{ "schemaVersion": 2, "eyebrow": "Adult congenital cardiology", "title": "Coarctation of the Aorta", "summary": "Coarctation requires lifelong assessment for residual obstruction, hypertension, aneurysm, and associated bicuspid valve disease. Measure arm-leg pressures, define anatomy with cross-sectional imaging, intervene for hemodynamically significant obstruction, and maintain congenital cardiology surveillance after repair.", "seoDescription": "Point-of-care guidance for diagnosing, treating, and surveilling native or repaired aortic coarctation in children and adults.", "clinicalQuestion": "How should clinicians evaluate, treat, and longitudinally monitor native or repaired coarctation of the aorta?", "specialty": "Cardiology", "audience": "U.S. physicians and medical trainees", "tags": [ "aortic coarctation", "recoarctation", "adult congenital heart disease", "coarctation stent", "arm-leg blood pressure gradient", "coarctation pregnancy" ], "keyTakeaways": [ "Measure blood pressure in both arms and at least one leg and assess femoral pulse timing whenever coarctation or recoarctation is suspected; an upper-to-lower extremity cuff gradient of at least 20 mm Hg should prompt further evaluation for residual obstruction or reintervention. [18]", "Use transthoracic echocardiography for ventricular and valvular assessment, but obtain cardiovascular MR or CT angiography to define the entire arch, repair site, collateral circulation, and aneurysm burden, particularly in older children and adults with limited acoustic windows. [11][14][18]", "Treat significant native or recurrent coarctation when catheter peak-to-peak gradient is at least 20 mm Hg, or when a lower gradient accompanies anatomically important narrowing and substantial collateral flow. [16][20]", "Repair does not eliminate vascular risk: lifelong congenital cardiology follow-up must address recoarctation, repair-site aneurysm, persistent hypertension, and abnormal exercise blood-pressure response. [18][21][24]", "Before pregnancy, evaluate residual obstruction, hypertension, bicuspid aortic valve, thoracic aortic dimensions, and intracranial aneurysm risk; repair residual/recurrent coarctation when feasible before conception. [9]" ], "sections": [ { "id": "recognize-urgent-presentation", "eyebrow": "Immediate triage", "heading": "Identify ductal-dependent neonatal disease and high-risk late presentation", "intro": "Presentation and urgency differ sharply by age and ductal patency.", "paragraphs": [ "In a neonate or young infant, deterioration after ductal closure with heart failure or shock should trigger urgent evaluation for critical, ductal-dependent coarctation. Critical coarctation most often presents when the ductus closes; primary management in infants is surgical repair after stabilization and anatomic definition. [22]", "In adolescents and adults, suspect native coarctation or recoarctation in upper-extremity hypertension, a murmur, diminished or delayed femoral pulses, arm-leg pressure disparity, lower-extremity hypoperfusion symptoms, or unexplained left-ventricular hypertrophy. Untreated disease is associated with systemic hypertension, heart failure, aortic aneurysm or dissection, and premature mortality. [13][19]", "Do not use a low resting Doppler or cuff gradient to exclude clinically important obstruction when extensive collaterals are present. Collateral pathways can decompress the pressure gradient despite significant anatomic narrowing; define anatomy and collateral burden with cross-sectional imaging and use invasive hemodynamics when intervention is being considered. [16][20][21]" ], "bullets": [ "Document right-arm and leg blood pressures and pulse delay at the same encounter; the left-arm reading can be misleading when subclavian anatomy is involved. [13]", "Refer patients with suspected significant native or recurrent obstruction to an adult congenital heart disease or congenital heart center that can offer both catheter and surgical repair. Multidisciplinary selection is recommended because age, associated lesions, and arch anatomy determine the approach. [21]" ], "subsections": [], "table": { "caption": "Age-specific presentation patterns that change urgency and next