{ "schemaVersion": 2, "eyebrow": "Medical Toxicology", "title": "Methanol Toxicity", "summary": "Suspect methanol toxicity in unexplained high-anion-gap acidosis, especially with visual symptoms or an elevated osmolar gap. Start alcohol dehydrogenase blockade and bicarbonate immediately when clinically suspected; use hemodialysis for severe acidosis, organ toxicity, or impaired clearance.", "seoDescription": "Physician guide to recognizing methanol toxicity, interpreting osmolar and anion gaps, initiating fomepizole or ethanol, and selecting hemodialysis.", "clinicalQuestion": "How should clinicians diagnose and urgently treat suspected methanol toxicity before confirmatory concentrations are available?", "specialty": "Medical Toxicology", "audience": "U.S. physicians and medical trainees", "tags": [ "methanol poisoning", "toxic alcohols", "fomepizole", "anion gap metabolic acidosis", "osmolar gap", "hemodialysis", "formate" ], "keyTakeaways": [ "Treat a credible methanol exposure with high-anion-gap metabolic acidosis, visual toxicity, or an increased osmolar gap as an antidote emergency; do not wait for symptoms or a confirmatory methanol concentration. [5][16][22]", "Fomepizole blocks alcohol dehydrogenase and is generally easier to administer than ethanol; the cited regimen is 15 mg/kg loading, then 10 mg/kg every 12 hours for four doses, then 15 mg/kg every 12 hours while indicated. [16][24]", "Give intravenous sodium bicarbonate for significant acidosis or ophthalmologic abnormalities, because formic acid drives acidosis and ocular toxicity. [22]", "Add intermittent hemodialysis for severe acidosis, renal dysfunction, or substantial toxicity; historical guidance uses methanol concentration above 50 mg/dL as a dialysis threshold, although antidote-treated patients with normal pH and no symptoms may not invariably require dialysis solely for that level. [9][14][16]", "A normal or minimally elevated osmolar gap does not exclude advanced methanol toxicity, because the parent alcohol falls as formate accumulation raises the anion gap. [11][17]" ], "sections": [ { "id": "recognize-and-stabilize", "eyebrow": "Emergency Action", "heading": "When to treat suspected methanol exposure immediately", "intro": "Prioritize metabolic severity and visual findings over certainty about the ingested product.", "paragraphs": [ "Initiate resuscitation and toxic alcohol treatment when a patient has a compatible ingestion or exposure plus unexplained metabolic acidosis, visual disturbance, or a combined osmolar and anion gap. Methanol is found in some cleaning products, antifreeze-related products, illicit or contaminated alcoholic beverages, and contaminated hand sanitizers. Ingestion is the usual route, but inhalational and dermal poisonings are reported rarely. [1][6][19][22]", "Obtain airway and ventilatory support when mental status or respiratory compensation is failing. Severe methanol poisoning can progress from nausea, vomiting, headache, dizziness, and ataxia to seizures, coma, permanent neurologic injury, blindness, and death. A latent interval of approximately 12 to 24 hours may precede uncompensated acidosis and visual dysfunction; concurrent ethanol can delay this evolution. [1][20][22]", "Contact a poison center or medical toxicologist while drawing diagnostic studies, but administer an alcohol dehydrogenase inhibitor without waiting for a methanol result when suspicion is strong. Early blocking-agent administration is time-sensitive because toxicity results from metabolic conversion to formic acid rather than from methanol alone. [3][16][22]" ], "bullets": [ "Ask specifically about windshield fluid, solvents, industrial alcohol, cleaning agents, hand sanitizer ingestion, and shared alcoholic beverages; outbreaks can involve adulterated alcohol. [1][6]", "Perform and document visual acuity, pupils, visual fields when feasible, and funduscopic findings; blurred vision, field defects, or blindness indicate clinically important formate toxicity. [6][22]", "Send the product container or a specimen for identification when available, but never make product testing a prerequisite for antidote treatment. [1][16]" ], "subsections": [], "table": { "caption": "Clinical findings that should accelerate antidote therapy and dialysis planning. [1][16][22]", "columns": [ "Finding", "Interpretation", "Immediate action" ], "rows": [ [ "Visual symptoms or objective ophthalmologic abnormality", "Formic acid is the principal driver of ocular toxicity; impairment may progress to