{
  "schemaVersion": 2,
  "eyebrow": "Neurocritical Care",
  "title": "ICH Blood Pressure Management",
  "summary": "In acute spontaneous intracerebral hemorrhage, rapidly achieve smooth systolic blood pressure control near 140 mm Hg while avoiding overshoot hypotension, marked variability, and delays during the early hematoma-expansion window.",
  "seoDescription": "Practical acute blood pressure management for spontaneous intracerebral hemorrhage, including targets, monitoring, drug selection, and overshoot avoidance.",
  "clinicalQuestion": "How should systolic blood pressure be lowered and monitored during acute spontaneous intracerebral hemorrhage?",
  "specialty": "Neurology and Neurocritical Care",
  "audience": "U.S. physicians and medical trainees",
  "tags": [
    "intracerebral hemorrhage",
    "acute blood pressure management",
    "systolic blood pressure target",
    "nicardipine",
    "clevidipine",
    "hematoma expansion",
    "neurocritical care"
  ],
  "keyTakeaways": [
    "For acute spontaneous ICH, an SBP target near 140 mm Hg is a practical intensive-lowering target; treatment should prioritize early achievement and stable maintenance rather than episodic or highly variable control.[17][18][23]",
    "Avoid SBP overshoot below 120 mm Hg: lower achieved SBP has been associated with remote ischemic lesions, neurologic deterioration, acute kidney injury, and longer neuro-ICU stay.[21]",
    "Use a titratable intravenous infusion when sustained control is needed; nicardipine has trial-based feasibility data in ICH, and clevidipine and nicardipine have comparable target-achievement time and safety across heterogeneous hypertensive-emergency cohorts.[17][24]",
    "Patients presenting early are at meaningful risk of hematoma expansion, which occurs in up to 38% of ICH cases and is linked to early neurologic deterioration and poor outcome.[14]",
    "Frequent BP measurement is necessary during active titration; one hyperacute ICH protocol measured BP every 15 minutes for 2 hours, then hourly for 22 hours while maintaining SBP 120-160 mm Hg.[22]"
  ],
  "sections": [
    {
      "id": "initial-target-and-timing",
      "eyebrow": "First hours",
      "heading": "Set an early, smooth systolic target",
      "intro": "Treat elevated SBP as a time-sensitive hematoma-expansion modifier while preserving perfusion.",
      "paragraphs": [
        "For patients with acute spontaneous ICH and elevated SBP requiring intravenous treatment, use an SBP goal near 140 mm Hg as the operational target. Intensive BP reduction has been tested in major ICH trials, and a 140 mm Hg target is considered appropriate for acute hemorrhagic stroke; however, the outcome effects of BP lowering remain dependent on timing, achieved pressure, and treatment consistency.[1][2][17][18]",
        "Begin titratable treatment promptly after initial stabilization and diagnostic confirmation, particularly in hyperacute presentations. Hematoma expansion occurs in up to 38% of ICH cases and contributes to early neurologic deterioration; deterioration from enlarging deep hematomas may occur within the first 24 hours, including in the first several hours after onset.[6][14]",
        "Do not equate a target of 140 mm Hg with permission to drive SBP substantially below that value. An institutional shift from SBP below 160 to below 140 mm Hg, particularly when SBP was allowed below 120 mm Hg, was associated with remote cerebral ischemic lesions, in-hospital neurologic deterioration, acute kidney injury, and longer neurocritical-care stay.[21]"
      ],
      "bullets": [
        "Use continuous or very frequent noninvasive BP assessment during infusion titration; obtain an arterial line when hemodynamic instability, unreliable cuff readings, or the need for highly precise titration makes it clinically necessary.",
        "Document last-known-well or symptom-onset time, initial SBP, serial neurologic examination, and treatment start time; early presentation identifies the period in which hematoma growth prevention is most relevant.[2][6][14]",
        "If consciousness declines, new pupillary asymmetry develops, or focal deficits worsen during titration, reassess BP immediately and obtain urgent repeat neuroimaging to evaluate hematoma growth or mass effect.[6]"
      ],
      "subsections": [],
      "table": {
        "caption": "Operational BP approach during acute spontaneous ICH.[17][18][21][22]",
        "columns": [
          "Clinical situation",
          "Immediate BP action",
          "Monitoring and next step"
        ],
        "rows": [
          [
            "Elevated SBP in acute spontaneous ICH requiring IV therapy",
            "Use a titratable IV strategy aimed at SBP near 140 mm Hg.[17][18]",
            "Measure frequently during titration and maintain a stable achieved pressure rather than repeated large corrections.[13][22]"
          ],
          [
            "SBP approaches or falls below 120 mm Hg",
            "Reduce or pause antihypertensive intensity and reassess the pressure trajectory and neurologic status.[21]",
            "Evaluate for neurologic deterioration and renal injury; avoid continued overshoot below the intended treatment range.[21]"
          ],
          [
            "Neurologic decline in the first 24 hours",
            "Do not attribute decline to hypertension alone; urgently evaluate for hematoma expansion or evolving mass effect.[6][14]",
            "Repeat neurologic examination and urgent brain imaging while maintaining controlled—not hypotensive—SBP.[6][21]"
          ],
          [
            "Highly variable SBP despite treatment",
            "Replace intermittent, reactive dosing with a titratable regimen that can maintain a narrow SBP trajectory.[13][17]",
            "Review infusion delivery, measurement quality, pain or agitation, and concurrent vasoactive drugs."
