{
  "schemaVersion": 2,
  "eyebrow": "Endocrinology",
  "title": "Klinefelter Syndrome",
  "summary": "Confirm suspected Klinefelter syndrome with chromosome analysis, distinguish primary testicular failure from other hypogonadal states, address fertility before testosterone when relevant, and longitudinally manage hypogonadism alongside metabolic, bone, cardiovascular, reproductive, and psychosocial comorbidity.",
  "seoDescription": "Physician guide to diagnosing and managing Klinefelter syndrome, including hormonal evaluation, chromosome testing, fertility planning, and comorbidity surveillance.",
  "clinicalQuestion": "How should physicians confirm, stage, and manage Klinefelter syndrome across endocrine, fertility, and multisystem care?",
  "specialty": "Endocrinology",
  "audience": "U.S. physicians and medical trainees",
  "tags": [
    "Klinefelter syndrome",
    "47,XXY",
    "primary hypogonadism",
    "azoospermia",
    "testosterone replacement",
    "micro-TESE",
    "male infertility"
  ],
  "keyTakeaways": [
    "Order peripheral-blood karyotype analysis to confirm suspected Klinefelter syndrome; small testes with low testosterone and elevated LH and FSH identifies the typical hypergonadotropic testicular-failure pattern. [7][13]",
    "In men evaluated for infertility, obtain karyotype analysis for azoospermia or sperm concentration below 10 million/mL; Klinefelter syndrome is disproportionately represented among azoospermic men. [24]",
    "Establish reproductive goals before testosterone therapy when TESE is contemplated, because testosterone may suppress spermatogenesis and guidelines suggest not initiating it before planned TESE. [19]",
    "For azoospermic patients pursuing biologic paternity, refer to an experienced reproductive urologist for TESE or micro-TESE; sperm can be recovered in up to 50% of cases, with higher likelihood in 46,XY/47,XXY mosaicism. [24]",
    "Treat Klinefelter syndrome as a multisystem condition: hypogonadism, infertility, metabolic syndrome, cardiovascular disease, diabetes, osteoporosis, neuropsychological burden, and reduced quality of life warrant longitudinal surveillance. [16]"
  ],
  "sections": [
    {
      "id": "when-to-suspect-and-confirm",
      "eyebrow": "Diagnosis",
      "heading": "When to suspect and confirm Klinefelter syndrome",
      "intro": "Use phenotype and gonadal testing to trigger chromosome analysis rather than relying on appearance alone.",
      "paragraphs": [
        "Test for Klinefelter syndrome in a patient with infertility, very small testes, gynecomastia, tall stature with relatively long limbs, reduced androgenic hair distribution, pubertal failure or incomplete virilization, or learning and social difficulties. Clinical phenotype is variable; in a cohort referred for suspected disease, patients with confirmed Klinefelter syndrome were taller, had smaller testes, and had higher LH and FSH values than patients with a 46,XY karyotype, while general clinical features alone did not reliably discriminate the groups. [13][14]",
        "Obtain morning total testosterone, LH, and FSH when gonadal failure is suspected. The characteristic pattern is primary testicular failure: low testosterone with elevated LH and FSH; seminiferous dysfunction may be prominent even when total testosterone remains in the low-normal range. Elevated gonadotropins with small testes supports testicular rather than hypothalamic-pituitary disease, but chromosome analysis is required for definitive diagnosis. [7][12][13]",
        "Confirm the diagnosis with peripheral-blood chromosome analysis demonstrating 47,XXY or a sex-chromosome mosaic pattern such as 46,XY/47,XXY. The usual nonmosaic complement is 47,XXY; mosaicism matters clinically because sperm production is more often observed in 46,XY/47,XXY than in nonmosaic disease. [10][24]"
      ],
      "bullets": [
        "Do not use a normal or low-normal total testosterone concentration to exclude Klinefelter syndrome; approximately one third of affected patients may have total testosterone in the low-normal range. [12]",
        "In azoospermia or oligozoospermia with sperm concentration below 10 million/mL, obtain karyotype analysis as part of genetic evaluation. [24]",
        "If the endocrine profile instead shows low or inappropriately normal LH and FSH with low testosterone, evaluate for secondary hypogonadism rather than attributing the finding to Klinefelter syndrome. [1]"
      ],
      "subsections": [],
      "table": {
        "caption": "Practical diagnostic branches in suspected Klinefelter syndrome. [1][7][12][13][24]",
        "columns": [
          "Clinical or laboratory finding",
          "Interpretation",
          "Next action"
        ],
        "rows": [
          [