testing. [13][19][22]", "columns": [ "Clinical setting", "Key discriminator", "Immediate next step" ], "rows": [ [ "Neonate or young infant with shock after ductal closure", "Possible ductal-dependent critical coarctation. [22]", "Urgent congenital cardiology/cardiac surgery assessment and anatomic evaluation. [22]" ], [ "Older child or adult with hypertension", "Arm-leg pressure difference, delayed femoral pulses, murmur, or LV hypertrophy support obstructive physiology. [13][19]", "Echocardiography plus MR angiography or CT angiography of the arch and thoracic aorta. [13][14]" ], [ "Previously repaired patient", "New hypertension, rising arm-leg gradient, or exercise hypertension may indicate recurrent obstruction or vascular dysfunction. [18][24]", "Repeat echocardiography and cross-sectional imaging; assess for reintervention threshold. [18]" ] ] } }, { "id": "diagnostic-workup", "eyebrow": "Diagnostic workup", "heading": "Confirm obstruction, define arch anatomy, and identify associated lesions", "intro": "Pair hemodynamics with imaging; neither alone reliably establishes clinical significance.", "paragraphs": [ "At initial assessment, obtain upper- and lower-extremity cuff pressures, complete pulse examination, transthoracic echocardiography, and ECG-based assessment for hypertensive cardiac effects. Echocardiography confirms obstructive physiology and assesses left-ventricular hypertrophy or dysfunction, aortic regurgitation, and associated bicuspid aortic valve disease. [13][9]", "Obtain cardiovascular MR angiography when feasible, or CT angiography when MR is unsuitable, to map the site and length of narrowing, transverse arch hypoplasia, collateral vessels, repair-site aneurysm or pseudoaneurysm, and thoracic aortic dimensions. MR provides superior visualization of the adult arch and collateral circulation compared with echocardiography and can estimate flow and peak gradient with phase-contrast analysis. [14]", "When noninvasive findings suggest clinically significant obstruction or are discordant, catheterization provides the peak-to-peak pressure gradient used for intervention decisions. A catheter peak-to-peak gradient is generally lower than the peak systolic gradient reported by Doppler echocardiography, so do not equate the two measurements. [20]" ], "bullets": [ "Use an upper-to-lower extremity cuff gradient of at least 20 mm Hg or an arch echocardiographic mean systolic gradient of at least 20 mm Hg as a threshold for additional evaluation or possible reintervention after repair. [18]", "For suspected significant coarctation, advanced imaging should accompany physiologic assessment; a mean Doppler or peak-to-peak gradient of at least 20 mm Hg is significant, as is a gradient of at least 10 mm Hg with reduced LV systolic function, aortic regurgitation, or collateral flow. [21]", "Screen specifically for bicuspid aortic valve by baseline echocardiography in patients contemplating pregnancy, and use baseline brain MRA to evaluate for berry aneurysms in the pregnancy assessment pathway. [9]" ], "subsections": [], "table": { "caption": "Interpretation of pressure gradients in native or repaired coarctation. [16][18][20][21]", "columns": [ "Finding", "Interpretation", "Action" ], "rows": [ [ "Catheter peak-to-peak gradient at least 20 mm Hg", "Hemodynamically significant coarctation. [16][20][21]", "Evaluate for catheter-based or surgical repair based on anatomy and patient factors. [19][21]" ], [ "Gradient below 20 mm Hg plus important narrowing and collateral flow", "Collaterals may mask severe obstruction. [16][20]", "Treat as potentially significant; integrate cross-sectional imaging and invasive assessment. [16][21]" ], [ "Gradient at least 10 mm Hg plus LV systolic dysfunction, aortic regurgitation, or collateral flow", "Significant obstruction under AHA-described physiologic criteria. [21]", "Obtain advanced imaging and refer for intervention assessment. [21]" ], [ "Cuff gradient or echo mean gradient at least 20 mm Hg after repair", "Threshold for further evaluation or possible reintervention. [18]", "Repeat anatomic imaging and evaluate residual or recurrent narrowing. [18]" ] ] } }, { "id": "intervention-selection", "eyebrow": "Definitive treatment", "heading": "Select