCBI Bookshelf - NIH",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK448083",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov",
      "snippet": "## Introduction\n\nAn open fracture is an injury where the fractured bone and/or fracture hematoma are exposed to the external environment via a traumatic violation of the soft tissue and skin. The skin wound may lie at a site distant to the fracture and not directly over it. Therefore, any fracture t",
      "score": 0.39089483
    },
    {
      "number": 23,
      "title": "Glossary and abbreviations - Addendum to Clinical Guideline 124, Hip fracture: management - NCBI Bookshelf",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "https://www.ncbi.nlm.nih.gov/books/NBK550536",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov",
      "snippet": "a fracture of the head or neck of the femur, which is contained within the capsule of the hip joint.\n\ndescribing the direction of projection (perpendicular to the midsagittal plane which vertically bisects the body) so that the x-ray image is a side-on view of the patient.\n\nthe reduction and interna",
      "score": 0.35113358
    },
    {
      "number": 24,
      "title": "Fixing more than bones: The role of antibiotic stewardship ...",
      "detail": "www.idsociety.org",
      "url": "https://www.idsociety.org/science-speaks-blog/2025/fixing-more-than-bones-the-role-of-antibiotic-stewardship-in-open-fractures",
      "authors": "www.idsociety.org",
      "host": "www.idsociety.org",
      "snippet": "However, open fractures present unique considerations that complicate both the evidence for and the approach to antimicrobial therapy. The key is balance — providing effective antibiotic coverage to prevent these infections, while also maintaining antibiotic stewardship to minimize resistance and ad",
      "score": 0.25416678
    }
  ],
  "publishedAt": "2026-08-20T23:26:36.702337Z",
  "updatedAt": "2026-08-20T23:26:36.702337Z",
  "readingMinutes": 6,
  "slug": "open-fracture-management"
}