            "Small testes, low testosterone, elevated LH and FSH",
            "Hypergonadotropic hypogonadism consistent with primary testicular failure; Klinefelter syndrome is a key cause. [7][12][13]",
            "Order peripheral-blood karyotype analysis. [13]"
          ],
          [
            "Low testosterone with low or inappropriately normal LH and FSH",
            "Secondary hypogonadism reflects insufficient hypothalamic or pituitary gonadotropin production rather than the typical Klinefelter pattern. [1]",
            "Evaluate hypothalamic-pituitary causes rather than assuming sex-chromosome aneuploidy. [1]"
          ],
          [
            "Azoospermia or sperm concentration <10 million/mL",
            "Chromosomal abnormalities are sufficiently prevalent to justify karyotype analysis; Klinefelter syndrome accounts for a substantial subset of azoospermia. [24]",
            "Perform karyotype analysis and refer for male-infertility evaluation. [24]"
          ],
          [
            "Confirmed 46,XY/47,XXY mosaicism",
            "Mosaicism is associated with more frequent residual germ-cell and sperm production than nonmosaic Klinefelter syndrome. [24]",
            "Discuss semen testing and fertility-directed management early. [24]"
          ]
        ]
      }
    },
    {
      "id": "initial-staging",
      "eyebrow": "Initial assessment",
      "heading": "Stage endocrine, reproductive, and multisystem consequences at diagnosis",
      "intro": "The first visit should establish gonadal function, fertility priorities, and high-impact comorbidity domains.",
      "paragraphs": [
        "After cytogenetic confirmation, document symptoms and biochemical severity of androgen deficiency with testosterone, LH, and FSH, and perform a genital examination that includes testicular size and assessment for gynecomastia. Testicular failure may evolve through puberty: inhibin B can be normal before puberty and then decline during late puberty, consistent with progressive seminiferous failure around gonadarche. [12][14]",
        "Ask specifically about current and future biologic paternity before prescribing testosterone. Obtain semen analysis when feasible because sperm production is variable and is more frequently observed with 46,XY/47,XXY mosaicism. Azoospermia does not end fertility evaluation: testicular sperm retrieval remains an option for selected patients. [24]",
        "Screen deliberately for metabolic, cardiovascular, diabetic, skeletal, reproductive, and psychological comorbidity rather than limiting follow-up to serum testosterone. Klinefelter syndrome is associated with hypogonadism, infertility, metabolic syndrome, cardiovascular disease, diabetes, osteoporosis, increased mortality risk, psychological burden, and reduced health-related quality of life. [16]"
      ],
      "bullets": [
        "Include developmental, educational, executive-function, social, mood, and quality-of-life history; verbal and social difficulties may be part of the phenotype and influence adherence, fertility counseling, and transition planning. [14][16]",
        "Assess pubertal progression in adolescents because endocrine replacement timing and dose require individualization as testicular failure emerges. [14]",
        "Coordinate endocrine, reproductive-urology, primary-care, and mental-health care according to the dominant active problem rather than waiting for infertility or symptomatic hypogonadism to emerge. [16]"
      ],
      "subsections": [],
      "table": {
        "caption": "Baseline domains that change management in confirmed Klinefelter syndrome. [14][16][24]",
        "columns": [
          "Domain",
          "Assessment",
          "Management consequence"
        ],
        "rows": [
          [
            "Androgen status",
            "Testosterone with LH and FSH; genital examination including testicular size. [7][12][13]",
            "Confirms severity of primary testicular failure and informs endocrine treatment planning. [7][12]"
          ],
          [
            "Fertility",
            "Reproductive goals, semen analysis when feasible, and mosaic status. [24]",
            "Determine whether reproductive-urology referral and TESE or micro-TESE counseling should precede testosterone. [19][24]"
          ],
          [
            "Metabolic and cardiovascular health",
            "Evaluate for metabolic syndrome, diabetes, and cardiovascular disease. [16]",
            "Address modifiable cardiometabolic disease concurrently with endocrine management. [16]"
          ],
          [
            "Bone health",
            "Assess osteoporosis risk. [16]",
            "Incorporate skeletal risk into long-term hypogonadism management. [16]"
          ],
          [
            "Psychological and neurocognitive health",