surgery, stenting, or balloon angioplasty by age and anatomy", "intro": "The procedural objective is durable relief of obstruction without creating aortic wall injury.", "paragraphs": [ "For native or recurrent coarctation meeting hemodynamic or anatomic criteria, choose repair after multidisciplinary review of patient size, lesion length, arch hypoplasia, prior repair type, associated cardiac disease, and aneurysm anatomy. ACC/AHA guidance supports either surgical repair or percutaneous catheter intervention for recurrent discrete coarctation. [19][21]", "Surgery remains the primary treatment for infant coarctation and is particularly relevant when arch hypoplasia or complex anatomy requires reconstruction. In children with recurrent discrete coarctation, balloon angioplasty is a reasonable initial option; recurrent obstruction with arch hypoplasia more often requires surgical relief of the hypoplastic segments. [22]", "In older children, adolescents, and adults with anatomy suitable for a transcatheter approach, stent implantation is commonly used because a stent can be dilated toward adult size. In a multicenter cohort of children weighing more than 10 kg, surgery and stenting produced lower short-term upper-to-lower extremity gradients than balloon angioplasty; stenting had fewer reported complications than surgery or balloon angioplasty, whereas balloon angioplasty carried more aortic wall injury. [7][22]" ], "bullets": [ "Use balloon angioplasty cautiously as primary treatment of native infant coarctation: surgery remains first-line in many centers, and published infant balloon angioplasty series report reintervention rates of 14% to 49%; rates in infants younger than 3 months have been reported at 35% to 68%. [6]", "Counsel families that balloon angioplasty can cause aneurysm, femoral arterial injury, bleeding, aortic rupture, neurologic injury, or stroke; in one randomized comparison cited by NICE, aneurysm occurred in 20% after angioplasty versus 0% after surgery. [23]", "After any repair, investigate new hypertension or a rising arm-leg gradient for recurrent narrowing and investigate cross-sectional imaging evidence of dilation, aneurysm, or pseudoaneurysm at the repair site. [19][24]" ], "subsections": [ { "heading": "When not to defer repair", "paragraphs": [ "Do not defer intervention solely because the patient is asymptomatic when a catheter peak-to-peak gradient is at least 20 mm Hg or when a lower gradient coexists with clear anatomic coarctation and substantial collateral flow. Persistent obstruction is linked to progressive left-ventricular dysfunction, systolic hypertension, and premature cerebrovascular and coronary disease. [13][16][20]" ], "bullets": [] } ], "table": { "caption": "Procedure selection framework for coarctation repair. [6][7][19][22][23]", "columns": [ "Patient or anatomy", "Usually favored strategy", "Key tradeoff" ], "rows": [ [ "Neonate or infant with native critical coarctation", "Surgical repair. [22]", "Balloon angioplasty has higher reported early-life reintervention rates and is not the usual primary approach. [6][22]" ], [ "Young child with discrete recurrent coarctation", "Consider balloon angioplasty first. [22]", "Assess for aortic wall injury and future restenosis. [7][23]" ], [ "Recoarctation with arch hypoplasia", "Surgical reconstruction is often required. [22]", "Balloon treatment may not address multisegment arch obstruction. [22]" ], [ "Older child, adolescent, or adult with suitable discrete anatomy", "Transcatheter stent implantation. [7][22]", "Requires long-term surveillance for recurrent obstruction and aneurysm. [24]" ], [ "Recurrent discrete coarctation after prior repair", "Surgery or percutaneous catheter intervention. [19]", "Choose according to prior repair, anatomy, and concomitant disease. [19][21]" ] ] } }, { "id": "lifelong-surveillance", "eyebrow": "Long-term management", "heading": "Monitor hypertension, recurrent obstruction, and aortic complications for life", "intro": "An anatomically successful repair does not normalize lifetime vascular risk.", "paragraphs": [ "Arrange lifelong follow-up with a cardiologist experienced in adult congenital heart disease for all adults with native