{
  "schemaVersion": 2,
  "eyebrow": "Nephrology",
  "title": "Hyponatremia Correction Limits",
  "summary": "For symptomatic hyponatremia, achieve an early 4-6 mEq/L sodium rise to reverse cerebral edema, then limit further correction according to chronicity and osmotic demyelination risk. Unknown duration should be managed as chronic, with frequent sodium measurements and prompt relowering after excess correction.",
  "seoDescription": "Practical sodium correction limits for acute and chronic hyponatremia, including hypertonic saline targets, ODS risk factors, monitoring, and relowering.",
  "clinicalQuestion": "What serum sodium correction targets and limits minimize cerebral edema while preventing osmotic demyelination in hyponatremia?",
  "specialty": "Nephrology and Hospital Medicine",
  "audience": "U.S. physicians and medical trainees",
  "tags": [
    "hyponatremia correction rate",
    "hypertonic saline",
    "osmotic demyelination syndrome",
    "desmopressin clamp",
    "sodium relowering",
    "3% saline"
  ],
  "keyTakeaways": [
    "For moderate or severe symptomatic hyponatremia, use 3% hypertonic saline to obtain an initial serum sodium increase of approximately 4-6 mEq/L; this is an acute neurologic-rescue target, not a target to normalize sodium. [8][13][15]",
    "If hyponatremia has lasted more than 48 hours or duration is unknown, treat it as chronic and generally target 5-8 mEq/L correction over 24 hours; use a lower target in patients at high risk for osmotic demyelination syndrome (ODS). [15]",
    "A sodium increase exceeding 10-12 mEq/L in 24 hours or 18 mEq/L in 48 hours constitutes potentially dangerous overcorrection; a more conservative ceiling is appropriate with sodium 105 mEq/L or lower, alcohol use disorder, malnutrition, hypokalemia, cirrhosis, or advanced liver disease. [11][14][15][18]",
    "The usual cause of unintended rapid correction is emergence of dilute-water diuresis after reversal of hypovolemia, medication effect, or cortisol deficiency; monitor serum sodium closely during active therapy and respond to trajectory rather than waiting for the daily limit to be crossed. [8][10]",
    "In chronic or unknown-duration hyponatremia with excessive correction, especially in patients with ODS risk factors, consider therapeutic relowering with free water and/or desmopressin to return sodium just below the intended correction limit. [14][15][17]"
  ],
  "sections": [
    {
      "id": "set-the-correction-goal",
      "eyebrow": "First decision",
      "heading": "Set the sodium goal by neurologic urgency and chronicity",
      "intro": "Separate the initial rescue increment from the 24- and 48-hour correction ceiling.",
      "paragraphs": [
        "In moderate or severe symptomatic hyponatremia, administer 3% hypertonic saline to produce a prompt initial serum sodium increase of about 4-6 mEq/L. This early increment is intended to mitigate cerebral edema and neurologic complications; stop escalating hypertonic saline when that increment is achieved or symptoms improve, then reset management around correction limits. [8][13][15]",
        "When onset is established as acute, the immediate danger from hyponatremic encephalopathy may justify urgent hypertonic saline. When duration exceeds 48 hours or cannot be established, assume chronic hyponatremia because brain osmotic adaptation makes rapid correction hazardous. For chronic hyponatremia, a typical target is 5-8 mEq/L during the first 24 hours, with a lower target for patients predisposed to ODS. [11][15]",
        "Do not pursue a normal sodium concentration during the initial treatment period. The clinically important endpoint is neurologic stabilization after a limited early rise, followed by a controlled daily trajectory. In patients without severe symptoms, correction should be gradual; one cited recommendation limits correction to 5 mEq/L per day in this setting. [2][4]"
      ],
      "bullets": [
        "Moderate or severe neurologic symptoms: obtain an early 4-6 mEq/L serum sodium rise with 3% saline, then reassess symptoms and correction trajectory. [8][13][15]",
        "Chronic or unknown-duration hyponatremia: plan a 5-8 mEq/L increase over 24 hours; select the low end when ODS risk is present. [15]",
        "Asymptomatic hyponatremia: avoid urgent normalization; use gradual correction rather than hypertonic-saline-driven rapid correction. [2][4]"