            "Assess psychological burden, social function, and health-related quality of life. [14][16]",
            "Arrange targeted behavioral-health, educational, or neuropsychological support when impairment affects function. [16]"
          ]
        ]
      }
    },
    {
      "id": "fertility-before-testosterone",
      "eyebrow": "Reproductive care",
      "heading": "Address fertility before testosterone when biologic paternity is a goal",
      "intro": "The sequencing decision is whether to pursue sperm retrieval before androgen replacement.",
      "paragraphs": [
        "Refer azoospermic men with Klinefelter syndrome who desire biologic paternity to a reproductive urologist experienced in TESE or micro-TESE. Testicular sperm can be recovered in up to 50% of azoospermic patients, and residual germ cells or sperm production are more common in 46,XY/47,XXY mosaicism. [24]",
        "Avoid starting testosterone replacement when TESE is planned, because exogenous testosterone can suppress spermatogenesis; the European Academy of Andrology guideline suggests against beginning testosterone before planned TESE. This is a sequencing issue, not a reason to withhold fertility counseling until androgen-deficiency symptoms become severe. [19]",
        "Do not routinely offer surgical fertility preservation to children with Klinefelter syndrome. Evidence summarized for patients younger than 16 years shows lower testicular sperm extraction retrieval rates than in adolescents and adults aged 16 to 30 years; germ-cell retrieval is particularly low before age 15. [20]"
      ],
      "bullets": [
        "Counsel that age is not the sole determinant of retrieval success: studies in patients aged 15 to 33 years have reported no clear age-associated difference in successful TESE in several cohorts. [20]",
        "If sperm are present in the ejaculate, prioritize conventional sperm cryopreservation over invasive retrieval. Residual sperm production is variable and cannot be inferred solely from the lymphocyte karyotype. [10][24]",
        "For an adolescent considering retrieval, individualize counseling with pediatric endocrinology and reproductive urology rather than adopting routine prepubertal TESE. [20]"
      ],
      "subsections": [],
      "table": {
        "caption": "Fertility decision points in Klinefelter syndrome. [19][20][24]",
        "columns": [
          "Situation",
          "Action",
          "Key tradeoff"
        ],
        "rows": [
          [
            "Azoospermic adult seeking biologic paternity",
            "Refer for TESE or micro-TESE evaluation. [24]",
            "Sperm recovery is possible in up to 50% of cases, but not assured. [24]"
          ],
          [
            "TESE planned and testosterone not yet started",
            "Defer testosterone replacement until reproductive-urology planning is completed. [19]",
            "Testosterone may suppress spermatogenesis and compromise retrieval planning. [19]"
          ],
          [
            "46,XY/47,XXY mosaicism",
            "Obtain semen testing and provide early fertility counseling. [24]",
            "Residual sperm production is more frequent than in nonmosaic disease but remains variable. [24]"
          ],
          [
            "Child or early adolescent",
            "Do not routinely offer fertility preservation before age 16; reassess as pubertal development and family goals evolve. [20]",
            "Retrieval rates are low in younger patients, particularly before age 15. [20]"
          ]
        ]
      }
    },
    {
      "id": "testosterone-management",
      "eyebrow": "Endocrine treatment",
      "heading": "Use testosterone replacement for established hypogonadism after fertility planning",
      "intro": "Replacement therapy addresses androgen deficiency but does not substitute for fertility-directed care or comorbidity surveillance.",
      "paragraphs": [
        "For confirmed Klinefelter syndrome with clinically significant androgen deficiency, testosterone replacement is the central endocrine treatment and is used from puberty to induce and maintain male secondary sexual characteristics. Because the severity and timing of progressive testicular failure vary, individualize initiation and dose rather than applying a uniform age-based regimen. [9][14]",
        "Before initiating testosterone, resolve whether TESE is planned. If fertility treatment is not imminent, endocrine treatment should be integrated with monitoring of metabolic, cardiovascular, bone, reproductive, and psychological domains rather than judged only by changes in testosterone concentration or sexual characteristics. [16][19]",