or repaired coarctation. Surveillance must include recurrent obstruction, systemic hypertension, aortic aneurysm formation, associated valve disease, and cardiovascular risk factors. [21][18][24]", "At follow-up, repeat arm-leg pressure assessment and echocardiography, with cross-sectional imaging used as an adjunct—especially in older children and adults whose arch imaging by echocardiography is limited. Younger patients and those with greater-than-mild residual lesions need closer surveillance; exercise testing can help detect an abnormal blood-pressure response. [18]", "Treat hypertension as an ongoing disease target rather than assuming it will resolve after repair. Blood pressure often falls after successful relief of obstruction, but persistent or recurrent hypertension and disproportionate exercise systolic hypertension remain common and contribute to premature coronary and cerebrovascular disease. [16][24]" ], "bullets": [ "Escalate imaging and reintervention assessment for an upper-to-lower extremity cuff gradient or arch echo mean systolic gradient of at least 20 mm Hg. [18]", "Use MR or CT surveillance to detect repair-site dilation, aneurysm, or pseudoaneurysm, which can occur after both surgical and endovascular treatment. [19][24]", "In patients with repaired coarctation, incorporate cardiovascular risk-factor counseling and assessment because vascular dysfunction and late atherosclerotic and cerebrovascular disease remain important sources of morbidity. [4][18]" ], "subsections": [], "table": { "caption": "Findings during follow-up that should change management. [16][18][19][24]", "columns": [ "Follow-up finding", "Likely concern", "Next action" ], "rows": [ [ "Arm-leg cuff gradient or echo mean gradient at least 20 mm Hg", "Residual or recurrent obstruction. [18]", "Obtain anatomic imaging and assess for reintervention. [18]" ], [ "New or persistent systemic hypertension", "Residual obstruction, vascular dysfunction, or both. [16][24]", "Reassess arch anatomy and address hypertension longitudinally. [16][18]" ], [ "Abnormal exercise blood-pressure response", "Exercise-induced hypertension despite repair. [16][18]", "Use exercise testing result to intensify surveillance and blood-pressure management. [18]" ], [ "Aortic dilation, aneurysm, or pseudoaneurysm", "Late repair-site aortic complication. [19][24]", "Refer to congenital/aortic multidisciplinary team for anatomic treatment planning. [19][21]" ] ] } }, { "id": "pregnancy-planning", "eyebrow": "Pregnancy", "heading": "Risk-stratify before conception and monitor blood pressure through postpartum", "intro": "Residual obstruction, hypertension, and aneurysm—not repaired status alone—drive pregnancy risk.", "paragraphs": [ "Women with repaired coarctation are classified as modified WHO II–III, while unrepaired severe coarctation is modified WHO IV. Before conception, assess residual obstruction, hypertension, bicuspid aortic valve, thoracic aortic anatomy and dimensions, and intracranial berry aneurysms with baseline MRA; repair residual or recurrent coarctation before pregnancy when feasible. [3][9]", "Pregnancy risk rises with residual obstruction defined by a gradient greater than 20 mm Hg or minimal aortic lumen less than 12 mm, hypertension, or aortic aneurysm. If aortic diameter exceeds 4.0 cm, consider serial noncontrast MRA during pregnancy. Individualize blood-pressure goals because excessive lowering may worsen fetal perfusion in the setting of residual coarctation. [9]", "Vaginal delivery is generally preferred and epidural analgesia is recommended in the cited congenital heart disease pregnancy framework. Consider cesarean delivery for ascending aortic aneurysm greater than 5.0 cm or acute aortic syndrome. Anticipate postpartum hypertension, with blood pressure expected to peak 3 to 8 days after delivery. [9]" ], "bullets": [ "Consider low-dose aspirin 81 mg daily beginning in the second trimester because hypertensive disorders of pregnancy have been reported in 30% of coarctation pregnancies in the cited framework. [9]", "Counsel regarding congenital heart disease recurrence in offspring; one cohort reported congenital heart disease in 4% of 109 offspring of women with coarctation. [8]", "Urgently