      ],
      "subsections": [],
      "table": {
        "caption": "Correction targets differ between emergency neurologic rescue and subsequent protection from ODS. [8][11][15]",
        "columns": [
          "Clinical situation",
          "Immediate sodium objective",
          "Subsequent limit or target",
          "Decision consequence"
        ],
        "rows": [
          [
            "Moderate or severe symptomatic hyponatremia",
            "Increase serum sodium by approximately 4-6 mEq/L promptly with 3% saline. [8][13][15]",
            "After the rescue increment, manage according to chronicity and ODS risk. [15]",
            "Do not continue hypertonic saline simply to normalize sodium. [15]"
          ],
          [
            "Chronic hyponatremia (>48 hours)",
            "No separate rapid-normalization target. [15]",
            "Typical 24-hour target: 5-8 mEq/L. [15]",
            "Use slower correction when ODS risk factors are present. [15][18]"
          ],
          [
            "Unknown duration",
            "Treat as chronic for safety. [15]",
            "Typical 24-hour target: 5-8 mEq/L, lower if high risk. [15]",
            "Avoid assuming acute physiology based on symptom severity alone. [15]"
          ],
          [
            "No severe symptoms",
            "Gradual correction rather than emergency sodium elevation. [2][4]",
            "One recommendation caps correction at 5 mEq/L per day. [2]",
            "Prioritize treatment of the reversible cause and avoid overshoot. [8]"
          ]
        ]
      }
    },
    {
      "id": "identify-ods-risk",
      "eyebrow": "Risk stratification",
      "heading": "Use ODS risk factors to choose the conservative correction limit",
      "intro": "The lower the starting sodium and the greater the osmotic vulnerability, the less room exists for correction error.",
      "paragraphs": [
        "Classify a patient as high risk for ODS when severe chronic or presumed chronic hyponatremia coexists with serum sodium 105 mEq/L or lower, alcohol use disorder, malnutrition, hypokalemia, cirrhosis, or advanced liver disease. These factors should move the correction plan toward the lowest practical daily target and lower the threshold for proactive control of water diuresis. [14][15][18]",
        "Rapid correction is a major modifiable risk factor, but ODS is multifactorial and uncommon; nevertheless, correction limits remain the safety standard because neurologic injury can be severe. Reported manifestations include dysarthria, mutism, dysphagia, lethargy, affective change, spastic quadriparesis, seizures, coma, and death. [6][17][18]",
        "Correct hypokalemia while recognizing that potassium administration can contribute to an increase in serum sodium and overall effective tonicity. In a patient with profound hyponatremia and hypokalemia, incorporate the expected sodium effect of potassium repletion into the daily correction budget rather than treating potassium replacement as separate from the sodium plan. [2][15]"
      ],
      "bullets": [
        "High-risk baseline features: sodium 105 mEq/L or lower, alcohol use disorder, malnutrition, hypokalemia, cirrhosis, or advanced liver disease. [14][15][18]",
        "Correction above 12 mEq/L in 24 hours is specifically associated with ODS risk; high-risk patients warrant slower correction than this outer threshold. [15][18]",
        "Document the presumed duration, initial sodium, potassium status, liver disease, nutritional status, and alcohol history before selecting a correction ceiling. [14][15]"
      ],
      "subsections": [],
      "table": {
        "caption": "Features that should trigger a conservative correction strategy and readiness to relower sodium. [14][15][18]",
        "columns": [
          "ODS risk feature",
          "Why it changes management",
          "Operational response"
        ],
        "rows": [
          [
            "Serum sodium 105 mEq/L or lower",
            "Extremely low initial sodium is a recognized ODS risk factor. [14][15]",
            "Use the low end of correction targets and act early if sodium is rising faster than planned. [14][15]"
          ],
          [
            "Alcohol use disorder or malnutrition",
            "Both are recognized ODS risk factors. [14][15][18]",
