{ "schemaVersion": 2, "eyebrow": "Consultation-Liaison Psychiatry", "title": "Illness Anxiety Disorder", "summary": "Identify illness anxiety disorder only after a proportionate medical assessment, then replace repeated reassurance and fragmented testing with one coordinating clinician, structured cognitive-behavioral therapy, and treatment of comorbid psychiatric illness.", "seoDescription": "Point-of-care approach to illness anxiety disorder: diagnostic distinction, proportionate medical evaluation, care coordination, CBT, and medication considerations.", "clinicalQuestion": "How should physicians evaluate and manage illness anxiety disorder while avoiding missed disease and reinforcing reassurance-seeking?", "specialty": "Psychiatry", "audience": "U.S. physicians and medical trainees", "tags": [ "illness anxiety disorder", "health anxiety", "hypochondriasis", "somatic symptom disorder", "cognitive-behavioral therapy", "reassurance seeking" ], "keyTakeaways": [ "Use illness anxiety disorder rather than the deprecated term hypochondriasis; DSM-5 separated the former construct into illness anxiety disorder and somatic symptom disorder. [8][12][22]", "A normal examination and laboratory evaluation do not by themselves establish illness anxiety disorder; the actionable diagnostic signal is persistent illness preoccupation and anxiety despite an appropriate medical assessment. [22][24]", "Distinguish care-seeking from care-avoidant presentations because both can perpetuate disability, while repeated reassurance, clinician switching, and uncoordinated testing can reinforce the illness-anxiety cycle. [24]", "Prioritize structured psychotherapy, particularly CBT; SSRIs may supplement psychotherapy, but psychological treatment is often preferred and may be more effective for illness anxiety disorder. [24]" ], "sections": [ { "id": "clinical-recognition", "eyebrow": "Diagnosis", "heading": "Recognize the illness-anxiety pattern after proportionate medical assessment", "intro": "Make the diagnosis from the longitudinal pattern, not from a negative test alone.", "paragraphs": [ "Illness anxiety disorder is characterized by excessive worry about having or developing a serious undiagnosed condition, with persistent fear despite normal physical examination and laboratory findings. The diagnostic pivot is disproportionate health preoccupation, anxiety, and functional interference rather than absence of all bodily symptoms. [22]", "Elicit the behavioral phenotype at each visit: repeated requests for testing or reassurance, frequent clinician changes, disease-focused online research, avoidance of appointments, and avoidance of treatments because disease or adverse effects are feared. Care-seeking and care-avoidant forms are both described; either pattern supports a focused plan rather than reflexive escalation of testing. [23][24]", "Document functional consequences that establish clinical urgency: occupational absence, financial burden from repeated medical visits, and impaired relationships. Screen for major depressive disorder, other anxiety disorders, and personality pathology because these comorbid psychiatric conditions occur at increased frequency and may require parallel treatment. [22]" ], "bullets": [ "Use the term illness anxiety disorder when illness preoccupation is the dominant syndrome; DSM-5 replaced hypochondriasis with illness anxiety disorder and somatic symptom disorder. [8][12][22]", "Consider somatic symptom disorder when distress and maladaptive thoughts or behaviors are organized around prominent somatic symptoms rather than primarily around fear of an occult illness. [8][12][24]" ], "subsections": [], "table": { "caption": "Clinical patterns that direct the next evaluation and management step. [22][24]", "columns": [ "Pattern", "Discriminator", "Next action" ], "rows": [ [ "Illness anxiety disorder", "Persistent fear of serious disease despite appropriate normal examination and laboratory findings; preoccupation dominates. [22]", "Establish one coordinated care plan and offer CBT; assess psychiatric comorbidity. [22][24]" ], [ "Somatic symptom disorder", "The former hypochondriasis construct was divided into somatic symptom disorder and illness anxiety disorder; distinguish whether prominent somatic symptoms organize the presentation. [8][12]", "Address symptom burden and maladaptive illness-related