evaluate chest, back, or neurologic symptoms in pregnancy or postpartum when aneurysm or hypertension is present because aortic complications cluster in the third trimester and postpartum period. [9]" ], "subsections": [], "table": { "caption": "Pregnancy actions for women with coarctation. [3][8][9]", "columns": [ "Time point", "Assessment or action", "Escalation threshold" ], "rows": [ [ "Preconception", "Baseline echocardiography for bicuspid valve, MRA of aorta and brain, and assessment for residual obstruction and hypertension. [9]", "Repair residual/recurrent coarctation when feasible; consider repair of an aortic aneurysm greater than 5.0 cm before pregnancy. [9]" ], [ "Antepartum", "Close blood-pressure monitoring; consider aspirin 81 mg daily from the second trimester. [9]", "Consider serial noncontrast MRA when aortic diameter exceeds 4.0 cm. [9]" ], [ "Delivery", "Vaginal delivery generally preferred with epidural analgesia. [9]", "Consider cesarean delivery for ascending aortic aneurysm greater than 5.0 cm or acute aortic syndrome. [9]" ], [ "Postpartum", "Continue close blood-pressure surveillance. [9]", "Blood pressure is expected to peak on postpartum days 3 through 8. [9]" ] ] } } ], "faq": [], "references": [ { "number": 1, "title": "Aortic coarctation - Symptoms, diagnosis and treatment | BMJ Best Practice US", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-us/698", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com" }, { "number": 2, "title": "Aortic coarctation - Symptoms, diagnosis and treatment | BMJ Best Practice", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-gb/698", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com" }, { "number": 3, "title": "Pregnancy outcomes in women with aortic coarctation - Heart", "detail": "heart.bmj.com", "url": "https://heart.bmj.com/content/heartjnl/early/2020/10/29/heartjnl-2020-317513.full.pdf", "authors": "heart.bmj.com", "host": "heart.bmj.com" }, { "number": 4, "title": "Long-term outcomes in coarctation of the aorta: an evolving story of success and new challenges | Heart", "detail": "heart.bmj.com", "url": "https://heart.bmj.com/content/101/15/1173", "authors": "heart.bmj.com", "host": "heart.bmj.com" }, { "number": 5, "title": "Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease | Heart", "detail": "heart.bmj.com", "url": "https://heart.bmj.com/content/107/21/1704", "authors": "heart.bmj.com", "host": "heart.bmj.com" }, { "number": 6, "title": "Balloon Angioplasty for Native Aortic Coarctation in 3- to 12-Month-Old Infants", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.120.008938", "authors": "www.ahajournals.org", "host": "www.ahajournals.org" }, { "number": 7, "title": "Comparison of Surgical, Stent, and Balloon Angioplasty Treatment of Native Coarctation of the Aorta: An Observational Study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)", "detail": "www.jacc.org", "url": "https://www.jacc.org/doi/10.1016/j.jacc.2011.08.053", "authors": "www.jacc.org", "host": "www.jacc.org" }, { "number": 8, "title": "Coarctation of the aorta: outcome of pregnancy - 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Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "Aortic coarctation - Symptoms, diagnosis and treatment | BMJ Best Practice US", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-us/698", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com", "snippet": "Baumgartner H, De Backer J, Babu-Narayan SV, et al. 2020 ESC guidelines for the management of adult congenital heart disease. Eur Heart J. 2020 Aug 29;ehaa554.Full text\n\nStout KK, Daniels CJ, Aboulhosn JA, et al. 2018 AHA/ACC Guideline for the management of adults with congenital heart disease: a re", "score": 0.81979275 }, { "number": 2, "title": "Aortic coarctation - Symptoms, diagnosis and treatment | BMJ Best Practice", "detail": "bestpractice.bmj.com", "url": "https://bestpractice.bmj.com/topics/en-gb/698", "authors": "bestpractice.bmj.com", "host": "bestpractice.bmj.com", "snippet": "Baumgartner H, De Backer J, Babu-Narayan SV, et al. 2020 ESC guidelines for the management of adult congenital heart disease. Eur Heart J. 2020 Aug 29;ehaa554.Full text\n\nStout KK, Daniels CJ, Aboulhosn