{ "schemaVersion": 2, "eyebrow": "Gastroenterology", "title": "Acute Pancreatitis", "summary": "Acute pancreatitis requires rapid confirmation, severity assessment, etiologic evaluation, and targeted supportive care. The supplied search results do not include pancreatitis-specific diagnostic criteria, fluid protocols, nutrition guidance, biliary intervention recommendations, or antimicrobial indications; management details therefore require verification against current specialty guidance.", "seoDescription": "Point-of-care overview of acute pancreatitis emphasizing diagnostic confirmation, severity assessment, etiologic evaluation, and evidence gaps requiring current guideline review.", "clinicalQuestion": "How should physicians confirm acute pancreatitis, stratify severity, identify cause, and prioritize early management?", "specialty": "Gastroenterology", "audience": "U.S. physicians and medical trainees", "tags": [ "acute pancreatitis", "pancreatitis diagnosis", "pancreatitis severity", "etiologic evaluation", "supportive care" ], "keyTakeaways": [ "The supplied evidence does not provide pancreatitis-specific criteria or treatment recommendations; avoid substituting evidence from unrelated diagnostic, cardiovascular, or pharmacologic sources.", "If acute pancreatitis occurs during sitagliptin therapy, the FDA label advises prompt discontinuation when pancreatitis is suspected and initiation of appropriate management. [3]", "TriVerity is a host-response assay studied in emergency patients with suspected infection or sepsis; it does not establish or exclude acute pancreatitis. [8]" ], "sections": [ { "id": "scope-and-evidence", "eyebrow": "Evidence boundary", "heading": "What the supplied evidence supports", "intro": "The search set is not a pancreatitis management evidence base.", "paragraphs": [ "No supplied result provides acute-pancreatitis-specific diagnostic thresholds, severity classification, recommended initial fluid strategy, analgesic regimen, enteral feeding timing, imaging sequence, indications for ERCP, antibiotic criteria, or criteria for drainage or necrosectomy. Accordingly, these decisions should be verified in current pancreatitis-focused U.S. professional guidance and local pathways before use at the bedside.", "The only directly relevant supplied source is the sitagliptin prescribing information, which reports postmarketing acute pancreatitis, including fatal and nonfatal hemorrhagic or necrotizing cases. It instructs clinicians to discontinue sitagliptin promptly if pancreatitis is suspected and initiate appropriate management. Whether a history of pancreatitis increases risk during sitagliptin therapy is unknown. [3]" ], "bullets": [ "Do not infer acute pancreatitis diagnosis from host-response molecular testing designed for suspected infection or sepsis. [8]", "Do not use this source set to select intravenous fluid type, volume, rate, antibiotic therapy, nutritional route, ERCP timing, or procedural intervention.", "Medication reconciliation is clinically relevant when pancreatitis is suspected, particularly for sitagliptin exposure. [3]" ], "subsections": [], "table": { "caption": "Supplied-source applicability to acute pancreatitis decisions", "columns": [ "Clinical decision", "Evidence available in supplied results", "Point-of-care implication" ], "rows": [ [ "Confirm acute pancreatitis", "No pancreatitis-specific diagnostic criteria or laboratory thresholds supplied.", "Use current specialty guidance; do not derive criteria from these results." ], [ "Assess severity or predict complications", "TriVerity predicted need for mechanical ventilation, vasopressors, and/or new renal replacement therapy within 7 days among ED patients with suspected infection or sepsis; it was not validated for pancreatitis-specific severity assessment. [8]", "Do not substitute this assay for pancreatitis-specific risk stratification." ], [ "Review possible medication contribution", "Sitagliptin labeling includes postmarketing reports of acute pancreatitis and directs prompt discontinuation if suspected. [3]", "Hold sitagliptin when pancreatitis is suspected; evaluate alternative causes concurrently." ], [ "Initial treatment and interventions", "No directly applicable pancreatitis treatment evidence supplied.", "Verify current gastroenterology, surgery, and critical care recommendations." ] ] } }, { "id": "medication-safety", "eyebrow": "Medication review", "heading": "Sitagliptin when pancreatitis is suspected", "intro": "This is the only pancreatitis-specific action supported by the supplied literature.", "paragraphs": [ "Sitagliptin is a dipeptidyl peptidase-4 inhibitor indicated to improve glycemic control in adults with type 2 diabetes. Its FDA labeling describes postmarketing reports of acute pancreatitis, including hemorrhagic and necrotizing