thoughts and behaviors rather than applying the illness-anxiety label solely because tests are unrevealing. [8][12]" ], [ "Care-seeking phenotype", "Frequent medical utilization, reassurance requests, or changes in medical care. [24]", "Coordinate care to limit fragmented reassurance and unnecessary procedures. [23][24]" ], [ "Care-avoidant phenotype", "Avoids medical care because confirmation of illness or treatment adverse effects are feared. [24]", "Clarify what evaluation is medically indicated, address avoidance directly in psychotherapy, and avoid equating avoidance with absence of risk. [24]" ] ] } }, { "id": "medical-safety-and-workup", "eyebrow": "Medical Safety", "heading": "Exclude active disease without converting evaluation into reassurance therapy", "intro": "Use symptom-driven assessment and reassess when the clinical presentation changes.", "paragraphs": [ "Do not attribute a potentially acute presentation to anxiety before evaluating time-sensitive disease. For chest pain, the differential includes acute cardiopulmonary, gastrointestinal, chest-wall, toxicologic, and psychological causes, including panic disorder and anxiety; follow a chest-pain evaluation pathway rather than using a psychiatric history to truncate assessment. [6]", "After history, examination, and targeted testing support no active medical explanation for the current concern, communicate the positive formulation: the symptoms and fear are real, the immediate dangerous condition has been assessed, and the next intervention targets the illness-preoccupation cycle. Repeated normal results may not reduce anxiety and can instead become another reassurance-seeking behavior. [22][24]", "Avoid the opposite error: a diagnosis of illness anxiety disorder does not immunize a patient from new disease. Reopen the medical differential when there is a new objective examination finding, a changed symptom pattern, a new exposure or medication risk, or a syndrome-specific indication for testing; otherwise, preserve continuity with the established clinician and plan. [6][22][24]" ], "bullets": [ "For acute chest pain, retain pulmonary embolism, pneumothorax, pneumonia, acute gastrointestinal disorders, chest-wall disorders, and psychological causes in the differential; anxiety is one listed cause, not a rule-out diagnosis. [6]", "Explain in advance which symptoms or objective changes will trigger reassessment; this sets a safety net without promising open-ended serial testing. [22][24]" ], "subsections": [], "table": { "caption": "Testing strategy for medical concerns in a patient with suspected illness anxiety disorder. [6][22][24]", "columns": [ "Clinical situation", "Interpretation", "Action" ], "rows": [ [ "New potentially acute symptom syndrome", "Psychological causes coexist in the differential with cardiopulmonary, gastrointestinal, chest-wall, and toxicologic disease. [6]", "Perform condition-appropriate acute evaluation before attributing symptoms to anxiety. [6]" ], [ "Persistent illness fear after normal targeted assessment", "Persistent fear despite normal examination and laboratory testing is characteristic of illness anxiety disorder. [22]", "Name the diagnosis, shift to a behavioral treatment plan, and avoid repeating tests solely to reduce anxiety. [22][24]" ], [ "New objective or syndromically changed presentation", "Illness anxiety disorder may coexist with medical disease. [23]", "Reassess the medical differential and select testing based on the new clinical finding rather than the prior psychiatric diagnosis. [23][24]" ] ] } }, { "id": "care-structure", "eyebrow": "Management", "heading": "Use a coordinated care structure to reduce reinforcement of health anxiety", "intro": "The care relationship is part of the intervention.", "paragraphs": [ "Assign a single clinician or tightly coordinated team to integrate new symptoms, prior testing, and follow-up. This is particularly important for care-seeking patients, who may undergo extensive medical care, invasive diagnostics, and even unnecessary elective surgery when anxiety-driven utilization is not contained. [23][24]", "Replace ad hoc reassurance visits with planned follow-up focused on function, avoidance, reassurance-seeking, and engagement in treatment. During each encounter, validate distress while avoiding prolonged disease-by-disease debate; excessive reassurance and excessive