            "Avoid permissive correction and consider desmopressin if a water diuresis threatens the target. [8][9][14]"
          ],
          [
            "Hypokalemia",
            "Hypokalemia increases ODS susceptibility and potassium replacement can affect sodium correction. [2][15]",
            "Replete potassium while counting its contribution to the net correction trajectory. [2]"
          ],
          [
            "Cirrhosis or advanced liver disease",
            "Advanced liver disease is a recognized ODS risk factor. [14][15][18]",
            "Favor slower correction and therapeutic relowering after excessive correction. [14][18]"
          ]
        ]
      }
    },
    {
      "id": "deliver-hypertonic-saline",
      "eyebrow": "Acute treatment",
      "heading": "Use 3% saline for symptomatic rescue, with bolus dosing favored for the initial response",
      "intro": "Choose a regimen that achieves a measurable early rise while preserving the ability to stop quickly.",
      "paragraphs": [
        "Hypertonic 3% saline is indicated for hyponatremia with moderate or severe symptoms to prevent neurologic complications. Expert guidelines favor intermittent bolus therapy over a traditional continuous infusion for a faster initial sodium rise. In symptomatic SIAD, 100 mL boluses of 3% saline repeated up to two times produced a median 6-hour sodium increase of 6 mmol/L versus 3 mmol/L with 20 mL/hour continuous infusion, with greater improvement in Glasgow Coma Scale at 6 hours. [8][12][13]",
        "A third 100 mL bolus was associated with substantially greater use of dextrose and/or desmopressin to prevent overcorrection in the SIAD comparison study. Therefore, obtain an early sodium measurement and clinical reassessment before further boluses; do not reflexively complete a three-bolus sequence after the patient has achieved a 4-6 mEq/L rise or meaningful neurologic improvement. [13][15]",
        "Continuous infusion remains an alternative in selected settings, but its principal tradeoff is less immediate control of symptoms versus the need for sustained, closely monitored delivery. Comparative evidence has not established a clear difference in overcorrection, ODS, or mortality between rapid intermittent bolus and slow continuous infusion strategies, while bolus treatment achieves a faster early sodium increase. [13][16]"
      ],
      "bullets": [
        "Use 3% saline when moderate or severe symptoms are attributable to hyponatremia. [8][12]",
        "A studied bolus regimen for symptomatic SIAD was 3% saline 100 mL IV, repeatable up to two times; reassess serum sodium and neurologic status before each additional bolus. [13]",
        "Stop the emergency phase after a 4-6 mEq/L increase or symptom improvement, then constrain further correction by the 24-hour plan. [13][15]"
      ],
      "subsections": [],
      "table": {
        "caption": "Bolus and continuous 3% saline differ chiefly in early sodium response and ability to pause therapy. [13][16]",
        "columns": [
          "Strategy",
          "Reported regimen",
          "Early response",
          "Practical safety implication"
        ],
        "rows": [
          [
            "Intermittent bolus",
            "3% saline 100 mL IV, repeated up to two times in symptomatic SIAD. [13]",
            "Median sodium increase at 6 hours: 6 mmol/L. [13]",
            "Reassess before additional boluses because a third bolus was associated with greater need for dextrose/desmopressin to prevent overcorrection. [13]"
          ],
          [
            "Continuous infusion",
            "3% saline 20 mL/hour in the comparator SIAD cohort. [13]",
            "Median sodium increase at 6 hours: 3 mmol/L. [13]",
            "Requires ongoing sodium monitoring; comparative data show no clear outcome advantage for overcorrection, ODS, or mortality. [16]"
          ]
        ]
      }
    },
    {
      "id": "monitor-and-prevent-overshoot",
      "eyebrow": "Active management",
      "heading": "Detect water diuresis before the correction limit is exceeded",
      "intro": "Overcorrection often occurs when the cause of antidiuresis reverses, not because too much 3% saline was prescribed.",
      "paragraphs": [