blindness. [6][22]", "Give alcohol dehydrogenase blockade and IV sodium bicarbonate; arrange urgent dialysis assessment. [22]" ], [ "High-anion-gap metabolic acidosis", "Supports accumulated formate in the appropriate exposure context. [5][11][22]", "Start antidote and correct acidosis with IV sodium bicarbonate; assess for hemodialysis. [22]" ], [ "Increased osmolar gap", "Supports circulating low-molecular-weight parent alcohol early after ingestion. [5][11]", "Send a methanol concentration if available, but begin treatment when clinical suspicion is credible. [16]" ], [ "Renal dysfunction or severe acidosis", "Indicates severe poisoning and impaired physiologic reserve. [16]", "Use hemodialysis as an adjunct to antidote therapy. [16]" ] ] } }, { "id": "diagnostic-workup", "eyebrow": "Diagnostic Strategy", "heading": "Interpret osmolar gap, anion gap, and formate by time since ingestion", "intro": "Order paired metabolic and toxicologic testing immediately, but interpret a negative screen in clinical context.", "paragraphs": [ "Obtain basic metabolic panel with calculated anion gap, measured serum osmolality with calculated osmolarity, venous or arterial blood gas, ethanol concentration, and a quantitative methanol concentration where locally available. Anion gap and bicarbonate are an adequate initial screen for most acid-base disorders, while blood gas testing defines acidemia and respiratory compensation. [12]", "The diagnostic pattern changes as methanol is metabolized. Parent methanol increases the osmolar gap; formate increases the anion gap. In one series, both anion and osmolar gaps were elevated in 11 of 11 patients, but neither gap should be used as an exclusion test in isolation. [11][17]", "A high osmolar gap with little acidosis can reflect earlier presentation before substantial formate generation, whereas high-anion-gap acidosis with a lower osmolar gap can reflect later presentation after parent methanol has been consumed. Concurrent ethanol competitively inhibits metabolism and may prolong the latent period and alter the expected laboratory trajectory. [5][8][22]", "Interpret an elevated lactate cautiously in suspected toxic alcohol poisoning. Methanol or ethylene glycol can produce an osmolar gap plus anion-gap acidosis, and reported high lactate values may be analytically misleading in this setting. If the clinical pattern remains discordant, prioritize serial pH, bicarbonate, anion gap, osmolar gap, and direct methanol or formate testing rather than excluding toxic alcohol poisoning from a single lactate result. [2][5]" ], "bullets": [ "Trend bicarbonate, anion gap, pH, and osmolar gap after treatment begins; worsening acidosis or neurologic or ocular findings should accelerate extracorporeal treatment. [5][22]", "Measure serum formate when the assay is available; formic acid concentration correlates directly with morbidity and mortality in acute methanol toxicity. [11][22]", "Maintain ethylene glycol in the differential when osmolar-gap and anion-gap acidosis coexist; both conditions require prompt alcohol dehydrogenase blockade, but ethylene glycol is particularly associated with delayed renal injury. [4][5][16]" ], "subsections": [ { "heading": "Laboratory patterns that should not reassure", "paragraphs": [ "Do not exclude severe methanol poisoning because the osmolar gap is absent or modest. Severe cases may lack one or both classic gaps, and a falling osmolar gap can represent metabolism of methanol to formate rather than clinical improvement. [11][17]", "Do not use a normal early examination to defer treatment after a credible significant exposure. The clinically important interval before acidosis and visual dysfunction is commonly 12 to 24 hours, and early alcohol dehydrogenase blockade limits formation of toxic metabolites. [16][22]" ], "bullets": [] } ], "table": { "caption": "Time-dependent biochemical interpretation in suspected methanol toxicity. [5][11][22]", "columns": [ "Predominant pattern", "Likely toxicologic stage", "Decision implication" ], "rows": [ [ "Elevated osmolar gap with limited anion-gap acidosis", "Parent methanol remains prominent before extensive formate accumulation. [5][11]", "Treat on exposure and gap pattern; do not wait for acidosis or visual symptoms. [16]" ], [ "High-anion-gap metabolic acidosis with visual symptoms", "Formate accumulation and clinically significant toxicity. [19][22]", "Give antidote and IV sodium bicarbonate; plan urgent hemodialysis evaluation. [22]" ], [ "High anion gap