focus on medication can worsen anxiety in some patients. [24]", "For care-avoidant patients, identify the specific feared consequence of evaluation—diagnostic confirmation, a procedure, or treatment effects—and make a limited, explicit plan for medically indicated assessment. The objective is neither forced reassurance nor indefinite deferral, but completion of needed care while treating avoidance. [24]" ], "bullets": [ "Coordinate psychiatric and medical care when symptom-related utilization is high or when a real chronic medical disorder coexists with health anxiety. [23][24]", "Track functional targets, such as work attendance, appointment avoidance, clinician switching, and time spent researching illness, rather than using test completion as the principal outcome. [22][23][24]" ], "subsections": [], "table": { "caption": "Behavioral patterns and clinician responses that avoid reinforcing the illness-anxiety cycle. [23][24]", "columns": [ "Observed behavior", "Clinical risk", "Response" ], "rows": [ [ "Repeated reassurance requests", "Short-lived reassurance can perpetuate health-focused monitoring and repeated utilization. [24]", "Use a consistent formulation, planned follow-up, and CBT referral rather than serial reassurance testing. [24]" ], [ "Frequent clinician changes", "Fragmented assessment increases the risk of duplicative medical care. [24]", "Consolidate records and designate a coordinating clinician. [24]" ], [ "Extensive online disease research", "Obsessive health research is described in illness anxiety disorder and can amplify preoccupation. [23]", "Include research and checking behaviors as treatment targets in CBT. [23][24]" ], [ "Avoidance of visits or treatment", "Avoidance may delay needed assessment or treatment. [24]", "Specify the minimum medically indicated evaluation and treat avoidance as a behavioral target. [24]" ] ] } }, { "id": "psychotherapy-and-medication", "eyebrow": "Definitive Treatment", "heading": "Prioritize CBT and use medication as an adjunct when indicated", "intro": "Target catastrophic interpretation, checking, reassurance seeking, and avoidance.", "paragraphs": [ "Refer for structured cognitive-behavioral therapy directed at health anxiety. CBT has established efficacy across anxiety disorders, and treatment approaches for anxiety disorders have improved prognosis in illness anxiety disorder. [3][14][23]", "Offer remote CBT when access or attendance barriers prevent in-person therapy. In a primary-care noninferiority study of untreated hypochondriasis, 12 weekly internet-CBT modules with automated therapy, therapist messaging, and outreach for incomplete modules were compared with 12 weekly face-to-face CBT sessions; both interventions reduced illness-related preoccupation and anxiety. [1]", "Use an SSRI as an adjunct when psychotherapy is unavailable, insufficient, or when comorbid anxiety or depression warrants pharmacotherapy, with medication selection and dosing guided by the treated comorbidity and current prescribing guidance. Randomized trials support SSRI efficacy in illness anxiety disorder, although psychotherapy may be more effective and is often better accepted by patients. [24]", "Do not let pharmacotherapy become a new reassurance ritual. Discuss expected benefits, adverse effects, and adherence briefly and consistently, then return attention to behavioral treatment goals; excessive medication focus may worsen health anxiety. [24]" ], "bullets": [ "Choose a CBT program that explicitly addresses illness beliefs, body monitoring, online research, reassurance seeking, and avoidance; generic supportive contact alone may leave the maintaining behaviors unchanged. [23][24]", "Consider internet-delivered CBT for patients who cannot attend in person, but assess completion because the studied program included therapist outreach when modules were not completed. [1]", "Address comorbid major depression, other anxiety disorders, and personality pathology alongside illness anxiety disorder rather than assuming health anxiety is the sole driver of impairment. [22]" ], "subsections": [], "table": { "caption": "Treatment selection for illness anxiety disorder. [1][22][24]", "columns": [ "Intervention", "Best use", "Key tradeoff" ], "rows": [ [ "Structured CBT", "First-line psychological intervention for illness preoccupation, checking, reassurance seeking, and