JA, et al. 2018 AHA/ACC Guideline for the management of adults with congenital heart disease: a re", "score": 0.80698997 }, { "number": 3, "title": "Pregnancy outcomes in women with aortic coarctation - Heart", "detail": "heart.bmj.com", "url": "https://heart.bmj.com/content/heartjnl/early/2020/10/29/heartjnl-2020-317513.full.pdf", "authors": "heart.bmj.com", "host": "heart.bmj.com", "snippet": "INTRODUCTION Contemporary cohorts of patients with repaired aortic coarctation (CoA) have good long-­ term survival but relatively high cardiac complication rates, including re-­ coarctation in 34%, aortic aneu-rysms in 18%, hypertension in 32% and 13-­ fold increased risk for ischaemic stroke as co", "score": 0.8351749 }, { "number": 4, "title": "Long-term outcomes in coarctation of the aorta: an evolving story of success and new challenges | Heart", "detail": "heart.bmj.com", "url": "https://heart.bmj.com/content/101/15/1173", "authors": "heart.bmj.com", "host": "heart.bmj.com", "snippet": "* Long-term outcomes in coarctation of the aorta: an evolving story of success and new challenges. Long-term outcomes in coarctation of the aorta: an evolving story of success and new challenges. 1. Department of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA. 1. Corresponden", "score": 0.8306082 }, { "number": 5, "title": "Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease | Heart", "detail": "heart.bmj.com", "url": "https://heart.bmj.com/content/107/21/1704", "authors": "heart.bmj.com", "host": "heart.bmj.com", "snippet": "Data obtained from the GenTAC registry on MFS show a significantly higher aortic dissection rate of 5.4 per 100 person‐years during pregnancy and the postpartum period compared with a non-pregnancy dissection rate of 0.6 per 100 patient‐years.3 However, data on the immediate and long-term effects of", "score": 0.6999322 }, { "number": 6, "title": "Balloon Angioplasty for Native Aortic Coarctation in 3- to 12-Month-Old Infants", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.120.008938", "authors": "www.ahajournals.org", "host": "www.ahajournals.org", "snippet": "Balloon angioplasty of native CoA is effective and safe in infants aged 3 to 12 months with outcomes comparable to those in older children and adults. Balloon angioplasty of native and recurrent coarctation of the aorta (CoA) is an established treatment in children and adults, with efficacy comparab", "score": 0.79041743 }, { "number": 7, "title": "Comparison of Surgical, Stent, and Balloon Angioplasty Treatment of Native Coarctation of the Aorta: An Observational Study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)", "detail": "www.jacc.org", "url": "https://www.jacc.org/doi/10.1016/j.jacc.2011.08.053", "authors": "www.jacc.org", "host": "www.jacc.org", "snippet": "Title: Comparison of Surgical, Stent, and Balloon Angioplasty Treatment of Native Coarctation of the Aorta: An Observational Study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)\nAuthors: Thomas J.Forbes, MDtforbes@dmc.org, Dennis W.Kim, MD, PhD, Wei Du, PhD, Daniel R.Turner", "score": 0.73778254 }, { "number": 8, "title": "Coarctation of the aorta: outcome of pregnancy - JACC", "detail": "www.jacc.org", "url": "https://www.jacc.org/doi/abs/10.1016/s0735-1097%2801%2901617-5", "authors": "www.jacc.org", "host": "www.jacc.org", "snippet": "Fifty women with coarctation had pregnancies: Of the 109 offspring, 4 (4%) had congenital heart disease. Nineteen women (38%) were known to have", "score": 0.6562404 }, { "number": 9, "title": "Management of Women With Congenital or Inherited Cardiovascular Disease From Pre-Conception Through Pregnancy and Postpartum: JACC Focus Seminar 2/5", "detail": "www.jacc.org", "url": "https://www.jacc.org/doi/10.1016/j.jacc.2021.02.026", "authors": "www.jacc.org", "host": "www.jacc.org", "snippet": "| Coarctation of the aorta | II–III | Hypertensive disorders of pregnancy (30%), aortic dissection if aneurysm present | Baseline MRA | Consider aspirin 81 mg daily beginning in the second trimester given increased risk of pre-eclampsia | Epidural recommended | Vaginal generally preferred | High ris", "score": 0.6479992 }, { "number": 10, "title": "Management of Severe Coarctation of the Aorta