          ]
        ]
      }
    },
    {
      "id": "measurement-and-monitoring",
      "eyebrow": "Titration",
      "heading": "Monitor achieved SBP and variability, not only the prescribed target",
      "intro": "The achieved BP profile determines whether treatment is controlled, delayed, or excessive.",
      "paragraphs": [
        "During the initial treatment period, use a measurement schedule capable of detecting both inadequate control and overshoot. In a hyperacute ICH cohort with baseline SBP above 180 mm Hg, protocolized IV antihypertensive treatment targeted and maintained SBP 120-160 mm Hg, with measurements every 15 minutes for the first 2 hours and every 60 minutes for the next 22 hours.[22]",
        "Track serial SBP values rather than relying on a single post-treatment measurement. BP variability after ICH has been specifically evaluated as an outcome-related exposure in INTERACT2 analyses, supporting a practical strategy of minimizing avoidable excursions through continuous titration rather than alternating untreated hypertension with bolus-induced hypotension.[13]",
        "Use a structured neurologic reassessment during active BP reduction. In the hyperacute ICH protocol, neurologic deterioration was defined as a Glasgow Coma Scale decrease of at least 2 points or NIH Stroke Scale increase of at least 4 points; such a change should trigger immediate review of BP trajectory and urgent evaluation for hematoma expansion.[22]"
      ],
      "bullets": [
        "Record the lowest SBP, time below target, and magnitude of SBP decline after each infusion adjustment; these data identify overshoot that a mean BP can conceal.[21][22]",
        "Check serum creatinine during intensive treatment, especially after low SBP excursions or in patients with baseline renal vulnerability, because acute kidney injury was associated with protocols permitting SBP below 120 mm Hg.[21]",
        "Use repeat noncontrast head CT promptly for neurologic deterioration, because hematoma enlargement is a recognized mechanism of early decline.[6][14]"
      ],
      "subsections": [],
      "table": {
        "caption": "Monitoring parameters that change immediate BP management in ICH.[6][13][21][22]",
        "columns": [
          "Parameter",
          "Actionable finding",
          "Response"
        ],
        "rows": [
          [
            "Serial SBP",
            "Large excursions around the intended target or SBP below 120 mm Hg.[13][21]",
            "Adjust infusion strategy to restore stable SBP near 140 mm Hg and prevent recurrent overshoot.[18][21]"
          ],
          [
            "Neurologic examination",
            "GCS decrease of at least 2 points or NIHSS increase of at least 4 points.[22]",
            "Urgently reassess BP, obtain repeat brain imaging, and evaluate hematoma expansion or mass effect.[6][22]"
          ],
          [
            "Renal function",
            "Acute kidney injury during intensive lowering, especially with very low achieved SBP.[21]",
            "Reassess BP intensity, volume status, concurrent nephrotoxins, and the need for continued infusion."