avoidance. [23][24]", "Requires engagement with feared sensations, uncertainty, and behavior change rather than repeated diagnostic certainty. [24]" ], [ "Internet-delivered CBT", "Access barrier to face-to-face therapy; studied as 12 weekly modules with therapist messaging and follow-up for noncompletion. [1]", "Completion and therapeutic support should be monitored. [1]" ], [ "SSRI", "Adjunct when psychotherapy is unavailable or insufficient, or when comorbid anxiety or depression also requires pharmacotherapy. [24]", "May be less effective than psychotherapy for illness anxiety disorder and can become a focus of health-related worry. [24]" ], [ "Integrated medical-psychiatric care", "High utilization, clinician switching, care avoidance, or coexisting medical disease. [23][24]", "Requires communication that preserves medical safety while limiting repetitive reassurance. [24]" ] ] } }, { "id": "monitoring-and-escalation", "eyebrow": "Follow-up", "heading": "Monitor function, healthcare utilization, and comorbidity rather than reassurance alone", "intro": "A normal test result is not the primary treatment outcome.", "paragraphs": [ "At planned follow-up, assess change in illness preoccupation, checking and research behaviors, care avoidance, unscheduled contacts, clinician switching, and occupational or relationship function. Illness anxiety disorder can cause disability, work absence, financial distress, and relationship impairment; improvement in these domains is more clinically meaningful than transient relief after reassurance. [22]", "Escalate psychiatric treatment when health anxiety remains functionally disabling despite a coordinated medical plan and engagement attempts, when comorbid major depression or other anxiety disorder is prominent, or when repeated utilization exposes the patient to invasive or unnecessary procedures. [22][23][24]", "Maintain a dual-track plan: preserve a defined route for reassessing new medically meaningful symptoms while continuing CBT and coordinated care for established health anxiety. This approach avoids both diagnostic overshadowing and reinforcement of recurrent reassurance seeking. [6][22][24]" ], "bullets": [ "Review all prior evaluations before ordering repeat testing to identify duplication and to clarify what would constitute a clinically meaningful change. [23][24]", "When the patient has a medical condition, treat the medical disorder according to its own indications while separately addressing the disproportionate illness fear and health behaviors. [23][24]" ], "subsections": [], "table": { "caption": "Follow-up domains that indicate whether management is working. [22][23][24]", "columns": [ "Domain", "Improvement signal", "Escalation signal" ], "rows": [ [ "Function", "Less work absence, financial burden, and relationship disruption. [22]", "Persistent disability despite coordinated care and treatment engagement. [22][24]" ], [ "Healthcare use", "Fewer unplanned reassurance contacts, clinician changes, and duplicative procedures. [23][24]", "Ongoing extensive care use or pursuit of invasive and unnecessary interventions. [23][24]" ], [ "Avoidance", "Completion of medically indicated visits or treatments despite fear. [24]", "Continued avoidance of needed assessment or treatment. [24]" ], [ "Psychiatric comorbidity", "Improvement in coexisting depression or anxiety symptoms. [22]", "Emergent or persistent major depression, other anxiety disorders, or personality pathology affecting care. [22]" ] ] } } ], "faq": [], "references": [ { "number": 1, "title": "Internet CBT for Hypochondriasis | NEJM Clinician", "detail": "clinician.nejm.org", "url": "https://clinician.nejm.org/internet-cbt-hypochondriasis-nejm-jw.NA51635", "authors": "clinician.nejm.org", "host": "clinician.nejm.org" }, { "number": 2, "title": "A Randomized Effectiveness Trial of Cognitive-Behavioral ...", "detail": "jamanetwork.com", "url": "https://jamanetwork.com/journals/jamapsychiatry/fullarticle/208417", "authors": "jamanetwork.com", "host": "jamanetwork.com" }, { "number": 3, "title": "Anxiety disorders | Nature Reviews Disease Primers", "detail": "www.nature.com", "url": "https://www.nature.com/articles/nrdp201724", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 4, "title": "Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors | Neuropsychopharmacology", "detail": "www.nature.com", "url": "https://www.nature.com/articles/npp2017289", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 5, "title": "Anxiety and depression in emerging adults: The STAND ...", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41386-025-02174-4", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 6, "title": "2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001029", "authors": "www.ahajournals.org", "host": "www.ahajournals.org" }, { "number": 7, "title": "CBT treatment delivery formats for generalized anxiety disorder: a systematic review and network meta-analysis of randomized controlled trials | Translational Psychiatry", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41398-025-03414-3", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 8, "title": "Annual Research Review: Health anxiety in children and ...", "detail": "acamh.onlinelibrary.wiley.com", "url": "https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.13912", "authors": "acamh.onlinelibrary.wiley.com", "host": "acamh.onlinelibrary.wiley.com" }, { "number": 9, "title": "Do people with and without medical conditions respond ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0022399914004504", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 10, "title": "Health Anxiety - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/neuroscience/health-anxiety", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 11, "title": "A cohort study in routine psychiatric care", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/pii/S2214782924000733", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 12, "title": "The moderating effect of age among patients in primary care", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0887618517300348", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 13, "title": "Cost‐effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder - Apeldoorn - 2014 - Acta Psychiatrica Scandinavica - Wiley Online Library", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12169", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com" }, { "number": 14, "title": "12 Research Agenda for Anxiety Disorders - Oxford Academic", "detail": "academic.oup.com", "url": "https://academic.oup.com/book/1235/chapter/140122996", "authors": "academic.oup.com", "host": "academic.oup.com" }, { "number": 15, "title": "Management of comorbid mental and somatic disorders in ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/fampra/article/36/1/38/5233007", "authors": "academic.oup.com", "host": "academic.oup.com" }, { "number": 16, "title": "Efficacy of Cognitive Behavioral Therapy for Anxiety Disorders ...", "detail": "agsjournals.onlinelibrary.wiley.com", "url": "https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2011.03824.x", "authors": "agsjournals.onlinelibrary.wiley.com", "host": "agsjournals.onlinelibrary.wiley.com" }, { "number": 17, "title": "Clinical guideline scope", "detail": "www.nice.org.uk", "url": "https://www.nice.org.uk/guidance/cg113/documents/anxiety-partial-update-final-scope2", "authors": "www.nice.org.uk", "host": "www.nice.org.uk" }, { "number": 18, "title": "NCT06805565 | A Study of ONO-1110 in Patients With ...", "detail": "clinicaltrials.gov", "url": "https://clinicaltrials.gov/study/NCT06805565", "authors": "clinicaltrials.gov", "host": "clinicaltrials.gov" }, { "number": 19, "title": "Study Details | NCT06973577 | P3b Short-term Study of CTN in Patients With ADHD and Comorbid Anxiety | ClinicalTrials.gov", "detail": "clinicaltrials.gov", "url": "https://clinicaltrials.gov/study/NCT06973577", "authors": "clinicaltrials.gov", "host": "clinicaltrials.gov" }, { "number": 20, "title": "Study Details | NCT06701903 | Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder | ClinicalTrials.gov", "detail": "clinicaltrials.gov", "url": "https://clinicaltrials.gov/study/NCT06701903", "authors": "clinicaltrials.gov", "host": "clinicaltrials.gov" }, { "number": 21, "title": "Generalised anxiety disorder and panic disorder in adults ...", "detail": "www.nice.org.uk", "url": "https://www.nice.org.uk/Guidance/cg113", "authors": "www.nice.org.uk", "host": "www.nice.org.uk" }, { "number": 22, "title": "Illness Anxiety Disorder - StatPearls - NCBI Bookshelf", "detail": "ncbi.nlm.nih.gov", "url": "http://ncbi.nlm.nih.gov/books/NBK554399", "authors": "ncbi.nlm.nih.gov", "host": "ncbi.nlm.nih.gov" }, { "number": 