        "Measure serum sodium frequently during active 3% saline treatment and whenever urine output rises or the clinical driver of antidiuresis is reversed. Reversal of hypovolemia, discontinuation of an offending medication, or treatment of cortisol deficiency can restore dilute urine excretion and increase serum sodium by more than 2 mEq/L per hour within a few hours. [8][10]",
        "Use the sodium trajectory—not only the absolute sodium value—to decide whether to stop hypertonic saline, replace free-water losses, or add desmopressin. A rising sodium concentration despite cessation of hypertonic saline suggests an evolving aquaresis; in chronic or unknown-duration hyponatremia, this warrants immediate intervention before the planned daily increment is surpassed. [8][9][15]",
        "Desmopressin can be used with hypertonic saline as a proactive clamp or reactively when a water diuresis develops. By increasing collecting-duct water reabsorption, it limits renal free-water clearance and permits more controlled sodium correction. Retrospective and heterogeneous studies suggest concurrent proactive desmopressin plus hypertonic saline reduces overcorrection, but dosing and timing strategies remain variable. [8][9][11]"
      ],
      "bullets": [
        "Watch for dilute-water diuresis after saline repletion, withdrawal of causative medications, or treatment of cortisol deficiency. [8]",
        "If sodium is rising faster than the planned trajectory, stop ongoing hypertonic saline and initiate measures to limit or reverse the increase rather than waiting for a 24-hour threshold. [9][14][15]",
        "Consider a desmopressin clamp in severe hyponatremia at high risk for overcorrection, recognizing that the supporting evidence is largely retrospective and regimen-dependent. [9][11]"
      ],
      "subsections": [
        {
          "heading": "Correction ceilings that should trigger action",
          "paragraphs": [
            "Use 10 mEq/L in 24 hours and 18 mEq/L in 48 hours as clear outer limits cited for chronic hyponatremia, while recognizing that many clinicians choose a 5-8 mEq/L daily target and lower limits for high-risk patients. A rise greater than 12 mEq/L in 24 hours is specifically identified in FDA labeling as associated with ODS risk; it is not a safe target. [11][15][18]"
          ],
          "bullets": [
            "Typical chronic-hyponatremia target: 5-8 mEq/L in 24 hours. [15]",
            "Potential overcorrection threshold: greater than 10 mEq/L in 24 hours. [15]",
            "Outer limits cited in expert recommendations: do not exceed 10 mEq/L in any 24 hours or 18 mEq/L in 48 hours. [11]",
            "FDA labeling identifies correction greater than 12 mEq/L in 24 hours as a risk for serious neurologic sequelae. [18]"
          ]
        }
      ],
      "table": null
    },
    {
      "id": "respond-to-overcorrection",
      "eyebrow": "Rescue",
      "heading": "Relower sodium after excessive correction in chronic or unknown-duration hyponatremia",
      "intro": "Relowering is most compelling when severe baseline hyponatremia and ODS susceptibility coexist.",
      "paragraphs": [
        "Consider therapeutic relowering when plasma sodium was below 120 mEq/L and hyponatremia is chronic or of unknown duration, correction has been excessively rapid, and the patient has ODS risk factors. The practical goal is not to return to the presenting sodium but to bring sodium just below the correction limit. This recommendation is based on expert opinion and low-quality evidence, but it is supported by case-based experience and is most relevant in patients with sodium 105 mEq/L or lower, alcohol use disorder, cirrhosis, malnutrition, or hypokalemia. [14][15]",
        "Use intravenous free water and/or desmopressin to relower or arrest the sodium rise after overshoot. Continue close serum sodium monitoring while implementing relowering because the intervention must be titrated to the current correction increment and ongoing urine water losses. [14][15][17]",
        "New dysarthria, dysphagia, mutism, spastic weakness, seizures, or declining consciousness after rapid correction should prompt urgent neurologic evaluation for ODS while sodium management is reassessed. ODS may present with severe delayed neurologic deficits, and its risk is amplified by rapid correction in vulnerable patients. [6][17][18]"
      ],
      "bullets": [