        "Do not presume that testosterone corrects every Klinefelter-associated risk. Published management reviews identify disease burden across metabolic, cardiovascular, thrombotic, skeletal, reproductive, neurocognitive, and quality-of-life domains; each requires condition-specific assessment and treatment. [16][18]"
      ],
      "bullets": [
        "In adolescents, use pubertal progression and the evolving pattern of testicular failure to individualize endocrine management. [14]",
        "In patients whose primary goal is fertility, prioritize semen assessment and reproductive-urology planning before exogenous testosterone exposure. [19][24]",
        "For testosterone products, follow the selected product's FDA-approved labeling for route-specific administration and safety monitoring. [1]"
      ],
      "subsections": [],
      "table": null
    },
    {
      "id": "longitudinal-care",
      "eyebrow": "Follow-up",
      "heading": "Build longitudinal care around preventable morbidity and functional outcomes",
      "intro": "Follow-up should be proactive because important complications extend beyond gonadal failure.",
      "paragraphs": [
        "At longitudinal visits, reassess cardiometabolic disease, diabetes risk, cardiovascular disease, bone health, reproductive goals, and quality of life. These domains are repeatedly identified as common comorbidities in Klinefelter syndrome and should remain active problem-list items even when androgen symptoms are controlled. [16]",
        "Revisit fertility goals before changing endocrine treatment or when a patient transitions from adolescence to adulthood. The decision to pursue TESE or micro-TESE is preference-sensitive, depends on azoospermia and local procedural expertise, and is particularly relevant before initiating or resuming testosterone therapy. [19][24]",
        "Screen for psychological burden and functional impairment at each major life transition, including school progression, transfer to adult care, partnership, and infertility evaluation. Reduced health-related quality of life has been reported across physical, psychological, and social domains, so management should include targeted support rather than relying on endocrine correction alone. [16]"
      ],
      "bullets": [
        "Maintain coordinated follow-up with endocrinology for hypogonadism, reproductive urology for fertility options, and primary care for metabolic, cardiovascular, and skeletal risk. [16][24]",
        "Escalate developmental, educational, mental-health, or neuropsychological services when language, social competence, mood, or executive-function difficulties impair daily functioning. [14][16]",
        "Document karyotype and mosaic status prominently, because it informs reproductive counseling and avoids repeated diagnostic testing. [10][24]"
      ],
      "subsections": [],
      "table": null
    }
  ],
  "faq": [],
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      "url": "https://bestpractice.bmj.com/topics/en-us/868",
      "authors": "bestpractice.bmj.com",
      "host": "bestpractice.bmj.com",
      "snippet": "Sex chromosome DSD results from the atypical complement of sex chromosomes, and includes syndromes such as Turner syndrome (45,X with one absent sex chromosome) and Klinefelter syndrome (XXY with one additional X chromosome). Mosaicism occurs when more than one type of chromosomal arrangement is pre",
      "score": 0.16482572
    },
    {
      "number": 7,
      "title": "Klinefelter Syndrome | Congenital Defects",
      "detail": "jamanetwork.com",
      "url": "https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/207495",
      "authors": "jamanetwork.com",
      "host": "jamanetwork.com",
      "snippet": "by CM Smyth · 1998 · Cited by 481 — The presence of small testes and low serum testosterone levels with elevated FSH and LH levels is usually sufficient to make the diagnosis.",
      "score": 0.5199851
    },
    {
      "number": 8,
      "title": "Klinefelter Syndrome",
      "detail": "jamanetwork.com",
      "url": "https://jamanetwork.com/HttpHandlers/ArticlePdfHandler.ashx?journal=InteMed&pdfFileName=ira70529.pdf",
      "authors": "jamanetwork.com",
      "host": "jamanetwork.com",
      "snippet": "Plasma testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) values in healthy control subjects and patients with Klinefelter syndrome",
      "score": 0.42090955
    },
    {
      "number": 9,
      "title": "Klinefelter Syndrome Clinical Perspectives and Treatments",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/nature-index/topics/l4/klinefelter-syndrome-clinical-perspectives-and-treatments",
      "authors": "www.nature.com",
      "host": "www.nature.com",
      "snippet": "Testosterone replacement therapy remains the cornerstone of endocrine management, commencing at puberty to induce and maintain secondary sexual characteristics,",