          ],
          [
            "Timing from onset",
            "Presentation in the first hours, when expansion-related deterioration is most relevant.[2][6][14]",
            "Prioritize rapid but controlled attainment of the SBP target.[2][23]"
          ]
        ]
      }
    },
    {
      "id": "agent-selection",
      "eyebrow": "Intravenous therapy",
      "heading": "Choose a titratable agent that delivers stable control",
      "intro": "Select the infusion around titration precision, contraindications, and local administration capability.",
      "paragraphs": [
        "Nicardipine has been used as the intravenous antihypertensive agent in ICH studies targeting SBP tiers of 170-200, 140-170, and 110-140 mm Hg, with feasibility assessed over 18-24 hours. This supports nicardipine as a practical infusion option when sustained, protocolized SBP control is required.[17]",
        "Clevidipine and nicardipine are reasonable alternatives for acute SBP control in neurocritical and hypertensive-emergency populations. A systematic review and meta-analysis including 1,378 patients found comparable time to target SBP and similar safety profiles; clevidipine may facilitate very rapid, precise short-term adjustments, whereas nicardipine may provide stable maintenance once target pressure is reached.[24]",
        "Avoid relying on intermittent treatment patterns that create repeated high-to-low BP swings. The clinical objective is not merely an isolated SBP value under 140 mm Hg but controlled early reduction followed by maintenance without hypotension or substantial variability.[13][21][23]"
      ],
      "bullets": [
        "Prefer a continuously titratable infusion when frequent adjustment is anticipated or when SBP remains substantially above goal after initial measures.[17][24]",
        "Choose clevidipine when exceptionally rapid adjustment is operationally important; choose nicardipine when stable maintenance and local familiarity favor it.[24]",
        "When using any agent, titrate against frequent measured SBP and stop escalation if SBP nears 120 mm Hg or neurologic or renal complications emerge.[21][22]"
      ],
      "subsections": [],
      "table": {
        "caption": "Evidence-supported considerations for IV infusion choice in acute ICH BP management.[17][24]",
        "columns": [
          "Agent",
          "Supported role",
          "Selection consideration"
        ],
        "rows": [
          [
            "Nicardipine",
            "Used in ICH feasibility studies across SBP target tiers, including 110-140 mm Hg, with treatment maintained for 18-24 hours.[17]",
            "Useful when a familiar, titratable infusion is needed for sustained maintenance after target attainment.[17][24]"
          ],
          [
            "Clevidipine",
            "Comparable with nicardipine for time to target SBP and safety in pooled hypertensive-emergency and neurocritical-care studies.[24]",
            "May be preferred when extremely rapid titration and precise short-term adjustments are required.[24]"
          ]
        ]
      }
    },
    {
      "id": "avoid-common-errors",
      "eyebrow": "Safety",
      "heading": "Avoid overshoot, delay, and false reassurance after target attainment",
      "intro": "The main preventable hazards are hypotension, BP lability, and missed clinical deterioration.",
      "paragraphs": [
        "Overshoot is clinically consequential. Lower-target ICH management that allowed SBP below 120 mm Hg has been associated with cerebral ischemic lesions, neurologic deterioration, acute kidney injury, and longer neuro-ICU admission; respond to a low reading by reviewing the full pressure trajectory rather than continuing protocol-driven escalation.[21]",
        "Do not assume that reaching an SBP target excludes ongoing hemorrhage progression. Early neurologic deterioration may result from hematoma growth, particularly during the first 6 hours and through the first 24 hours in deep hematomas; new decline warrants urgent repeat assessment and imaging even when SBP is controlled.[6]",
        "Use BP management as one component of acute ICH care, not as a substitute for serial neurologic examination and escalation for mass effect or surgical decision-making. In particular, catastrophic enlargement can produce rapid loss of brainstem reflexes in putaminal hemorrhage, a pattern requiring immediate emergency reassessment rather than further incremental BP adjustments alone.[6]"
      ],
      "bullets": [
        "Escalate immediately for abrupt GCS decline, new loss of pupillary reactivity, or rapidly progressive deficits; obtain urgent neuroimaging and involve the appropriate neurocritical-care and neurosurgical teams.[6]",
        "If SBP remains uncontrolled despite a properly functioning infusion, verify cuff size and measurement technique, assess agitation or pain, review all vasoactive medications, and consider invasive BP monitoring when precision is essential.",