        "Consider relowering if chronic or unknown-duration hyponatremia with starting sodium below 120 mEq/L has corrected too rapidly, particularly when ODS risks are present. [14]",
        "Use free water and/or desmopressin to bring sodium just under the applicable correction limit. [14][15][17]",
        "Treat a correction trajectory as an emergency even if the patient is temporarily asymptomatic; prevention of ODS depends on intervening before sustained excessive osmotic stress. [14][15]"
      ],
      "subsections": [],
      "table": {
        "caption": "A practical response framework for sodium overcorrection in presumed chronic hyponatremia. [14][15][17]",
        "columns": [
          "Finding",
          "Immediate action",
          "Goal"
        ],
        "rows": [
          [
            "Sodium rising faster than planned but correction limit not yet exceeded",
            "Stop further hypertonic saline; assess for water diuresis and consider desmopressin to limit free-water clearance. [8][9]",
            "Prevent crossing the individualized 24-hour target. [15]"
          ],
          [
            "Excessive correction in chronic or unknown-duration hyponatremia",
            "Use intravenous free water and/or desmopressin. [14][15][17]",
            "Relower serum sodium to just below the correction limit. [14]"
          ],
          [
            "Excessive correction plus ODS risk factors",
            "Prioritize therapeutic relowering and intensive sodium-trajectory monitoring. [14][15]",
            "Reduce osmotic injury risk in the highest-risk group. [14][15]"
          ],
          [
            "New neurologic deficits after rapid correction",
            "Urgently reassess sodium management and evaluate for ODS. [6][17][18]",
            "Identify severe neurologic complication while avoiding further excess correction. [18]"
          ]
        ]
      }
    }
  ],
  "faq": [
    {
      "question": "Should an unknown duration of hyponatremia be treated as acute or chronic?",
      "answer": "Treat unknown-duration hyponatremia as chronic for correction planning. After an initial 4-6 mEq/L rescue increment if symptoms require it, use gradual correction, typically 5-8 mEq/L over 24 hours and lower targets for ODS-risk patients. [13][15]"
    },
    {
      "question": "Does a sodium rise greater than 12 mEq/L in 24 hours ever represent an intended target?",
      "answer": "No. A rise greater than 12 mEq/L in 24 hours is identified as a risk for ODS and serious neurologic sequelae; chronic hyponatremia is generally managed with lower targets, commonly 5-8 mEq/L per 24 hours. [15][18]"
    }
  ],
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  "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.",
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      "title": "Rapid Bolus vs. Continuous Infusion of Hypertonic Saline for Hyponatremia | NEJM Clinician",
      "detail": "clinician.nejm.org",
      "url": "https://clinician.nejm.org/rapid-bolus-vs-continuous-infusion-hypertonic-saline-hyponatremia-nejm-jw.NA52723",
      "authors": "clinician.nejm.org",
      "host": "clinician.nejm.org",
      "snippet": "Copyright © 2026\n\nMassachusetts Medical Society.\n\nAll rights reserved, including those for text and data mining, AI training, and similar technologies.\n\nElectronic ISSN 3067-1876\n\nThe content of this site is intended for health care professionals.\n\n# Rapid Bolus vs. Continuous Infusion of Hypertonic",
      "score": 0.55391616
    },
    {
      "number": 2,
      "title": "Hyponatremia in Acute Decompensated Heart Failure: Depletion Versus Dilution",
      "detail": "www.jacc.org",
      "url": "https://www.jacc.org/doi/10.1016/j.jacc.2014.12.010",
      "authors": "www.jacc.org",
      "host": "www.jacc.org",
      "snippet": "Crossref\n\nPubMed\n\nGoogle Scholar\n\n59.\n\nSpasovski G., Vanholder R., Allolio B. et al: Clinical practice guideline on diagnosis and treatment of hyponatraemia. _Intensive Care Med_ 2014; 40: 320.\n\nCrossref\n\nPubMed\n\nGoogle Scholar\n\n60.\n\nPirzada N.A. and Ali I.I.: Central pontine myelinolysis. _Mayo Cli",
      "score": 0.5324014
    },
    {
      "number": 3,
      "title": "Principles of Management of Severe Hyponatremia | Journal of the ...",
      "detail": "www.ahajournals.org",