      "score": 0.47139415
    },
    {
      "number": 10,
      "title": "Detection of low-grade mosaicism and its correlation with hormonal profile, testicular volume, and semen quality in a cohort of Egyptian Klinefelter and Klinefelter-like patients - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S1642431X19304012",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "Previous studies on mosaicism have shown contradictory results on its correlation with both serum hormone levels and the presence of spermatozoa in the ejaculate of KS, KS-like, and non-KS-like infertile patients. So, the present study was designed to detect low-grade mosaicism in the peripheral blo",
      "score": 0.7014069
    },
    {
      "number": 11,
      "title": "Klinefelter Syndrome - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S1555415507004278",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "## The Journal for Nurse Practitioners. # Men's Health Klinefelter Syndrome. Klinefelter syndrome, one of the most common male genetic disorders, has an incidence of approximately 1 in 600 males. Other statistics reports that the syndrome occurs in about 1 of every 500 to 1000 newborn males. Healthy",
      "score": 0.6304352
    },
    {
      "number": 12,
      "title": "Karyotype 47,XXY - an overview | ScienceDirect Topics",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/topics/nursing-and-health-professions/karyotype-47-xxy",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "Title: Karyotype 47,XXY - an overview | ScienceDirect Topics\nXXY refers to a chromosomal condition known as Klinefelter syndrome, which typically involves males having an additional X chromosome, resulting in a chromosome complement of XXY instead of the usual XY. Klinefelter syndrome with 47,XXY ka",
      "score": 0.6279746
    },
    {
      "number": 13,
      "title": "Clinical and Diagnostic Features of Patients With Suspected Klinefelter Syndrome - Kamischke - 2003 - Journal of Andrology - Wiley Online Library",
      "detail": "onlinelibrary.wiley.com",
      "url": "https://onlinelibrary.wiley.com/doi/full/10.1002/j.1939-4640.2003.tb02638.x",
      "authors": "onlinelibrary.wiley.com",
      "host": "onlinelibrary.wiley.com",
      "snippet": "In a cohort of 309 patients suspected of having Klinefelter syndrome, we evaluated the clinical symptoms as well as the diagnostic value of the Barr body test for screening procedures. On the basis of chromosome analysis, 85 patients (group I) were diagnosed as having Klinefelter syndrome, and 224 p",
      "score": 0.6044228
    },
    {
      "number": 14,
      "title": "Klinefelter Syndrome - an overview | ScienceDirect Topics",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/klinefelter-syndrome",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "Title: Klinefelter Syndrome - an overview | ScienceDirect Topics\nKlinefelter syndrome is defined as a rare chromosomal disorder in males characterized by a 47,XXY karyotype, which can affect verbal skills and social competence, and is often associated with tall stature and infertility. Klinefelter s",
      "score": 0.57322514
    },
    {
      "number": 15,
      "title": "Combination of Klinefelter Syndrome and Acromegaly: A Rare... : Medicine",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/md-journal/fulltext/2016/04260/combination_of_klinefelter_syndrome_and.23.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "Title: Combination of Klinefelter Syndrome and Acromegaly: A Rare... : Medicine\nAbbreviations: FSH = follicle-stimulating hormone, GH = growth hormone, IGF-1 = insulin-like growth factor 1, KS = Klinefelter syndrome, LH = luteinizing hormone, MRI = magnetic resonance imaging, SHOX = short stature ho",
      "score": 0.49846253
    },
    {
      "number": 16,
      "title": "Update on Physical, Psychological, and Quality of Life Management in Klinefelter Syndrome | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic",
      "detail": "academic.oup.com",
      "url": "https://academic.oup.com/jcem/article/110/8/e2435/8123799",
      "authors": "academic.oup.com",
      "host": "academic.oup.com",
      "snippet": "Individuals with KS are at increased risk of metabolic, cardiovascular, and reproductive comorbidities, increasing mortality risk, psychological burden, and significantly diminished health-related quality of life (HR-QoL) compared to healthy controls. We provide an updated review of the recent liter",
      "score": 0.64986813
    },
    {
      "number": 17,
      "title": "Metabolic and cardiovascular risk factors in Klinefelter syndrome - Spaziani - 2020 - American Journal of Medical Genetics Part C: Seminars in Medical Genetics - Wiley Online Library",
      "detail": "onlinelibrary.wiley.com",