with low or normal osmolar gap", "Later presentation after metabolism of parent methanol; classic screening gaps can be incomplete. [11][17]", "Continue toxic alcohol evaluation and treatment if exposure history or phenotype is compatible. [17][22]" ], [ "Osmolar and anion gaps with renal dysfunction", "Consider ethylene glycol as a competing or alternative toxic alcohol diagnosis. [5][16]", "Maintain alcohol dehydrogenase blockade and use hemodialysis for severe acidosis or renal dysfunction. [16]" ] ] } }, { "id": "antidote-and-acidosis", "eyebrow": "Antidotal Therapy", "heading": "Block alcohol dehydrogenase and correct acidemia", "intro": "Antidote therapy prevents additional formate production; bicarbonate addresses the immediate acid-base and toxicity consequences.", "paragraphs": [ "Use fomepizole as the preferred alcohol dehydrogenase inhibitor when available. The cited regimen is 15 mg/kg IV loading dose, followed 12 hours later by 10 mg/kg IV every 12 hours for four doses, then 15 mg/kg IV every 12 hours as long as treatment is required. Fomepizole has low toxicity and is easier to administer than ethanol; it is FDA-approved for methanol and ethylene glycol poisoning. [16][24]", "If fomepizole is unavailable, use ethanol to competitively inhibit alcohol dehydrogenase. Target a blood ethanol concentration of 100 to 150 mg/dL. The cited IV ethanol loading dose is 600 to 800 mg/kg; maintenance dosing depends on chronic alcohol use and must be increased during hemodialysis. [15]", "Give intravenous sodium bicarbonate for significant metabolic acidosis or ophthalmologic abnormalities. Formic acid is central to the acidosis and ocular injury of methanol poisoning, and correction of acidemia is specifically recommended in patients with significant acidosis or ophthalmologic findings. [22]", "Use folinic acid as an adjunct in severe methanol poisoning protocols, particularly when formate toxicity is present, but do not substitute it for antidotal blockade, bicarbonate, or extracorporeal removal when indicated. Recommended treatment descriptions include fomepizole or ethanol, folinic acid, sodium bicarbonate, and hemodialysis. [6][23]" ], "bullets": [ "During ethanol therapy, measure ethanol concentrations frequently enough to maintain the 100 to 150 mg/dL target; adjust maintenance dosing during hemodialysis. [15]", "Prefer fomepizole where available when frequent ethanol titration, intoxication, hypoglycemia, hypothermia, agitation, or intensive monitoring would complicate ethanol treatment. [10][23][24]", "Do not delay antidote therapy for a measured methanol concentration if the patient has compatible exposure plus acidosis, visual findings, or an increased osmolar gap. [16][22]" ], "subsections": [], "table": { "caption": "Alcohol dehydrogenase inhibition options for methanol toxicity. [15][16][24]", "columns": [ "Therapy", "Regimen or target", "Operational considerations" ], "rows": [ [ "Fomepizole", "15 mg/kg IV once; at 12 hours, 10 mg/kg IV every 12 hours for four doses; then 15 mg/kg IV every 12 hours while indicated. [16]", "FDA-approved; lower toxicity and simpler administration than ethanol, but acquisition cost can limit use. [10][16][24]" ], [ "Ethanol", "Target blood ethanol 100-150 mg/dL; cited IV loading dose 600-800 mg/kg. [15]", "Maintenance varies by alcohol-use status and increases during hemodialysis; requires concentration-guided adjustment. [15]" ], [ "IV sodium bicarbonate", "Use for significant acidosis or ophthalmologic abnormalities. [22]", "Corrects acidemia while antidote therapy prevents further formate generation. [22]" ] ] } }, { "id": "hemodialysis-and-monitoring", "eyebrow": "Extracorporeal Treatment", "heading": "Select hemodialysis for severe toxicity and stop only after metabolic control", "intro": "Dialysis removes methanol and toxic metabolites while correcting acid-base derangement.", "paragraphs": [ "Use intermittent hemodialysis as an adjunct to alcohol dehydrogenase blockade for severe acidosis, renal dysfunction, or clinically significant toxicity. Hemodialysis removes parent compounds and metabolites and is a key escalation treatment when acid-base derangements or organ toxicity are substantial. [5][16]", "A serum methanol concentration above 50 mg/dL has historically been used as a hemodialysis threshold; one cited guideline summary recommends dialysis above 15.6 mmol/L (50 mg/dL) until the concentration is below 6.25 mmol/L. However, more recent guidance summarized in the literature does not require dialysis