During Pregnancy", "detail": "www.jacc.org", "url": "https://www.jacc.org/doi/10.1016/j.jaccas.2019.11.060", "authors": "www.jacc.org", "host": "www.jacc.org", "snippet": "Mothers with congenital heart disease, such as COA, have an increased risk of having children with congenital heart disease (6).", "score": 0.61112726 }, { "number": 11, "title": "Coarctation of the aorta in adolescents and adults: A review of clinical features and CT imaging - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/pii/S1934592515300162", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Title: Coarctation of the aorta in adolescents and adults: A review of clinical features and CT imaging - ScienceDirect\n# Review article Coarctation of the aorta in adolescents and adults: A review of clinical features and CT imaging. Coarctation of the aorta (CoA), while usually identified and trea", "score": 0.86080295 }, { "number": 12, "title": "On-treatment blood pressure and cardiovascular mortality in adults with repaired coarctation of aorta - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0002870322002034", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "### J Am Coll Cardiol\n\n### Potential benefits of ambulatory blood pressure monitoring in coarctation of aorta\n\n### J Am Coll Cardiol\n\n### Masked hypertension and cardiovascular outcomes: an updated systematic review and meta-analysis\n\n### Integr Blood Press Control\n\n### Pulsatile arterial haemodynam", "score": 0.7368747 }, { "number": 13, "title": "Aortic Coarctation - an overview | ScienceDirect Topics", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/aortic-coarctation", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Clinically detectable CoA in the adult, with a resting gradient of 20 mm Hg or more between upper and lower extremities, carries an increasing risk of progressive LV dysfunction, persistent systemic arterial systolic hypertension, and premature cerebrovascular and coronary atherosclerosis, and the p", "score": 0.76173395 }, { "number": 14, "title": "MRI in adult patients with aortic coarctation: diagnosis and follow-up - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0009926014005467", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "cMRI, along with gadolinium-enhanced magnetic resonance angiography, provides excellent resolution of cardiac anatomy and vascular structures (Fig. 4). Additionally, phase contrast flow analysis can be used to estimate flow and peak gradient through the coarctation.26 Compared with echocardiography,", "score": 0.6912478 }, { "number": 15, "title": "Echocardiography in Planning Aortic Arch Interventions - Ovid", "detail": "journals.lww.com", "url": "https://journals.lww.com/jiae/fulltext/2022/06030/echocardiography_in_planning_aortic_arch.8.aspx", "authors": "journals.lww.com", "host": "journals.lww.com", "snippet": "Echocardiography is particularly diagnostic in the pediatric population, for the most frequently encountered arch disease – coarctation of the aorta.", "score": 0.54594 }, { "number": 16, "title": "Current management of coarctation of the aorta", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4710863", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "## guidelines for adults with congenital heart disease recommended intervention for coarctation in the following settings3:Peak-to-peak coarctation gradient ≥20 mg; which is the difference in peak pressure proximal and beyond the narrowed segment.Peak-to-peak coarctation gradient <20 mg with imagin", "score": 0.8364614 }, { "number": 17, "title": "Management of Coarctation of The Aorta in Adult Patients: State of The Art", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6428953", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "14.Stout KK, Daniels CJ, Aboulhosn JA, _et al_. 2018 AHA/ACC guideline for the management of adults with congenital heart disease. _J Am Coll Cardiol_. 