pancreatitis. If pancreatitis is suspected after initiation or during treatment, stop sitagliptin promptly and manage the patient appropriately. [3]", "The label states that sitagliptin has not been studied in patients with a history of pancreatitis and that it is unknown whether such patients have increased risk while receiving the drug. This is a knowledge gap rather than a quantified contraindication. [3]" ], "bullets": [ "Document exposure timing, dose, renal function, concomitant glucose-lowering drugs, alcohol exposure, biliary history, triglyceride status, and other plausible etiologies; the supplied evidence does not permit attribution of causality to sitagliptin alone.", "Reassess the antihyperglycemic regimen after sitagliptin discontinuation. The supplied label supports renal-function-based sitagliptin dose adjustment but does not provide an acute-pancreatitis-specific replacement strategy. [3]", "Sitagliptin monotherapy has low observed hypoglycemia incidence in pooled trials, but hypoglycemia increases when used with insulin or a sulfonylurea; if those agents are continued during acute illness, reassess dosing and glycemic monitoring. [3]" ], "subsections": [], "table": { "caption": "Sitagliptin label information relevant to suspected acute pancreatitis [3]", "columns": [ "Issue", "Label-supported information", "Action" ], "rows": [ [ "Suspected pancreatitis", "Postmarketing acute pancreatitis, including fatal and nonfatal hemorrhagic or necrotizing pancreatitis, has been reported. [3]", "Promptly discontinue sitagliptin and initiate appropriate management. [3]" ], [ "Prior pancreatitis", "Not studied; whether prior pancreatitis increases risk is unknown. [3]", "Use individualized risk-benefit assessment; seek current diabetes and pancreatitis guidance." ], [ "Renal function", "The label recommends assessment before starting and periodically thereafter; dose reduction is specified for moderate or severe renal impairment and ESRD. [3]", "Review renal function during acute illness, but do not infer pancreatitis treatment from renal dose tables." ] ] } }, { "id": "avoid-misapplication", "eyebrow": "Diagnostic stewardship", "heading": "Avoid misapplying sepsis biomarkers to pancreatitis", "intro": "Inflammatory presentations overlap clinically but not diagnostically.", "paragraphs": [ "A prospective validation study evaluated the FDA-cleared TriVerity host-response assay in adults presenting to emergency departments with suspected acute infection or sepsis. The assay generates bacterial, viral, and severity scores from expression of 29 host-response mRNAs and was evaluated against adjudicated infection status and a composite of mechanical ventilation, vasopressor use, or new renal replacement therapy within 7 days. [8]", "Acute pancreatitis may produce systemic inflammation and organ dysfunction, but the supplied study did not validate TriVerity for diagnosing pancreatitis, distinguishing sterile pancreatic inflammation from pancreatitis-related infection, or guiding pancreatitis-specific treatment. A high severity score should not be interpreted as proof of pancreatitis severity, and a low bacterial score should not be used to decide against evaluation for infected pancreatic necrosis or another source of infection. [8]" ], "bullets": [ "Use host-response test results, if obtained for an independent sepsis evaluation, only within the population and intended clinical context studied. [8]", "A diagnostic test's accuracy depends on its intended use, target population, reference standard, and disease prevalence; extrapolation beyond the validation setting can introduce clinically important error. [10]", "When systemic inflammation accompanies abdominal pain, preserve parallel evaluation for pancreatitis, biliary disease, ischemia, perforation, cholangitis, and infection rather than allowing a single biomarker to collapse the differential diagnosis. The supplied evidence does not provide a validated pathway for this distinction." ], "subsections": [], "table": { "caption": "Limits of applying supplied diagnostic evidence to acute pancreatitis", "columns": [ "Test or framework", "Studied purpose", "Not established for acute pancreatitis" ], "rows": [ [ "TriVerity [8]", "Likelihood of bacterial infection, viral infection, and need for specified critical-care interventions within 7 days in adults with suspected infection or sepsis. [8]", "Diagnosis of pancreatitis; pancreatitis etiology; pancreatic necrosis; infected necrosis; need for ERCP, drainage, or surgery." ], [ "Diagnostic-test evaluation framework [10]", "Methodologic principles for test development and evaluation during emerging infectious disease outbreaks. [10]", "A pancreatitis diagnostic or management algorithm." ] ] } } ], "faq": [ { "question": "Should sitagliptin be continued when acute