solely because the level exceeds 50 mg/dL if the patient is receiving fomepizole or ethanol, remains asymptomatic, has normal arterial pH, and has no other dialysis indication. [9][14]", "Continue serial clinical and metabolic assessment during antidote therapy and dialysis: visual and neurologic status, pH, bicarbonate, anion gap, osmolar gap, and quantitative methanol when available. Persistent or worsening acidosis, new visual dysfunction, coma, seizures, or renal dysfunction should be managed as treatment failure requiring urgent extracorporeal escalation or continuation. [1][5][16][22]", "Admit patients receiving fomepizole, ethanol infusion, or hemodialysis to an ICU-level setting. Observe for delayed organ injury and maintain a low threshold for repeat renal and metabolic testing when the presentation could instead represent ethylene glycol exposure, in which renal effects often develop 24 to 72 hours after ingestion. [16]" ], "bullets": [ "Increase ethanol maintenance dosing during hemodialysis if ethanol is the selected antidote. [15]", "Do not interpret a declining osmolar gap during dialysis or antidote treatment as sufficient evidence of recovery without confirming correction of acidemia and clinical stabilization. [5][11]", "Perform an ophthalmologic reassessment after stabilization when visual symptoms occurred, because optic nerve dysfunction can persist despite treatment. [6]" ], "subsections": [], "table": { "caption": "Practical hemodialysis decision framework for methanol toxicity. [9][14][16][22]", "columns": [ "Dialysis trigger", "Rationale", "Management alongside dialysis" ], "rows": [ [ "Severe metabolic acidosis", "Dialysis corrects acid-base derangement and removes methanol and metabolites. [5][16]", "Continue alcohol dehydrogenase blockade and IV sodium bicarbonate. [22]" ], [ "Renal dysfunction", "Renal dysfunction is a stated indication for hemodialysis in severe toxic alcohol poisoning. [16]", "Continue antidote therapy and monitor metabolic indices serially. [5][16]" ], [ "Methanol concentration >50 mg/dL", "Traditional threshold for hemodialysis; one protocol continues until <6.25 mmol/L. [14]", "Individualize if asymptomatic with normal arterial pH while receiving fomepizole or ethanol and without another dialysis indication. [9]" ], [ "Visual, neurologic, or otherwise significant toxicity", "These findings indicate clinically consequential formate toxicity. [1][22]", "Urgently combine antidote, bicarbonate for acidosis, and dialysis assessment. [22]" ] ] } }, { "id": "exposure-prevention", "eyebrow": "Exposure Recognition", "heading": "Identify contaminated products and prevent further exposure", "intro": "The exposure source can clarify the differential and identify other at-risk individuals.", "paragraphs": [ "Treat ingestion of hand sanitizer labeled as ethanol but potentially contaminated with methanol as a toxic alcohol exposure. FDA has identified products testing positive for methanol despite ethanol labeling; methanol is not an acceptable ingredient in drug products, and substantial exposure can cause blindness, seizures, coma, permanent neurologic damage, or death. [1]", "Ask whether multiple persons consumed the same alcohol product or whether a household, workplace, or shelter shares the implicated product. Methanol outbreaks have occurred after contaminated or adulterated alcoholic beverages, and early source identification can direct evaluation of additional exposed persons before they develop delayed acidosis or visual toxicity. [6][22]", "Remove the suspected product from further use and preserve the container for public health or toxicologic identification when feasible. Dermal absorption has been reported, but children who ingest sanitizer and adults who consume it as an ethanol substitute are at particularly high risk for life-threatening poisoning. [1][22]" ], "bullets": [], "subsections": [], "table": { "caption": "Exposure clues that alter methanol-risk assessment. [1][6][22]", "columns": [ "Exposure clue", "Risk implication", "Next step" ], "rows": [ [ "Ingested hand sanitizer or unlabeled alcohol product", "Products labeled as ethanol have tested positive for methanol contamination. [1]", "Treat compatible illness as possible methanol poisoning and retain the product container. [1][16]" ], [ "Shared illicit or contaminated beverage", "May indicate cluster exposure and outbreak-associated poisoning. [6]", "Identify and urgently evaluate co-exposed persons with blood and urine testing as