Updated October 2025
Perioperative Best Practices
Fluid and Electrolyte Management in Surgical Patients
Perioperative fluid and electrolyte therapy should target euvolemia, maintain perfusion, and avoid both overload and deficit. Evidence supports balanced crystalloids, individualized goal-directed strategies during major surgery, and vigilant electrolyte monitoring—especially in older adults and after GI surgery. Over- and under-resuscitation are each associated with harm, including AKI, pulmonary complications, ileus, and prolonged recovery.
Clinical question
How should fluids and electrolytes be managed across the perioperative continuum to optimize outcomes and minimize complications in adult surgical patients?
ERASGoal-directed therapyBalanced crystalloidsAKI preventionElectrolyte disordersGeriatric surgery
Key points
Risk Stratify and Set Goals
Estimate deficits, maintenance, and intraoperative losses. Define hemodynamic endpoints and urine output targets before incision [5].
Use Balanced Crystalloids First-Line
Goal-Directed Intraoperative Therapy
Prevent Overload and AKI
Stepwise Approach to Perioperative Fluids and Electrolytes
A structured, physiology-based plan reduces complications and supports ERAS pathways.
1
Preoperative Assessment and Optimization
Quantify volume status (history, exam, orthostatics, labs) and identify risks: diuretics, ACEi/ARB, CKD, HF, liver disease, older age, bowel prep. Correct hypovolemia with balanced crystalloids in small boluses (e.g., 250–500 mL) to clinical response. Review and address baseline dysnatremias, hypokalemia, and hypomagnesemia before anesthesia, which increase arrhythmia and AKI risk [5], [6].
2
Intraoperative Strategy
Use balanced crystalloids for maintenance and replacement. For major surgery, apply goal-directed therapy (GDT) using stroke volume or dynamic indices to guide 250 mL fluid challenges and vasopressors to meet MAP and perfusion targets, limiting positive balance [3], [5]. Avoid excessive chloride; consider minimal effective colloid when large volumes are needed with hemodynamic endpoints unmet, weighing renal risk [4], [5].
3
Immediate Postoperative Management
Target euvolemia with a conservative, needs-based plan. Track cumulative balance, daily weight, and urine output; de-escalate IV fluids as oral intake advances. Use isotonic solutions for maintenance in patients at risk of hyponatremia; avoid hypotonic fluids early post-op. Re-check electrolytes within 6–12 hours in high-risk patients or large intraop fluid shifts [5], [7], [15].
4
Ongoing Postoperative Care and De-resuscitation
Dosing, Monitoring, and Disorder-Specific Care
Operationalize best practices using concise, high-yield checklists.
Maintenance and Replacement
Maintenance: ~1–2 mL/kg/h balanced crystalloid; adjust for fever, drains, diuresis, renal/cardiac status [5].
Deficit: replace pre-op fasting deficit cautiously; avoid automatic 4-2-1 in older/frail patients [4], [6].
Blood loss: replace with balanced crystalloids initially; transfuse per thresholds and coagulation needs [5].
GI losses: match in type and volume (e.g., NG output with isotonic chloride-containing solution) with electrolyte repletion [5].
Monitoring and Targets
Hemodynamics: MAP, lactate, capillary refill, dynamic indices in ventilated patients for GDT [3], [5].
Renal: urine output ≥0.5 mL/kg/h as a guide; interpret with clinical context [5].
Avoiding Harm
Avoid liberal chloride-rich fluids that increase hyperchloremic acidosis and may worsen renal perfusion [4], [5].
Prevent fluid overload: positive balance is linked to pulmonary edema, ileus, and delayed recovery [2], [7].
Older Adult Considerations
Reduced thirst and renal concentrating ability heighten dehydration risk; start with lower maintenance rates [6].
Higher susceptibility to hyponatremia and orthostatic hypotension—use isotonic fluids and slower corrections [6].
Polypharmacy (diuretics, SSRIs) increases dysnatremia risk; monitor sodium closely [6].
Common Electrolyte Disorders
Hyponatremia: evaluate volume status; isotonic saline for hypovolemic; cautious correction (≤8 mEq/L/24 h) [5], [6].
Hypernatremia: free-water deficit replacement using enteral water or IV D5W; correct slowly to avoid cerebral edema [5].
Hypokalemia: replace 10–20 mEq KCl increments; correct Mg concurrently; ECG monitoring if severe [5], [13].
Hyperkalemia: membrane stabilization, shift (insulin/glucose), removal; review ACEi/ARB, K-sparing agents [5].
Hypocalcemia: treat symptomatic or severe with IV calcium; assess albumin, citrate load after transfusion [13].
When to Escalate
Persistent hypotension despite balanced fluid challenges and vasopressors—evaluate for bleeding/sepsis [5].
Worsening oxygenation, rising creatinine, or positive balance—initiate de-resuscitation strategies [2], [7].
Refractory electrolyte disturbances—consider endocrine, renal, or medication causes; involve ICU/nephrology [5].
References
Source material
Primary literature that informs this article.
Fluid and Electrolyte Management in Surgical Patients
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Fluid therapy for the surgical patient
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Review Fluid therapy in the intraoperative setting
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Perioperative fluid management: evidence-based ...
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The pathophysiology of fluid and electrolyte balance in ...
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How perioperative fluid balance influences postoperative ...
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Fluid and electrolyte management for the surgical patient
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Contemporary Approaches to Perioperative IV Fluid Therapy
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Fluid and Electrolyte Disorders in the Surgical Patient
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Perioperative Fluid and Electrolyte Management in Cardiac ...
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Fluid and electrolyte management for the surgical patient
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A close look at postoperative fluid management and ...
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