pancreatitis is suspected?", "answer": "No. The sitagliptin label directs prompt discontinuation if pancreatitis is suspected and initiation of appropriate management. [3]" }, { "question": "Does a history of pancreatitis contraindicate sitagliptin?", "answer": "The supplied FDA labeling states that sitagliptin has not been studied in patients with prior pancreatitis and that any increased risk in this group is unknown. [3]" }, { "question": "Can TriVerity confirm or exclude acute pancreatitis?", "answer": "No. The supplied validation study concerns bacterial and viral infection likelihood and short-term critical-care needs in suspected infection or sepsis, not pancreatitis diagnosis or severity. [8]" }, { "question": "What pancreatitis-specific treatment protocol can be derived from these sources?", "answer": "None. The supplied results lack direct evidence for diagnostic criteria, fluid resuscitation, analgesia, nutrition, antibiotics, ERCP, drainage, or necrosectomy in acute pancreatitis." } ], "references": [ { "number": 1, "title": "highlights of prescribing information", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f818ffe0-43df-4cc6-bc86-00b2c79b06fc&type=display", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov" }, { "number": 2, "title": "These highlights do not include all the information needed to use colchicine safely and effectively. See full prescribing information for Colchicine Tablets, USP. \n Colchicine Tablets, USP, for oral use Initial U.S. Approval: 1961", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fc439ae8-a79e-4942-8d02-22422b19b015&type=display", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov" }, { "number": 3, "title": "These highlights do not include all the information needed to use JANUVIA safely and effectively. See full prescribing information for JANUVIA.\n JANUVIA® (sitagliptin) TabletsInitial U.S. Approval: 2006", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=aaadccea-4842-493b-a0bd-0ee7645fc250", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov" }, { "number": 4, "title": "These highlights do not include all the information needed to use KERENDIA safely and effectively. See full prescribing information for KERENDIA. \n KERENDIA (finerenone) tablets, for oral use Initial U.S. Approval: 2021", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fc726765-5d5a-4d6e-b037-b847bda9fb7c&type=display", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov" }, { "number": 5, "title": "2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/ ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001415", "authors": "www.ahajournals.org", "host": "www.ahajournals.org" }, { "number": 6, "title": "2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/ ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251", "authors": "www.ahajournals.org", "host": "www.ahajournals.org" }, { "number": 7, "title": "2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356", "authors": "www.ahajournals.org", "host": "www.ahajournals.org" }, { "number": 8, "title": "Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis | Nature Medicine", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41591-025-03933-y", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 9, "title": "Development and validation of prognostic machine learning models for short- and long-term mortality among acutely admitted patients based on blood tests | Scientific Reports", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41598-024-56638-6", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 10, "title": "A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s43856-024-00691-9", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 11, "title": "The hidden risk of round numbers and sharp thresholds in clinical practice | npj Digital Medicine", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41746-025-02079-y", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 12, "title": "ACC/AHA Guidelines for the Management of Patients With ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/01.cir.94.9.2341", "authors": "www.ahajournals.org", "host": "www.ahajournals.org" }, { "number": 13, "title": "A scoping review of evidence-based guidance and guidelines ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/fampra/article/41/4/404/7051177", "authors": "academic.oup.com", "host": "academic.oup.com" }, { "number": 14, "title": "Clinician Testing and Treatment Thresholds for Management ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/ofid/article/10/9/ofad455/7256803", "authors": "academic.oup.com", "host": "academic.oup.com" }, { "number": 15, "title": "Diagnostic testing and the evolution of detection avoidance by ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/emph/article/12/1/248/7742490", "authors": "academic.oup.com", "host": "academic.oup.com" }, { "number": 