23, "title": "Toward a Lifestyle Medicine Approach to Illness Anxiety Disorder (Formerly Hypochondriasis) - PMC", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146366", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov" }, { "number": 24, "title": "Severe Illness Anxiety Treated by Integrating Inpatient Psychotherapy With Medical Care and Minimizing Reassurance - PMC", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438952", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov" } ], "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "Internet CBT for Hypochondriasis | NEJM Clinician", "detail": "clinician.nejm.org", "url": "https://clinician.nejm.org/internet-cbt-hypochondriasis-nejm-jw.NA51635", "authors": "clinician.nejm.org", "host": "clinician.nejm.org", "snippet": "# Internet CBT for Hypochondriasis\n\n###### Topics\n\nIn the current era of social distancing, remote and Internet-based treatments have largely replaced in-person treatment, but is the substitution equivalent? In a Swedish randomized, noninferiority study of 204 primary care patients (mean age, 39; 70", "score": 0.26031 }, { "number": 2, "title": "A Randomized Effectiveness Trial of Cognitive-Behavioral ...", "detail": "jamanetwork.com", "url": "https://jamanetwork.com/journals/jamapsychiatry/fullarticle/208417", "authors": "jamanetwork.com", "host": "jamanetwork.com", "snippet": "by PP Roy-Byrne · 2005 · Cited by 421 — Cognitive-behavioral therapy is a modality with proven efficacy for panic disorder, is often preferred by primary care patients with anxiety, and has been", "score": 0.10725989 }, { "number": 3, "title": "Anxiety disorders | Nature Reviews Disease Primers", "detail": "www.nature.com", "url": "https://www.nature.com/articles/nrdp201724", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Google Scholar\n179. White, K. S. et al. Does maintenance CBT contribute to long-term treatment response of panic disorder with or without agoraphobia? A randomized controlled clinical trial. J. Consult. Clin. Psychol. 81, 47–57 (2013).\n\n Google Scholar\n180. Craske, M. G. et al. CBT intensity and", "score": 0.18594754 }, { "number": 4, "title": "Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors | Neuropsychopharmacology", "detail": "www.nature.com", "url": "https://www.nature.com/articles/npp2017289", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "## Author information\n\n### Authors and Affiliations\n\n1. Department of Psychiatry, University of Illinois-Chicago, Chicago, IL, USA\n\n Stephanie M Gorka, Katie L Burkhouse, Heide Klumpp, Amy E Kennedy, Kaveh Afshar, Jennifer Francis, Olusola Ajilore, Scott Mariouw, Scott Langenecker, Stewart A Shank", "score": 0.14074938 }, { "number": 5, "title": "Anxiety and depression in emerging adults: The STAND ...", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41386-025-02174-4", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Moderate effect sizes are observed for SSRIs and SNRIs for adult depression compared to placebo controls . As with anxiety disorders, very few studies specifically target young adults, and only SSRIs are FDA approved for depression in youth under 18. Individual patient characteristics have been inve", "score": 0.13158582 }, { "number": 6, "title": "2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001029", "authors": "www.ahajournals.org", "host": "www.ahajournals.org", "snippet": "Google Scholar\n\n30.\n\nCampbell KA, Madva EN, Villegas AC, et al. Non-cardiac chest pain: a review for the consultation-liaison psychiatrist. _Psychosomatics_. 2017;58:252–265.\n\nCrossref\n\nPubMed\n\nGoogle Scholar\n\n#### 4.3.3. Evaluation of Acute Chest Pain in Patients With Sickle Cell Disease\n\n1.