indicated. [16]" ], [ "Cleaning product, solvent, or antifreeze-related product", "Methanol-containing household and industrial products are recognized sources. [6]", "Obtain product identification while starting treatment based on clinical risk. [16][22]" ] ] } } ], "faq": [ { "question": "Can methanol toxicity be excluded by a normal osmolar gap?", "answer": "No. The osmolar gap may fall as methanol is metabolized, while formate accumulation produces high-anion-gap acidosis; severe cases may not show both classic gaps. Continue evaluation and treatment when exposure history, acidosis, or visual toxicity is compatible. [11][17][22]" }, { "question": "Is a methanol level above 50 mg/dL an automatic indication for hemodialysis?", "answer": "It is a traditional dialysis threshold, but antidote-treated patients who are asymptomatic with normal arterial pH and no other dialysis indication may not require dialysis solely for a level above 50 mg/dL. Severe acidosis, renal dysfunction, or clinical toxicity remain strong indications. 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IRIS", "detail": "iris.who.int", "url": "https://iris.who.int/server/api/core/bitstreams/8931023a-47fb-4f29-9a01-04e974abb9e6/content", "authors": "iris.who.int", "host": "iris.who.int" } ], "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "FDA updates on hand sanitizers consumers should not use | FDA", "detail": "www.fda.gov", "url": "https://www.fda.gov/drugs/drug-alerts-and-statements/fda-updates-hand-sanitizers-consumers-should-not-use", "authors": "www.fda.gov", "host": "www.fda.gov", "snippet": "Consumers who have been exposed to hand sanitizer containing methanol and are experiencing symptoms should seek immediate treatment for potential reversal of toxic effects of methanol poisoning. Substantial methanol exposure can result in nausea, vomiting, headache, blurred vision, permanent blindne", "score": 0.23033102 }, { "number": 2, "title": "118 Readers' Comments - The New England Journal of Medicine", "detail": "www.nejm.org", "url": "https://www.nejm.org/cms/asset/5540603a-d6d0-4c2f-8d49-6bf86034e7a0/assetFile/NEJMra1215672_discussion_1.html", "authors": "www.nejm.org", "host": "www.nejm.org", "snippet": "His serum osmolar gap and aniongap acidosis are favouring ethylen glycol or methanol poisoning The high lactic acid may be found as misinterpretation of lab", "score": 0.46949652 }, { "number": 3, "title": "Fomepizole for the Treatment of Methanol Poisoning", "detail": "www.nejm.org", "url": "https://www.nejm.org/doi/full/10.1056/NEJM200102083440605", "authors": "www.nejm.org", "host": "www.nejm.org", "snippet": "Methanol poisoning may result in metabolic acidosis, blindness, and death. The inhibition of alcohol dehydrogenase is fundamental to the", "score": 0.2419149 }, { "number": 4, "title": "Fomepizole for the Treatment of Ethylene Glycol Poisoning", "detail": "www.nejm.org", "url": "https://www.nejm.org/doi/pdf/10.1056/NEJM199903183401102", "authors": "www.nejm.org", "host": "www.nejm.org", "snippet": "The standard treatment is inhibition of alco- hol dehydrogenase with ethanol, given in intoxicat- ing doses, and adjunctive hemodialysis. We", "score": 0.5550741 }, { "number": 5, "title": "Toxic Alcohol Poisoning and Metabolic Acidosis | Toxicology - Nature", "detail": "www.nature.com", "url": "https://www.nature.com/nature-index/topics/l4/toxic-alcohol-poisoning-and-metabolic-acidosis", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "combining suspicion based on history, the presence of an increased osmolar gap and anion gap, and specific laboratory measurements. Management strategies centre on inhibition of alcohol dehydrogenase activity through antidotes such as fomepizole or ethanol, correction of acid–base derangements, and ", "score": 0.45522344 }, { "number": 6, "title": "Methanol toxicity; characteristics, ophthalmological sequelae and recommended treatment | Eye", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41433-025-03628-1", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Methanol, CH3OH, is a form of alcohol present in anti-freeze, cleaning products, and sometimes in illicit alcoholic beverages . There have been recent reported outbreaks in Iran , Kenya , and Laos, the latter totalling 6 in November 2024 (ref. ). These outbreaks may be because of an increased conten", "score": 0.5104727 }, { "number": 7, "title": "Treatment of Methanol Poisoning With Intravenous 4-Methylpyrazole - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S019606449770060X", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "### Med