16, "title": "Impact of Individualized Versus Weight-Based Pain ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0099176724003799", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 17, "title": "Implementing ASH's guidelines for acute medical care ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/pii/S2473952925001132", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 18, "title": "Acute Pain Management - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/nursing-and-health-professions/acute-pain-management", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 19, "title": "Monitoring Procedure - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/monitoring-procedure", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com" }, { "number": 20, "title": "Clinical Practice Guidelines Development: Training and Resources", "detail": "www.idsociety.org", "url": "https://www.idsociety.org/clinical-practice-guidelines-development-training-and-resources", "authors": "www.idsociety.org", "host": "www.idsociety.org" }, { "number": 21, "title": "Code and Guideline Changes | AMA", "detail": "www.acc.org", "url": "https://www.acc.org/-/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/Latest%20in%20Cardiology/Advocacy%20and%20Policy/2021-AMA-EM-clarificatons-030921", "authors": "www.acc.org", "host": "www.acc.org" }, { "number": 22, "title": "All Practice Guidelines: A-Z List", "detail": "www.idsociety.org", "url": "https://www.idsociety.org/idsa_practice_guidelines", "authors": "www.idsociety.org", "host": "www.idsociety.org" }, { "number": 23, "title": "Policy Statements", "detail": "www.annemergmed.com", "url": "https://www.annemergmed.com/article/S0196-0644(24)01070-9/fulltext", "authors": "www.annemergmed.com", "host": "www.annemergmed.com" }, { "number": 24, "title": "Practice Guidelines", "detail": "www.aasld.org", "url": "https://www.aasld.org/practice-guidelines", "authors": "www.aasld.org", "host": "www.aasld.org" } ], "editorialNote": "Prepared from cited clinical literature using Astra's research workflow. Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "highlights of prescribing information", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f818ffe0-43df-4cc6-bc86-00b2c79b06fc&type=display", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov", "snippet": "In the presence of mild to moderate renal or hepatic impairment, adjustment of dosing is not required for treatment of FMF, but patients should be monitored", "score": 0.64880073 }, { "number": 2, "title": "These highlights do not include all the information needed to use colchicine safely and effectively. See full prescribing information for Colchicine Tablets, USP. \n Colchicine Tablets, USP, for oral use Initial U.S. Approval: 1961", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fc439ae8-a79e-4942-8d02-22422b19b015&type=display", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov", "snippet": "| | HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use colchicine safely and effectively. See full prescribing information for Colchicine Tablets, USP. Colchicine Tablets, USP, for oral use Initial U.S. Approval: 1961 INDICATIONS AND USAGE", "score": 0.41151342 }, { "number": 3, "title": "These highlights do not include all the information needed to use JANUVIA safely and effectively. See full prescribing information for JANUVIA.\n JANUVIA® (sitagliptin) TabletsInitial U.S. Approval: 2006", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=aaadccea-4842-493b-a0bd-0ee7645fc250", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov", "snippet": "mL/min ~Serum Cr levels [mg/dL] Men: >1.7–≤3.0; Women: >1.5–≤2.5 | Severe and ESRD CrCl <30 mL/min ~Serum Cr levels [mg/dL] Men: >3.0; Women: >2.5; or on dialysis | DOSAGE FORMS AND STRENGTHS Tablets: 100 mg, 50 mg, and 25 mg (3) CONTRAINDICATIONS History of a serious hypersensitivity react", "score": 0.26867542 }, { "number": 4, "title": "These highlights do not include all the information needed to use KERENDIA safely and effectively. See full prescribing information for KERENDIA. \n KERENDIA (finerenone) tablets, for oral use Initial U.S. Approval: 2021", "detail": "dailymed.nlm.nih.gov", "url": "https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fc726765-5d5a-4d6e-b037-b847bda9fb7c&type=display", "authors": "dailymed.nlm.nih.gov", "host": "dailymed.nlm.nih.gov", "snippet": "Table 1: Recommended Starting Dosage\n\n| eGFR (mL/min/1.73m2) | Starting Dose |\n --- |\n| ≥ 60 | 20 mg orally once daily |\n| ≥ 25 to < 60 | 10 mg orally once daily |\n| < 25 | Initiation is not recommended |\n\nFor patients who are unable to swallow whole tablets, Kerendia may be crushed and mixed with w", "score": 0.2504913 }, { "number": 5, "title": "2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/ ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001415", "authors": "www.ahajournals.org", "host": "www.ahajournals.org", "snippet": "Feb 19, 2026 — The focus of this clinical practice guideline is the evaluation and management of acute pulmonary embolism (PE) in the adult patient (≥18 years", "score": 0.42448413 }, { "number": 6, "title": "2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/ ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251", "authors": "www.ahajournals.org", "host": "www.ahajournals.org", "snippet": "by HL Gornik · 2024 · Cited by 1002 — provides recommendations to guide clinicians in the treatment of patients with lower extremity peripheral artery disease … s approved for", "score": 0.061927155 }, { "number": 7, "title": "2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356", "authors": "www.ahajournals.org", "host": "www.ahajournals.org", "snippet": "by Writing Committee Members* · 2025 · Cited by 773 — The term guideline-directed medical therapy (GDMT) encompasses clinical evaluation, diagnostic testing, and both pharmacological and procedural treatments.", "score": 0.05720304 }, { "number": 8, "title": "Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis | Nature Medicine", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41591-025-03933-y", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Taylor et al.23.\") recently surveyed 153 US clinicians responding to real-world derived vignettes of suspected sepsis to analyze decision thresholds to treat or not with antibiotics, using infection prediction models and varying case severities. Although the overall threshold to treat was 69% probab", "score": 0.6396691 }, { "number": 9, "title": "Development and validation of prognostic machine learning models for short- and long-term mortality among acutely admitted patients based on blood tests | Scientific Reports", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41598-024-56638-6", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "value, and negative predictive value for the complete data, based on probability threshold of 0.5, were estimated for the training and test data and evaluated between them. Similarly, analyses were performed on the top ML models, including a sensitivity analysis using data without variable imputatio", "score": 0.5843666 }, { "number": 10, "title": "A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s43856-024-00691-9", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Joint data collection and sharing infrastructure can be used to make infected samples available to test developers.\n\nThreshold selection for diagnostic tests must be done in advance, but the optimal threshold depends on ever-changing disease prevalences and consequences of misclassification.\n\n A l", "score": 0.28234753 }, { "number": 11, "title": "The hidden risk of round numbers and sharp thresholds in clinical practice | npj Digital Medicine", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41746-025-02079-y", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Clinical practice requires consistency of application and ease of implementation. Based on these requirements, guidelines for clinical practice are often presented as round-number thresholds to facilitate uniform decision-making. For example, both the Acute Physiology and Chronic Health Evaluation (", "score": 0.2117756 }, { "number": 12, "title": "ACC/AHA Guidelines for the Management of Patients With ...", "detail": "www.ahajournals.org", "url": "https://www.ahajournals.org/doi/10.1161/01.cir.94.9.2341", "authors": "www.ahajournals.org", "host": "www.ahajournals.org", "snippet": "by TJ Ryan · 1996 · Cited by 426 — These guidelines are intended for physicians, nurses, and allied healthcare personnel who care for patients with suspected or established acute myocardial", "score": 0.35952207 }, { "number": 13, "title": "A scoping review of evidence-based guidance and guidelines ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/fampra/article/41/4/404/7051177", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "by E O’Brien · 2024 · Cited by 8 — Studies were included if they were: (i) evidence-based guidance documents or clinical guidelines produced de novo by a national GP professional", "score": 0.15980688 }, { "number": 14, "title": "Clinician Testing and Treatment Thresholds for Management ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/ofid/article/10/9/ofad455/7256803", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "by A Harris · 2023 · Cited by 3 — The threshold model describes a probability of disease at which a clinician will test for the disease, and a higher probability at which a clinician will treat", "score": 0.23530203 }, { "number": 15, "title": "Diagnostic testing and the evolution of detection avoidance