\n\nPlatt", "score": 0.10558828 }, { "number": 7, "title": "CBT treatment delivery formats for generalized anxiety disorder: a systematic review and network meta-analysis of randomized controlled trials | Translational Psychiatry", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41398-025-03414-3", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "2019 pandemic situation, remote mental health care is encouraged . A meta-analysis comparing face-to-face with internet-based cognitive behavior therapy suggested the effect sizes of the two treatments were similar in GAD patients . [...] Article \n CAS \n PubMed \n PubMed Central \n Google Scho", "score": 0.45101276 }, { "number": 8, "title": "Annual Research Review: Health anxiety in children and ...", "detail": "acamh.onlinelibrary.wiley.com", "url": "https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.13912", "authors": "acamh.onlinelibrary.wiley.com", "host": "acamh.onlinelibrary.wiley.com", "snippet": "In the DSM-5, the diagnosis of hypochondriasis has been replaced by two new diagnostic entities: somatic symptom disorder and illness anxiety", "score": 0.6350646 }, { "number": 9, "title": "Do people with and without medical conditions respond ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0022399914004504", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "by DM LeBouthillier · 2015 · Cited by 35 — ... hypochondriasis would most likely meet criteria for the new DSM-5 diagnoses of illness anxiety disorder or complex somatic symptoms disorder [5]. Although", "score": 0.59824234 }, { "number": 10, "title": "Health Anxiety - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/neuroscience/health-anxiety", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "According to the DSM-5, diagnosis of illness anxiety disorder must include the following factors: • Preoccupation with acquiring or having a serious illness.", "score": 0.5931622 }, { "number": 11, "title": "A cohort study in routine psychiatric care", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/pii/S2214782924000733", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "by S Österman · 2024 · Cited by 9 — According to the clinic's guidelines, patients should (a) have a principal diagnosis of DSM-5 illness anxiety disorder or somatic symptom disorder with a", "score": 0.5849357 }, { "number": 12, "title": "The moderating effect of age among patients in primary care", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0887618517300348", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "by TA Fergus · 2017 · Cited by 33 — More precisely, hypochondriasis was split into two DSM-5 diagnoses: somatic symptom disorder and illness anxiety disorder (Rief & Martin, 2014). The symptom", "score": 0.53517187 }, { "number": 13, "title": "Cost‐effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder - Apeldoorn - 2014 - Acta Psychiatrica Scandinavica - Wiley Online Library", "detail": "onlinelibrary.wiley.com", "url": "https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12169", "authors": "onlinelibrary.wiley.com", "host": "onlinelibrary.wiley.com", "snippet": "# Cost-effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder. The objective of this study was to assess the cost-effectiveness of three empirically supported treatments for panic disorder with or without agoraphobia: cognitive behavioral therapy (CBT), pharmacotherapy using a ", "score": 0.22331817 }, { "number": 14, "title": "12 Research Agenda for Anxiety Disorders - Oxford Academic", "detail": "academic.oup.com", "url": "https://academic.oup.com/book/1235/chapter/140122996", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "The methodological quality, large sample sizes, and encouraging results of multiple randomized controlled trials support the efficacy of CBT protocols", "score": 0.36718005 }, { "number": 15, "title": "Management of comorbid mental and somatic disorders in ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/fampra/article/36/1/38/5233007", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "by K Maehder · 2019 · Cited by 24 — Delivery of evidence-based treatment for multiple anxiety disorders in primary care: a randomized controlled trial .", "score": 0.32389367 }, { "number": 16, "title": "Efficacy of Cognitive Behavioral Therapy for Anxiety Disorders ...", "detail": "agsjournals.onlinelibrary.wiley.com", "url": "https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2011.03824.x", "authors": "agsjournals.onlinelibrary.wiley.com", "host": "agsjournals.onlinelibrary.wiley.com", "snippet": "Meta-analyses showed that, at 0-month follow-up, CBT was significantly and modestly more effective at reducing anxiety symptoms than treatment", "score": 0.25855803 }, { "number": 17, "title": "Clinical guideline scope", "detail": "www.nice.org.uk", "url": "https://www.nice.org.uk/guidance/cg113/documents/anxiety-partial-update-final-scope2", "authors": "www.nice.org.uk", "host": "www.nice.org.uk", "snippet": "Italy, Netherlands, and Spain) reported a much lower 12-month prevalence of 4.6% for anxiety disorders as a whole. 