      "url": "https://onlinelibrary.wiley.com/doi/10.1002/ajmg.c.31792",
      "authors": "onlinelibrary.wiley.com",
      "host": "onlinelibrary.wiley.com",
      "snippet": "# Metabolic and cardiovascular risk factors in Klinefelter syndrome. H., Fedder, J., Bennett, P., … Gravholt, C. Klinefelter's syndrome, type 2 diabetes and the metabolic syndrome: The impact of body composition. *The Journal of Clinical Endocrinology and Metabolism*, 91(4), 1254–1260. *The Journal ",
      "score": 0.54724693
    },
    {
      "number": 18,
      "title": "Morbidity in Klinefelter syndrome and the effect of testosterone treatment",
      "detail": "onlinelibrary.wiley.com",
      "url": "https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.c.31798",
      "authors": "onlinelibrary.wiley.com",
      "host": "onlinelibrary.wiley.com",
      "snippet": "Morbidity in Klinefelter syndrome and the effect of testosterone treatment - Chang - 2020 - American Journal of Medical Genetics Part C: Seminars in Medical Genetics - Wiley Online Library. Morbidity in Klinefelter syndrome and the effect of testosterone treatment. 10.1111/j.1651-2227.2011.02246.x P",
      "score": 0.53094244
    },
    {
      "number": 19,
      "title": "European academy of andrology guidelines on Klinefelter ...",
      "detail": "onlinelibrary.wiley.com",
      "url": "https://onlinelibrary.wiley.com/doi/10.1111/andr.12909",
      "authors": "onlinelibrary.wiley.com",
      "host": "onlinelibrary.wiley.com",
      "snippet": "by M Zitzmann · 2021 · Cited by 237 — We suggest against starting testosterone replacement therapy in patients with KS when a TESE is planned, due to the possible suppression of",
      "score": 0.45464227
    },
    {
      "number": 20,
      "title": "Klinefelter syndrome and fertility: sperm preservation should not be offered to children with Klinefelter syndrome | Human Reproduction | Oxford Academic",
      "detail": "academic.oup.com",
      "url": "https://academic.oup.com/humrep/article/31/9/1952/2914034",
      "authors": "academic.oup.com",
      "host": "academic.oup.com",
      "snippet": "Current evidence shows that fertility preservation should not be offered to adolescents with KS younger than 16 years because of lower retrieval rates for germ cells by testicular sperm extraction (TESE) compared with retrieval rates for adolescents and adults between 16 and 30 years. reported the p",
      "score": 0.43036336
    },
    {
      "number": 21,
      "title": "Gender- and Sexual Orientation– Based Inequities",
      "detail": "ascopubs.org",
      "url": "https://ascopubs.org/doi/10.1200/EDBK_350175",
      "authors": "ascopubs.org",
      "host": "ascopubs.org",
      "snippet": "by AB Alpert · 2022 · Cited by 54 — For example, Klinefelter syndrome (47XXY) may be associated with an ... high-quality care and are included in all aspects of oncology. Ultimately",
      "score": 0.6150191
    },
    {
      "number": 22,
      "title": "Endocrine Disorders Manifesting in the Newborn Period",
      "detail": "publications.aap.org",
      "url": "https://publications.aap.org/pediatriccare/book/348/chapter/5768596/Endocrine-Disorders-Manifesting-in-the-Newborn",
      "authors": "publications.aap.org",
      "host": "publications.aap.org",
      "snippet": "The most recent recommendations on management of children with DSD, “Consensus Statement ... 47,XXY (Klinefelter syndrome and variants). Other",
      "score": 0.586926
    },
    {
      "number": 23,
      "title": "Disorders of Sex Development (Chapter 243)",
      "detail": "publications.aap.org",
      "url": "https://publications.aap.org/pediatriccare/book/348/chapter/5779144/Disorders-of-Sex-Development-Chapter-243",
      "authors": "publications.aap.org",
      "host": "publications.aap.org",
      "snippet": "Klinefelter syndrome. 47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management .",
      "score": 0.58664185
    },
    {
      "number": 24,
      "title": "Male Infertility - EAU Guidelines on Sexual and Reproductive Health - Uroweb",
      "detail": "uroweb.org",
      "url": "https://uroweb.org/guidelines/sexual-and-reproductive-health-2022/chapter/male-infertility",
      "authors": "uroweb.org",
      "host": "uroweb.org",
      "snippet": "|  |  |  |\n --- \n| Diagnosis | Unselected patients (n = 12,945) | Azoospermic patients (n = 1,446) |\n| All | 100% | 11.2% |\n| Infertility of known (possible) cause | 42.6% | 42.6% |\n| Maldescended testes | 8.4 | 17.2 |\n| Varicocele | 14.8 | 10.9 |\n| Sperm auto-antibodies | 3.9 \n| Testicular tumour |",
      "score": 0.45188335
    }
  ],
  "publishedAt": "2026-08-24T18:04:38.949669+00:00",
  "updatedAt": "2026-08-24T18:04:38.949669+00:00",
  "readingMinutes": 6,
  "slug": "klinefelter-syndrome"
}