      "url": "https://www.ahajournals.org/doi/abs/10.1161/jaha.112.005199",
      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "Osmotic Demyelination Syndrome Following Rapid Correction of Hyponatremia in a Young Woman: A Case Report and Review of Literature, Cureus, (2025).https",
      "score": 0.49611887
    },
    {
      "number": 4,
      "title": "Part 10.1: Life-Threatening Electrolyte Abnormalities | Circulation",
      "detail": "www.ahajournals.org",
      "url": "https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.166563",
      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "Correction of asymptomatic hyponatremia should be gradual: typically increase the Na+ by 0.5 mEq/L per hour to a maximum change of about 12 mEq/",
      "score": 0.468621
    },
    {
      "number": 5,
      "title": "Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center’s Experience",
      "detail": "www.jacc.org",
      "url": "https://www.jacc.org/doi/10.1016/j.jchf.2019.10.012",
      "authors": "www.jacc.org",
      "host": "www.jacc.org",
      "snippet": "that, with appropriate patient selection, administration of HS to an ADHF patient does not obligatorily result in worsening pulmonary edema and hypoxemia. Additionally, an excessive correction of serum sodium in this series was not seen, as the median change in serum sodium 24 h after HS administrat",
      "score": 0.4041552
    },
    {
      "number": 6,
      "title": "Principles of Management of Severe Hyponatremia",
      "detail": "www.ahajournals.org",
      "url": "https://www.ahajournals.org/doi/10.1161/jaha.112.005199",
      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "Overcorrection of chronic hyponatremia may lead to osmotic myelinolysis,,,, whereas undercorrection may fail to prevent life‐threatening",
      "score": 0.39229083
    },
    {
      "number": 7,
      "title": "Hyponatremia and Worsening Sodium Levels Are Associated With ...",
      "detail": "www.ahajournals.org",
      "url": "https://www.ahajournals.org/doi/10.1161/jaha.115.002668",
      "authors": "www.ahajournals.org",
      "host": "www.ahajournals.org",
      "snippet": "A correction of hyponatremia during hospitalization was associated with less subsequent mortality and heart failure readmission. In the subgroup",
      "score": 0.19511858
    },
    {
      "number": 8,
      "title": "Hypertonic Saline for Hyponatremia: Meeting Goals and Avoiding Harm - ScienceDirect",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/pii/S0272638621008386",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "Hypertonic saline has been used for the treatment of hyponatremia for nearly a century. There is now general consensus that hypertonic saline should be used in patients with hyponatremia associated with moderate or severe symptoms to prevent neurological complications. This article considers these i",
      "score": 0.82220376
    },
    {
      "number": 9,
      "title": "Use of the Desmopressin Clamp in Hyponatremia : Kidney360",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/10.34067/KID.0000000953",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "In summary, the study by AlShanableh et al. adds to the growing evidence that proactive DDAVP, when used with hypertonic saline, may be an effective strategy for safely managing severe hyponatremia. Although limited by its retrospective design, the findings suggest that the “DDAVP clamp” can help re",
      "score": 0.784336
    },
    {
      "number": 10,
      "title": "Evaluation of Desmopressin in Critically Ill Patients with Hyponatremia Requiring 3% Hypertonic Saline",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S0002962921001038",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "or severe symptoms to prevent neurological complications. However, much less agreement exists among experts regarding other aspects of its use. Should hypertonic saline be administered as a bolus injection or continuous infusion? What is the appropriate dose? Is a central venous line necessary? Shou",
      "score": 0.77994305
    },
    {
      "number": 11,
      "title": "Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors?",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/pii/S0002962915301981",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "saline infusion. In this setting, desmopressin infusion helps prevent overcorrection of the hyponatremia. Monitoring of the changes in serum sodium concentration as a guide to treatment changes is imperative regardless of the initial treatment of severe hyponatremia. [...] To the authors’ knowledge,",