3.2 Current practice a) GAD, along with other anxiety disorders, is most commonly treated in primary care, although some with more severe impairment are also treated in secondary care. ", "score": 0.39319915 }, { "number": 18, "title": "NCT06805565 | A Study of ONO-1110 in Patients With ...", "detail": "clinicaltrials.gov", "url": "https://clinicaltrials.gov/study/NCT06805565", "authors": "clinicaltrials.gov", "host": "clinicaltrials.gov", "snippet": "... clinical trial and complying with its requirements; Participants diagnosed with social anxiety disorder based on DSM-5-TR (Diagnostic and Statistical Manual", "score": 0.3229961 }, { "number": 19, "title": "Study Details | NCT06973577 | P3b Short-term Study of CTN in Patients With ADHD and Comorbid Anxiety | ClinicalTrials.gov", "detail": "clinicaltrials.gov", "url": "https://clinicaltrials.gov/study/NCT06973577", "authors": "clinicaltrials.gov", "host": "clinicaltrials.gov", "snippet": "6. Participants with lifetime DSM-5-TR diagnosis of neurocognitive disorder, schizophrenia or any psychotic disorder, bipolar disorder, autism spectrum disorder, or personality disorders. Participants with current diagnosis of post-traumatic stress disorder, obsessive compulsive disorder, any subs", "score": 0.30148593 }, { "number": 20, "title": "Study Details | NCT06701903 | Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder | ClinicalTrials.gov", "detail": "clinicaltrials.gov", "url": "https://clinicaltrials.gov/study/NCT06701903", "authors": "clinicaltrials.gov", "host": "clinicaltrials.gov", "snippet": "Eligibility Criteria\n\nDescription\n\nInclusion Criteria:\n\n Provide written informed consent before the initiation of any study specific procedures;\n At Screening, meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) diagnostic criteria for moderate or", "score": 0.22324194 }, { "number": 21, "title": "Generalised anxiety disorder and panic disorder in adults ...", "detail": "www.nice.org.uk", "url": "https://www.nice.org.uk/Guidance/cg113", "authors": "www.nice.org.uk", "host": "www.nice.org.uk", "snippet": "You are here:\n\n# Generalised anxiety disorder and panic disorder in adults: management\n\n## Overview\n\nThis guideline covers the care and treatment of people aged 18 and over with generalised anxiety disorder (chronic anxiety) or panic disorder (with or without agoraphobia or panic attacks). It aims t", "score": 0.17592032 }, { "number": 22, "title": "Illness Anxiety Disorder - StatPearls - NCBI Bookshelf", "detail": "ncbi.nlm.nih.gov", "url": "http://ncbi.nlm.nih.gov/books/NBK554399", "authors": "ncbi.nlm.nih.gov", "host": "ncbi.nlm.nih.gov", "snippet": "## StatPearls [Internet].\n\n# Illness Anxiety Disorder\n\nJennifer H. French; Sajid Hameed.\n\n#### Authors\n\nJennifer H. French1; Sajid Hameed2.\n\n#### Authors\n\n#### Affiliations\n\nLast Update: July 16, 2023.\n\n## Continuing Education Activity\n\nIllness anxiety disorder (previously called hypochondriasis) is", "score": 0.49758363 }, { "number": 23, "title": "Toward a Lifestyle Medicine Approach to Illness Anxiety Disorder (Formerly Hypochondriasis) - PMC", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146366", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Lifestyle medicine may be the most effective way of treating illness anxiety disorder (IAD), formerly hypochondriasis. ‘Patients with IAD [illness anxiety disorder] may not only have anxiety about health and disease in themselves but also in people around them’. Between ill health at one extreme and", "score": 0.391802 }, { "number": 24, "title": "Severe Illness Anxiety Treated by Integrating Inpatient Psychotherapy With Medical Care and Minimizing Reassurance - PMC", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438952", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Illness anxiety disorder (IAD) is characterized by excessive concern about acquiring or having serious medical illnesses that interferes with normal functioning, persisting despite normal medical workup and reassurance. Patients with IAD may seek excessive medical care or request frequent changes to", "score": 0.5215936 } ], "publishedAt": "2026-08-24T18:48:23.038796+00:00", "updatedAt": "2026-08-24T18:48:23.038796+00:00", "readingMinutes": 5, "slug": "illness-anxiety-disorder" }