        "After the hyperacute infusion period, continue to avoid large SBP swings; BP variability after ICH has been associated with clinical outcome analyses in INTERACT2.[13]"
      ],
      "subsections": [],
      "table": {
        "caption": "Common BP-management failure modes and immediate corrective actions.[6][13][21][22]",
        "columns": [
          "Failure mode",
          "Why it matters",
          "Corrective action"
        ],
        "rows": [
          [
            "SBP below 120 mm Hg",
            "Associated with ischemic lesions, neurologic deterioration, acute kidney injury, and longer neuro-ICU stay.[21]",
            "Decrease antihypertensive intensity, reassess neurologic status, and monitor renal function.[21]"
          ],
          [
            "Intermittent BP spikes and troughs",
            "BP variability is an outcome-relevant exposure after ICH.[13]",
            "Use a titratable approach with frequent reassessment rather than repeated reactive corrections.[13][22]"
          ],
          [
            "New neurologic deterioration despite target SBP",
            "May reflect hematoma expansion or mass effect rather than BP-treatment failure alone.[6][14]",
            "Obtain urgent repeat CT and reassess the broader ICH management plan.[6]"
          ],
          [
            "Delayed initiation in a hyperacute presentation",
            "Early hematoma growth is linked to deterioration and poor outcomes.[2][6][14]",
            "Start controlled IV treatment promptly while avoiding abrupt overcorrection.[17][21]"
          ]
        ]
      }
    }
  ],
  "faq": [],
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  "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.",
  "citations": [
    {
      "number": 1,
      "title": "Blood pressure control and clinical outcomes in acute intracerebral ...",
      "detail": "www.thelancet.com",
      "url": "https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30196-6/fulltext?dgcid=raven_jbs_etoc_email",
      "authors": "www.thelancet.com",
      "host": "www.thelancet.com",
      "snippet": "Uncertainty persists over the effects of blood pressure lowering in acute intracerebral haemorrhage. We aimed to combine individual patient-level data from",
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    {
      "number": 2,
      "title": "Degree and Timing of Intensive Blood Pressure Lowering ... - Stroke",
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      "snippet": "INTERACT2 was an international clinical trial of intensive. BP lowering in 2839 patients within 6 hours of spontaneous intracerebral hemorrhage",
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    {
      "number": 3,
      "title": "Systolic Blood Pressure After Intravenous Antihypertensive ...",
      "detail": "stroke.ahajournals.org",
      "url": "http://stroke.ahajournals.org/content/early/2013/05/23/STROKEAHA.113.001212.abstract",
      "authors": "stroke.ahajournals.org",
      "host": "stroke.ahajournals.org",
      "snippet": "Blood pressure (BP) lowering is often conducted as part of general acute management in patients with acute intracerebral hemorrhage.",
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    {
      "number": 4,
      "title": "The Importance of Acute Hypertensive Response in ICH | Stroke",
      "detail": "stroke.ahajournals.org",
      "url": "https://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.111.000758",
      "authors": "stroke.ahajournals.org",
      "host": "stroke.ahajournals.org",
      "snippet": "Acute hypertensive response is the elevation of blood pressure (BP) above normal and premorbid values that initially occurs within the first 24 hours of",
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    {
      "number": 5,
      "title": "Mediation effects of mean Hounsfield unit on relationship between hemoglobin and expansion of intracerebral hemorrhage | Scientific Reports",
      "detail": "www.nature.com",
      "url": "https://www.nature.com/articles/s41598-021-96790-x",
      "authors": "www.nature.com",
      "host": "www.nature.com",
      "snippet": "(2018).\"). The second model was additionally adjusted with baseline systolic blood pressure (> 140 mmHg or not) and location of hematoma (lobar vs. non-lobar) which were statistically significant in bivariate analysis. The relationships between volume difference and the mean HU and hemoglobin were e",
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      "number": 6,
      "title": "Acute Fatal Deterioration in Putaminal Hemorrhage",
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      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "_Background_ Clinical deterioration in patients with spontaneous intracerebral hemorrhage has rarely been studied. Acute deterioration with loss of all brain stem reflexes except for cornea reflexes was associated with a large increase in volume of the hematoma, 7 hours after the initial hemorrhage.",