2018. doi: 10.1016/j.jacc.2018.08.1029 [DOI] [PubMed] [Google Scholar]\n 15.Baumgartner H, Bonhoeffer P, De Groot NM, _et al_. ESC guidelines for t", "score": 0.83452857 }, { "number": 18, "title": "Clinical Practice Algorithm For the Follow-Up of Repaired Coarctation of the Aorta - American College of Cardiology", "detail": "www.acc.org", "url": "https://www.acc.org/Latest-in-Cardiology/Articles/2023/02/16/17/09/Clinical-Practice-Algorithm-For-the-Follow-Up-of-Repaired-Coarctation-of-the-Aorta", "authors": "www.acc.org", "host": "www.acc.org", "snippet": "Title: Clinical Practice Algorithm For the Follow-Up of Repaired Coarctation of the Aorta - American College of Cardiology\nThe goal of the congenital heart disease (CHD) Clinical Practice Algorithm for Repaired CoA is to provide an age-based decision-support tool that can be used in the follow-up an", "score": 0.82048416 }, { "number": 19, "title": "Surgical repair of aortic coarctation in adults: half a century of a single centre clinical experience - PMC", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7043140", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "After repair of aortic coarctation, patients may develop restenosis, aneurysms and pseudo-aneurysms at the site of prior repair . In our series no late aneurysm formation at the site of repair occurred. Therapy of either restenosis or (pseudo)aneurysm may consist of surgery, balloon angioplasty or s", "score": 0.81418616 }, { "number": 20, "title": "Coarctation of the aorta in adults: what is the best treatment? Case report and literature review", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3124275", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "The 2008 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for adults with congenital heart disease (ACHD), recommend intervention for coarctation in the following circumstances : peak to peak coarctation gradient greater than or equal to 20 mmHg, or peak to peak coarcta", "score": 0.81133276 }, { "number": 21, "title": "Catheter Management of Coarctation - StatPearls - NCBI Bookshelf", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/books/NBK560812", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "The process of deciding which patients are appropriate for endovascular repair of aortic coarctation is challenging. This depends on numerous factors, including the patient's age, the presence of concomitant congenital heart defects, and the specific anatomy of the coarcted segment. As such, appropr", "score": 0.72675586 }, { "number": 22, "title": "Management of Recurrent Coarctation in Children - American College of Cardiology", "detail": "www.acc.org", "url": "https://www.acc.org/latest-in-cardiology/articles/2025/07/02/15/19/management-of-recurrent-coarctation-in-children", "authors": "www.acc.org", "host": "www.acc.org", "snippet": "5. Salciccioli KB, Zachariah JP. Coarctation of the aorta: modern paradigms across the lifespan. Hypertension. 2023;80(10):1970-1979. doi:10.1161/HYPERTENSIONAHA.123.19454\n6. Makhoul M, Markush, D, Baker-Smith CM, et al. Clinical practice algorithm for the follow-up of repaired coarctation of the ao", "score": 0.6922474 }, { "number": 23, "title": "2 The procedure | Balloon angioplasty with or without stenting for coarctation or recoarctation of the aorta in adults and children | Guidance | NICE", "detail": "www.nice.org.uk", "url": "https://www.nice.org.uk/guidance/HTG45/chapter/2-the-procedure", "authors": "www.nice.org.uk", "host": "www.nice.org.uk", "snippet": "### 2.4 Safety\n\n#### 2.4.1\n\nIn the RCT, the main complications reported were: aneurysm in 20% (4 out of 20) of the angioplasty group and 0% (0 out of 16) of the surgery group; diminished pulse (in the leg through which angioplasty was performed) in 10% (2 out of 20) of the angioplasty group and 0% (", "score": 0.7837407 }, { "number": 24, "title": "Current management of coarctation of the aorta - PMC", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710863", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "Title: Current management of coarctation of the aorta - PMC\nFurthermore, recurrent coarctation and future aneurysm formation can occur following successful surgical and endovascular repair which mandates long-term close surveillance. Recoarctation is an important long-term complication resulting due", "score": 0.7309246 } ], "publishedAt": "2026-09-15T22:40:33.285861+00:00", "updatedAt": "2026-09-15T22:40:33.285861+00:00", "readingMinutes": 6, "slug": "coarctation-of-the-aorta" }