Toxicol\n\n## Cited by (62)\n\n### Fomepizole for the treatment of methanol poisoning\n\n### Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: A systematic review and consensus statement\n\n### Toxic alcohol ingestions: Clinical features, Diagno", "score": 0.73642004 }, { "number": 8, "title": "Methanol Half-Life During Ethanol Administration: Implications for Management of Methanol Poisoning - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0196064495701524", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "### Toxic alcohol ingestions: Clinical features, Diagnosis, and management\n\n### American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning\n\n### Treatment of acute methanol poisoning with fomepizole\n\n## Recommended articles\n\n### Danish Drowning Formula for iden", "score": 0.72184175 }, { "number": 9, "title": "Ethylene Glycol Elimination Kinetics and Outcomes in Patients Managed Without Hemodialysis - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0196064411018841", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "### Ann Emerg Med\n\n### Chart reviews in emergency medicine research: what are the methods?\n\n### Ann Emerg Med\n\n### 2008 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 26th annual report\n\n### Clin Toxicol\n\n### Fomepizole for ethylene glycol an", "score": 0.6894943 }, { "number": 10, "title": "The management of severe toxic alcohol ingestions at a tertiary care center after the introduction of fomepizole - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0735675707000447", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "### Toxicol Lett\n\n### Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management\n\n### Ann Emerg Med\n\n### 2003 annual report of the American Association of Poison Control Centers toxic exposure surveillance system\n\n### Am J Emerg Med\n\n### Methanol and ethylene glycol poi", "score": 0.68344116 }, { "number": 11, "title": "Increased Serum Formate in the Diagnosis of Methanol Poisoning", "detail": "academic.oup.com", "url": "https://academic.oup.com/jat/article-pdf/29/6/586/2462209/29-6-586.pdf", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "Methanol increases the osmolal gap in serum and its metabolite formate increases the anion gap. Anion gap was increased in 11 of 11, and osmolal gap in 11", "score": 0.776708 }, { "number": 12, "title": "Laboratory Recognition and Testing in Acid-Base Disorders", "detail": "academic.oup.com", "url": "https://academic.oup.com/labmed/article-pdf/30/12/776/24957270/labmed30-0776.pdf", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "Both methanol and. Determination of anion gap and serum bicarbonate is an adequate screen for most acid- base disorders, blood gases can be performed on venous", "score": 0.46920466 }, { "number": 13, "title": "Excess serum osmolality gap after ingestion of methanol | Clinical ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/clinchem/article-abstract/36/11/2004/5648803", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "We speculate that one or more metabolites with osmotic activity are formed in cases of methanol intoxication where no ethanol has also been consumed. The", "score": 0.40471974 }, { "number": 14, "title": "Prediction and validation of hemodialysis duration in acute methanol ...", "detail": "www.kidney-international.org", "url": "https://www.kidney-international.org/article/S0085-2538(15)61000-6/fulltext", "authors": "www.kidney-international.org", "host": "www.kidney-international.org", "snippet": "Current guidelines suggest instituting HD when the methanol concentration is >15.6mmol/l (50mg/dl) until concentrations are inferior to 6.25mmol", "score": 0.6211049 }, { "number": 15, "title": "[PDF] Ethylene/Propylene Glycol Toxicity - CDC Stacks", "detail": "stacks.cdc.gov", "url": "https://stacks.cdc.gov/view/cdc/7639/cdc_7639_DS1.pdf", "authors": "stacks.cdc.gov", "host": "stacks.cdc.gov", "snippet": "Table 4. Intravenous administration of ethanol in ethylene glycol and methanol poisoning Goal of ethanol therapy: Maintain blood ethanol level between 100 and 150 mg/dL Loading dose mg/kg mL of 10% ethanol/kg 600 to 800 7.6 to 10 Maintenance dose mg/kg/hr mL of 10% ethanol/kg/hr Chronic alcoholic 15", "score": 0.46599558 }, { "number": 16, "title": "Medical Management Guidelines for Ethylene Glycol - cdc.gov.", "detail": "wwwn.cdc.gov", "url": "https://wwwn.cdc.gov/Tsp/MMG/MMGDetails.aspx?mmgid=82&toxid=21", "authors": "wwwn.cdc.gov", "host": "wwwn.cdc.gov", "snippet": "In