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      "number": 7,
      "title": "Labetalol Use Is Associated With Increased In-Hospital Infection Compared With Nicardipine Use in Intracerebral Hemorrhage",
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      "url": "https://www.ahajournals.org/doi/10.1161/strokeaha.117.017230",
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      "snippet": "Labetalol Use Is Associated With Increased In-Hospital Infection Compared With Nicardipine Use in Intracerebral Hemorrhage | Stroke. Labetalol Use Is Associated With Increased In-Hospital Infection Compared With Nicardipine Use in Intracerebral Hemorrhage. Intracerebral hemorrhage (ICH) is a devasta",
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      "detail": "www.ahajournals.org",
      "url": "https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.036139",
      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "intensive blood pressure lowering and DWI lesions in intracerebral hemorrhage: exploratory analysis of the ATACH-2 randomized trial.",
      "score": 0.7304634
    },
    {
      "number": 9,
      "title": "Acute Blood Pressure Management in Intracerebral Hemorrhage",
      "detail": "www.ahajournals.org",
      "url": "https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.015060",
      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "There was no effect on the frequency of hematoma expansion, although the trend was in favor of more aggressive BP reduction (18.9% versus 24.4%",
      "score": 0.7192461
    },
    {
      "number": 10,
      "title": "Rate and Predictors of Unanticipated Surgical Evacuation in Patients with Intracerebral Hemorrhage: Post Hoc Analysis of ATACH 2 Trial - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S1878875020313474",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "### Lancet Neurol\n\n### Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association\n\n### Stroke\n\n### Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II: design, methods,",
      "score": 0.7206637
    },
    {
      "number": 11,
      "title": "Intracerebral hemorrhage outcome: A comprehensive update",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/pii/S0022510X19300139",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "INTERACT2. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N. Engl. J. Med., 368 (2013), pp. 2355-2365, 10.1056",
      "score": 0.70287734
    },
    {
      "number": 12,
      "title": "Early Intensive Blood Pressure Reduction After Intracerebral Hemorrhage Is Associated With Worse Functional Outcome: The Risk of Overshooting Blood Pressure Goals - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S0196064425013034",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "### Stroke\n\n### 2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association\n\n### Stroke\n\n### Ultra-early blood pressure reduction attenuates hematoma growth and improves outcome in intracerebral ",
      "score": 0.7023877
    },
    {
      "number": 13,
      "title": "Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S1474442214700183",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "### Stroke\n\n### Antihypertensive treatment of acute cerebral hemorrhage (ATACH): rationale and design\n\n### Neurocrit Care\n\n### Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage\n\n### N Engl J Med\n\n### International Society of Hypertension (ISH): statement on the management",
      "score": 0.6952351
    },
    {
      "number": 14,
      "title": "Intracerebral Hemorrhage - Continuum",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/continuum/fulltext/2021/10000/intracerebral_hemorrhage.6.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "Systolic blood pressure has been found to be associated with hematoma volume. Hematoma expansion occurs in up to 38% of patients with ICH and represents a",
      "score": 0.66959417
    },
    {
      "number": 15,
      "title": "Personalized Blood Pressure Targeting After... : JAMA Neurology",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/01714639-900000000-96433",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "Participants were randomly assigned (1:1) to a reperfusion-guided systolic BP strategy (140-160 mm Hg for mTICI score of 2b; 100-140 mm Hg for mTICI score of 2c",
      "score": 0.6202772
    },
    {
      "number": 16,
      "title": "Intensive Systolic Blood Pressure Control After Intracerebral ...",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/neurotodayonline/fulltext/2025/06190/new_aan_report_reviews_the_state_of_evidence_on.4.aspx",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "Dr. Butcher said that all neurologists who treat ICH should set a target for SBP of less than 140 mmHg. “Unfortunately, even at teaching centers",
      "score": 0.5883458
    },
    {
      "number": 17,