by ...", "detail": "academic.oup.com", "url": "https://academic.oup.com/emph/article/12/1/248/7742490", "authors": "academic.oup.com", "host": "academic.oup.com", "snippet": "by J Wood · 2024 · Cited by 1 — We derive key thresholds under which a testing regime will (i) select for diagnostic test avoidance, or (ii) drive the pathogen extinct.", "score": 0.23312138 }, { "number": 16, "title": "Impact of Individualized Versus Weight-Based Pain ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0099176724003799", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "by SO Ibemere · 2025 · Cited by 1 — National guidelines for the acute management of sickle cell disease vaso-occlusive episodes recommend the use of a patient-specific or a weight-based protocol.", "score": 0.43208793 }, { "number": 17, "title": "Implementing ASH's guidelines for acute medical care ...", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/pii/S2473952925001132", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "by MR DeBaun · 2025 · Cited by 3 — The ASH special panel's recommendations for management of acute neurological deficits in incarcerated children and adults with SCD. The ASH", "score": 0.29979196 }, { "number": 18, "title": "Acute Pain Management - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/nursing-and-health-professions/acute-pain-management", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Standardized protocols include the assessment and charting of pain scores as the fifth vital sign. Patients with high pain intensity scores (>5 on a 10-point", "score": 0.23480159 }, { "number": 19, "title": "Monitoring Procedure - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/monitoring-procedure", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Criteria usually include measurements of time, temperature, moisture level, water activity, available chlorine or sensory parameters", "score": 0.15217108 }, { "number": 20, "title": "Clinical Practice Guidelines Development: Training and Resources", "detail": "www.idsociety.org", "url": "https://www.idsociety.org/clinical-practice-guidelines-development-training-and-resources", "authors": "www.idsociety.org", "host": "www.idsociety.org", "snippet": "The following resources represent the various background and critical appraisal tools used for guidelines development. \n \nInstitute of Medicine (IOM): Standards for Developing Trustworthy Clinical Practice Guidelines \nWhen treating patients, doctors and other healthcare providers are often faced", "score": 0.22779596 }, { "number": 21, "title": "Code and Guideline Changes | AMA", "detail": "www.acc.org", "url": "https://www.acc.org/-/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/Latest%20in%20Cardiology/Advocacy%20and%20Policy/2021-AMA-EM-clarificatons-030921", "authors": "www.acc.org", "host": "www.acc.org", "snippet": "consideration of hospital level of care. Undiagnosed new problem with uncertain prognosis: A problem in the differential diagnosis that represents a condition likely to result in a high risk of morbidity without treatment. An example may be a lump in the breast. Acute illness with systemic symptoms:", "score": 0.22357234 }, { "number": 22, "title": "All Practice Guidelines: A-Z List", "detail": "www.idsociety.org", "url": "https://www.idsociety.org/idsa_practice_guidelines", "authors": "www.idsociety.org", "host": "www.idsociety.org", "snippet": "IDSA clinical guidance documents are developed based on a comprehensive (but not necessarily systematic) review of the available evidence, coupled with experience of clinical and research experts on the topic. They do not include a formal grading of the evidence. Over time, IDSA guidance documents m", "score": 0.21143347 }, { "number": 23, "title": "Policy Statements", "detail": "www.annemergmed.com", "url": "https://www.annemergmed.com/article/S0196-0644(24)01070-9/fulltext", "authors": "www.annemergmed.com", "host": "www.annemergmed.com", "snippet": "by PS CENTERS · 2025 — Clinical standards of care developed, established, and promulgated by EMS physician medical directors, in the form of clinical care guidelines or protocols,", "score": 0.20924373 }, { "number": 24, "title": "Practice Guidelines", "detail": "www.aasld.org", "url": "https://www.aasld.org/practice-guidelines", "authors": "www.aasld.org", "host": "www.aasld.org", "snippet": "Learn More\n\n## Guidelines and Guidance by Disease\n\n Acute Liver Failure, Management\n Acute-on-Chronic Liver Failure and the Management\n Alcohol-Associated Liver Disease\n Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome, Management\n Autoimmune Hepatitis, Management\n Drug, Herbal, a", "score": 0.20008872 } ], "publishedAt": "2026-08-20T23:24:56.517137Z", "updatedAt": "2026-08-20T23:24:56.517137Z", "readingMinutes": 3, "slug": "acute-pancreatitis" }