      "score": 0.7634314
    },
    {
      "number": 12,
      "title": "Hypertonic Saline for Hyponatremia: Meeting Goals and Avoiding Harm",
      "detail": "www.sciencedirect.com",
      "url": "https://www.sciencedirect.com/science/article/abs/pii/S0272638621008386",
      "authors": "www.sciencedirect.com",
      "host": "www.sciencedirect.com",
      "snippet": "Hypertonic saline has been used for the treatment of hyponatremia for nearly a century. There is now general consensus that hypertonic saline should be used in patients with hyponatremia associated with moderate or severe symptoms to prevent neurological complications. However, much less agreement e",
      "score": 0.75290436
    },
    {
      "number": 13,
      "title": "Continuous Versus Bolus Infusion of Hypertonic Saline in the Treatment of Symptomatic Hyponatremia Caused by SIAD | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic",
      "detail": "academic.oup.com",
      "url": "https://academic.oup.com/jcem/article/104/9/3595/5381922",
      "authors": "academic.oup.com",
      "host": "academic.oup.com",
      "snippet": "Title: Continuous Versus Bolus Infusion of Hypertonic Saline in the Treatment of Symptomatic Hyponatremia Caused by SIAD | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic\nExpert guidelines advocate the use of intravenous boluses of hypertonic saline rather than traditional conti",
      "score": 0.5125224
    },
    {
      "number": 14,
      "title": "Therapeutic Relowering of Plasma Sodium after... : Clinical Journal of the American Society of Nephrology",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/cjasn/fulltext/10.2215/cjn.04880419~therapeutic-relowering-of-plasma-sodium-after-overly-rapid",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "Therapeutic relowering of plasma sodium should be considered in patients with severe hyponatremia (plasma sodium <120 mEq/L) of chronic (>48 hours) or unknown duration who experience overly rapid correction particularly if risk factors for osmotic demyelination syndrome are present (i.e., alcohol us",
      "score": 0.7489592
    },
    {
      "number": 15,
      "title": "Syndrome of Inappropriate Antidiuresis : Endocrine Reviews",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/00003599-202309000-00003",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "Risk factors for ODS, other than an extremely low initial sodium concentration (eg, < 105 mmol/L) and rapid correction (eg, > 12 mmol/L in 24 hours), include hypokalemia, alcohol abuse, malnutrition, and advanced liver disease (Table 3) (3, 128, 129). These factors may impair the ability of glial ce",
      "score": 0.7382357
    },
    {
      "number": 16,
      "title": "Safety of Rapid Intermittent Bolus versus Slow... : Annals of African Medicine",
      "detail": "journals.lww.com",
      "url": "https://journals.lww.com/aoam/_layouts/15/oaks.journals/downloadpdf.aspx?an=01244624-202504000-00035",
      "authors": "journals.lww.com",
      "host": "journals.lww.com",
      "snippet": "## Results:\n\nData from three studies (290 patients) with severe hyponatremia was analyzed. Patients receiving RIB had a similar occurrence of overcorrection (relative risk [RR]: 1.59 [0.40, 6.35]; I2 = 61%; P = 0.51), need for relowering treatment to bring down serum sodium back to the normal range ",
      "score": 0.5889134
    },
    {
      "number": 17,
      "title": "[PDF] Pregnancy with Kidney Diseases Brings Joy and Challenges",
      "detail": "www.asn-online.org",
      "url": "https://www.asn-online.org/publications/kidneynews/archives/2023/KN_2023_08_aug.pdf",
      "authors": "www.asn-online.org",
      "host": "www.asn-online.org",
      "snippet": "correction of hyponatremia are uncertain. US and European clinical practice guidelines in 2013 and 2014, respectively, recommend limits of correction of between 8 and 10 mmol/L/24 hours, with re-lowering of the serum Na with free water or desmo-pressin if these limits are exceeded, for the preventio",
      "score": 0.8622012
    },
    {
      "number": 18,