severe poisoning by ingestion,\nprompt administration of ethanol or another blocking agent\n(e.g., 4-methylpryrazole) prevents further metabolism of\nethylene glycol. Rapid treatment with a blocking agent is\nvery important; do not wait for symptoms to appear before\ntreatment. Time elapsed between in", "score": 0.43828082 }, { "number": 17, "title": "ATYPICAL PRESENTATION OF SEVERE METHANOL POISONING ...", "detail": "journal.chestnet.org", "url": "https://journal.chestnet.org/article/S0012-3692(25)02758-8/fulltext", "authors": "journal.chestnet.org", "host": "journal.chestnet.org", "snippet": "Methanol poisoning often presents with increased serum osmolar gap and a high anion gap, but these findings may not always be present.", "score": 0.70823324 }, { "number": 18, "title": "A Case of Methanol Poisoning - CHEST Journal", "detail": "journal.chestnet.org", "url": "https://journal.chestnet.org/article/S0012-3692(16)55231-3/pdf", "authors": "journal.chestnet.org", "host": "journal.chestnet.org", "snippet": "Ethanol level was less than 10 mg/dL. His calculated anion gap was 13, ABG pH 7.27, and calculated serum osmolality was. 295, indicating anion", "score": 0.6688159 }, { "number": 19, "title": "Vomiting, Abdominal Pain, and Visual Disturbances in a 31-Year ...", "detail": "journal.chestnet.org", "url": "https://journal.chestnet.org/article/S0012-3692(16)38334-9/fulltext", "authors": "journal.chestnet.org", "host": "journal.chestnet.org", "snippet": "Methanol intoxication should be suspected in a patient with nausea, vomiting, abdominal pain, visual changes, and a combined anion and osmolal gap.", "score": 0.61972505 }, { "number": 20, "title": "Adult Toxicology in Critical Carea - CHEST Journal", "detail": "journal.chestnet.org", "url": "https://journal.chestnet.org/article/S0012-3692(16)34761-4/fulltext", "authors": "journal.chestnet.org", "host": "journal.chestnet.org", "snippet": "Methanol causes an initial period of headache, inebriation, dizziness, ataxia, and confusion. the anion gap elevates and visual symptoms become more pronounced.", "score": 0.5874941 }, { "number": 21, "title": "Case 345: Methanol Poisoning | Radiology - RSNA Journals", "detail": "pubs.rsna.org", "url": "https://pubs.rsna.org/doi/10.1148/radiol.250800", "authors": "pubs.rsna.org", "host": "pubs.rsna.org", "snippet": "Vital signs showed a normal heart rate and blood pressure, with oxygen saturation measured at 80%. Arterial blood gas analysis revealed a pH of 6.86", "score": 0.55912215 }, { "number": 22, "title": "American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning - PubMed", "detail": "www.ncbi.nlm.nih.gov", "url": "http://www.ncbi.nlm.nih.gov/pubmed/12216995", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Title: American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning - PubMed\nAn official website of the United States government. Federal government websites often end in .gov or .mil. official website and that any information you provide is encrypted. ## Save c", "score": 0.83452857 }, { "number": 23, "title": "[PDF] the national protocol for treatment of substance use disorders in ...", "detail": "www.afro.who.int", "url": "https://www.afro.who.int/sites/default/files/2017-09/The%20National%20Protocol%20for%20treatments%2014%2007%202017.pdf", "authors": "www.afro.who.int", "host": "www.afro.who.int", "snippet": "Unlike ethanol, fomepizole is not commonly associated with adverse effects such as CNS depression, hypoglycemia, hypothermia and agitation.The dosing regimen of fomepizole does not require the frequent monitoring and subsequent adjustment of therapy that are necessary with ethanol treatment.The main", "score": 0.8124067 }, { "number": 24, "title": "[PDF] The Selection and Use of Essential Medicines - IRIS", "detail": "iris.who.int", "url": "https://iris.who.int/server/api/core/bitstreams/8931023a-47fb-4f29-9a01-04e974abb9e6/content", "authors": "iris.who.int", "host": "iris.who.int", "snippet": "Prospective observational studies, clinical trials and retrospective case reviews have demonstrated that fomepizole improves outcomes by improving renal function, preventing visual impairment associated with methanol poisoning, and preventing metabolic acidosis (105, 106). In a retrospective case se", "score": 0.7393665 } ], "publishedAt": "2026-09-16T00:06:06.167379+00:00", "updatedAt": "2026-09-16T00:06:06.167379+00:00", "readingMinutes": 7, "slug": "methanol-toxicity" }