      "title": "Antihypertensive treatment of acute cerebral... : Critical Care Medicine",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/ccmjournal/fulltext/10.1097/ccm.0b013e3181b9e1a5~antihypertensive-treatment-of-acute-cerebral-hemorrhage",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "## Conclusions:\n\nThe observed proportions of neurologic deterioration and serious adverse events were below the prespecified safety thresholds, and the 3-month mortality rate was lower than expected in all systolic blood pressure tiers. The results form the basis of a larger randomized trial address",
      "score": 0.4603137
    },
    {
      "number": 18,
      "title": "Blood Pressure Goals in Acute Stroke - Oxford Academic",
      "detail": "academic.oup.com",
      "url": "https://academic.oup.com/ajh/article/35/6/483/6552292",
      "authors": "academic.oup.com",
      "host": "academic.oup.com",
      "snippet": "A systolic blood pressure goal of 140 mm Hg is probably appropriate for acute hemorrhagic stroke. The blood pressure goal in acute ischemic stroke, however, is",
      "score": 0.40443742
    },
    {
      "number": 19,
      "title": "Intensive Blood Pressure Reduction and Perihematomal Edema ...",
      "detail": "uat.ajnr.org",
      "url": "https://uat.ajnr.org/lookup/external-ref?access_num=10.1161%2FSTROKEAHA.119.024838&link_type=DOI",
      "authors": "uat.ajnr.org",
      "host": "uat.ajnr.org",
      "snippet": "In conclusion, we demonstrate that intensive BP reduction is associated with decreased PHER in ATACH-2 patients with deep ICH. Although PHER was",
      "score": 0.5015387
    },
    {
      "number": 20,
      "title": "Lower Treatment Blood Pressure Is Associated With Greatest ...",
      "detail": "uat.ajnr.org",
      "url": "https://uat.ajnr.org/lookup/external-ref?access_num=10.1161%2FHYPERTENSIONAHA.110.154328&link_type=DOI",
      "authors": "uat.ajnr.org",
      "host": "uat.ajnr.org",
      "snippet": "The main results from the pilot phase of INTERACT showed that early intensive BP lowering reduced hematoma growth in patients treated within 6",
      "score": 0.4054258
    },
    {
      "number": 21,
      "title": "Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage | Neurology",
      "detail": "www.neurology.org",
      "url": "https://www.neurology.org/doi/10.1212/WNL.0000000000006156",
      "authors": "www.neurology.org",
      "host": "www.neurology.org",
      "snippet": "# Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage. To determine the incidence and predictors of acute cerebral ischemia and neurologic deterioration in intracerebral hemorrhage (ICH) patients after an institutional protocol change in systolic blood pr",
      "score": 0.76490957
    },
    {
      "number": 22,
      "title": "Systolic blood pressure after intravenous antihypertensive treatment and clinical outcomes in hyperacute intracerebral hemorrhage: the stroke acute management with urgent risk-factor assessment and improvement-intracerebral hemorrhage study - PubMed",
      "detail": "www.ncbi.nlm.nih.gov",
      "url": "http://www.ncbi.nlm.nih.gov/pubmed/23704107",
      "authors": "www.ncbi.nlm.nih.gov",
      "host": "www.ncbi.nlm.nih.gov",
      "snippet": "An official website of the United States government. Federal government websites often end in .gov or .mil. official website and that any information you provide is encrypted. ## Save citation to file. ### Add to Collections. ### Add to My Bibliography. # Systolic blood pressure after intravenous an",
      "score": 0.7043437
    },
    {
      "number": 23,
      "title": "The systolic blood pressure sweet spot after intracerebral hemorrhage",
      "detail": "www.neurology.org",
      "url": "https://www.neurology.org/doi/10.1212/01.wnl.0000544245.04683.a1",
      "authors": "www.neurology.org",
      "host": "www.neurology.org",
      "snippet": "Title: The systolic blood pressure sweet spot after intracerebral hemorrhage\nImage 1: Go to homepage. *   Image 2: American Academy of Neurology. Image 3: American Academy of Neurology Logo. The most widely read and highly cited peer-reviewed neurology journal. # The systolic blood pressure sweet sp",
      "score": 0.6461259
    },
    {
      "number": 24,
      "title": "Comparative Efficacy and Safety of Clevidipine Versus Nicardipine in Hypertensive Emergencies: A Systematic Review and Meta‐Analysis",
      "detail": "pmc.ncbi.nlm.nih.gov",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13373942",
      "authors": "pmc.ncbi.nlm.nih.gov",
      "host": "pmc.ncbi.nlm.nih.gov",
      "snippet": "From a clinical perspective, the findings support the use of either clevidipine or nicardipine for acute SBP control in hypertensive emergencies and neurocritical settings. Both of the agents have comparable time to target SBP, and both of them demonstrated similar safety profiles. Therefore, the ag",
      "score": 0.74229145
    }
  ],
  "publishedAt": "2026-09-15T21:14:26.776330+00:00",
  "updatedAt": "2026-09-15T21:14:26.776330+00:00",
  "readingMinutes": 5,
  "slug": "ich-blood-pressure-management"
}