      "title": "[PDF] Kidney News - October/November 2015 - American Society of ...",
      "detail": "www.asn-online.org",
      "url": "https://www.asn-online.org/publications/kidneynews/archives/2015/KN_2015_10_oct.pdf",
      "authors": "www.asn-online.org",
      "host": "www.asn-online.org",
      "snippet": "WARNINGS AND PRECAUTIONS: Too Rapid Correction of Serum Sodium Can Cause Serious Neurologic Sequelae (see BOXED WARNING): Osmotic demyelination syndrome is a risk associated with too rapid correction of hyponatremia (e.g., >12 mEq/L/24 hours). Osmotic demyelination results in dysarthria, mutism, dys",
      "score": 0.65146625
    },
    {
      "number": 19,
      "title": "[PDF] FDA Could Approve First Biosimilar Drug for Dialysis this Year",
      "detail": "www.asn-online.org",
      "url": "https://www.asn-online.org/publications/kidneynews/archives/2015/KN_2015_08_aug.pdf",
      "authors": "www.asn-online.org",
      "host": "www.asn-online.org",
      "snippet": "WARNINGS AND PRECAUTIONS: Too Rapid Correction of Serum Sodium Can Cause Serious Neurologic Sequelae (see BOXED WARNING): Osmotic demyelination syndrome is a risk associated with too rapid correction of hyponatremia (e.g., >12 mEq/L/24 hours). Osmotic demyelination results in dysarthria, mutism, dys",
      "score": 0.6016175
    },
    {
      "number": 20,
      "title": "Hyperglycemic Crises in Adults With Diabetes: A Consensus Report",
      "detail": "diabetesjournals.org",
      "url": "https://diabetesjournals.org/care/article/47/8/1257/156808/Hyperglycemic-Crises-in-Adults-With-Diabetes-A",
      "authors": "diabetesjournals.org",
      "host": "diabetesjournals.org",
      "snippet": "| Osmotic demyelination syndrome (117,178) | • Previously known as central pontine myelinolysis, osmotic demyelination syndrome can occur with rapid correction of hyponatremia. The incidence is unclear. | • The risk is specifically associated with rapid correction of hyponatremia.• May complicate tr",
      "score": 0.5717911
    },
    {
      "number": 21,
      "title": "Central Pontine Myelinolysis - Karger Publishers",
      "detail": "uat.ajnr.org",
      "url": "https://uat.ajnr.org/lookup/external-ref?access_num=10.1159%2F000047939&link_type=DOI",
      "authors": "uat.ajnr.org",
      "host": "uat.ajnr.org",
      "snippet": "In patients with chronic hyponatremia, the rate of correction should be less than 0.5 mmol/l/h [56][60]. The rapid correction of hyponatremia",
      "score": 0.46482924
    },
    {
      "number": 22,
      "title": "[PDF] NephroEconomics 2026: Costs and Innovation Pivotal for Kidney Care",
      "detail": "www.asn-online.org",
      "url": "https://www.asn-online.org/publications/kidneynews/archives/2026/KN_2026_06_jun.pdf",
      "authors": "www.asn-online.org",
      "host": "www.asn-online.org",
      "snippet": "10.1016/j.ejim.2025.04.012 5. MacMillan TE, et al. Osmotic demyelination syn-drome in patients hospitalized with hyponatremia. NEJM Evid 2023; 2:EVIDoa2200215. doi: 10.1056/ EVIDoa2200215 6. Donzé JD, et al. Impact of hyponatremia correction on the risk for 30-­ day readmission and death in patients",
      "score": 0.4434805
    },
    {
      "number": 23,
      "title": "RAPID CORRECTION OF CRITICAL HYPONATREMIA CAUSING ...",
      "detail": "journal.chestnet.org",
      "url": "https://journal.chestnet.org/article/S0012-3692(24)01964-0/fulltext",
      "authors": "journal.chestnet.org",
      "host": "journal.chestnet.org",
      "snippet": "Sodium correction of 8 to 12mmol/l in 24 hours is recommended in mild to moderate hyponatremia but in patients with severe hyponatremia of less than 120mmol/l,",
      "score": 0.43755972
    },
    {
      "number": 24,
      "title": "OVERCORRECTION OF SEVERE HYPONATREMIA: A MEDICAL ...",
      "detail": "journal.chestnet.org",
      "url": "https://journal.chestnet.org/article/S0012-3692(25)02192-0/fulltext",
      "authors": "journal.chestnet.org",
      "host": "journal.chestnet.org",
      "snippet": "For patients at low to moderate risk of ODS, no more than 4-8 mEq/L/day increase is recommended. For higher risk patients, a more conservative approach is used.",
      "score": 0.43568602
    }
  ],
  "publishedAt": "2026-09-15T21:43:42.062501+00:00",
  "updatedAt": "2026-09-15T21:43:42.062501+00:00",
  "readingMinutes": 7,
  "slug": "hyponatremia-correction-limits"
}