{ "schemaVersion": 2, "eyebrow": "Oral Medicine", "title": "Acute Necrotizing Ulcerative Gingivitis", "summary": "Acute necrotizing ulcerative gingivitis is a clinical diagnosis requiring prompt dental debridement, plaque-control measures, and assessment for immunosuppression or systemic illness. Distinguish papillary necrosis from herpetic, streptococcal, gonococcal, and immune-mediated gingival disease; escalate rapidly when necrosis extends or the host is severely immunocompromised.", "seoDescription": "Point-of-care diagnosis, differential, urgent dental management, antibiotic indications, and escalation for acute necrotizing ulcerative gingivitis.", "clinicalQuestion": "How should physicians recognize, triage, and coordinate treatment for acute necrotizing ulcerative gingivitis?", "specialty": "Oral Medicine", "audience": "U.S. physicians and medical trainees", "tags": [ "acute necrotizing ulcerative gingivitis", "ANUG", "necrotizing gingivitis", "trench mouth", "Vincent infection", "necrotizing periodontal disease" ], "keyTakeaways": [ "Diagnose ANUG clinically when abrupt gingival pain, spontaneous bleeding, and necrosis of interdental papillae occur, often with pseudomembrane formation and halitosis. [16][17][18]", "Arrange urgent dental or periodontal assessment for superficial debridement and local plaque control; microbiologic testing is generally not diagnostically useful, and culture is not recommended routinely. [16][18][21]", "Use systemic antibiotics selectively for systemic illness or immunocompromise, in addition to—not instead of—local debridement and oral-hygiene measures. [7][11][16]", "Evaluate for modifiable and systemic predispositions, particularly HIV, malnutrition, tobacco exposure, poor oral hygiene, psychological stress, and severe immunocompromise. [16][18][24]", "Rapidly progressive necrosis in a neutropenic or otherwise profoundly immunocompromised patient warrants urgent multidisciplinary management because progression to sepsis has been reported. [9]" ], "sections": [ { "id": "recognition-and-triage", "eyebrow": "Initial Decision", "heading": "Recognize the clinical pattern and identify urgent escalation", "intro": "The immediate task is to confirm the characteristic gingival pattern and determine whether local outpatient care is safe.", "paragraphs": [ "Make a presumptive clinical diagnosis when there is acute onset of intense gingival pain, spontaneous bleeding, and punched-out necrosis or ulceration of one or more interdental papillae. A gray pseudomembranous surface, fetid breath, excessive salivation, and regional symptoms support the diagnosis. [1][16][17][18]", "Assess the extent of disease at the first examination. Disease confined to gingiva is consistent with necrotizing gingivitis; tooth loosening, periodontal attachment or osseous involvement, or extension beyond gingiva should prompt urgent dental-periodontal evaluation for more extensive necrotizing periodontal disease or stomatitis. Radiographic bone loss around teeth or implants has been reported with necrotizing ulcerative gingivitis-periodontitis. [12][13][23]", "Escalate urgently when the patient has fever, malaise, lymphadenopathy, rapidly spreading oral necrosis, inability to maintain oral intake, or major host-defense impairment. Children receiving chemotherapy with severe neutropenia and thrombocytopenia can deteriorate rapidly despite local measures and broad-spectrum antibiotics; reported progression included sepsis and death. [7][9]" ], "bullets": [ "Ask specifically about HIV status or testing history, chemotherapy, neutropenia, nutritional compromise, tobacco use, sleep deprivation, severe psychosocial stress, and oral-hygiene access; each is associated with necrotizing gingival disease or susceptibility. [16][18][24]", "Document papillary necrosis, bleeding, pseudomembrane, halitosis, periodontal pocketing, tooth mobility, palate or buccal-mucosal involvement, and cervical lymphadenopathy to establish baseline extent and direct follow-up. [1][12][13][16]", "Coordinate same-day dental evaluation when pain or necrosis prevents adequate self-care, when diagnostic alternatives remain plausible, or when debridement is needed. [7][11][16]" ], "subsections": [], "table": { "caption": "Clinical findings that change urgency and next action. [7][9][12][13][16][23]", "columns": [ "Finding", "Interpretation", "Next action" ], "rows": [ [ "Painful bleeding papillae with focal necrosis and halitosis", "Typical clinical pattern of ANUG. [16][17][18]", "Arrange prompt dental debridement and local antimicrobial oral-care measures. [7][11][16]" ], [ "Tooth loosening, periodontal destruction, or radiographic bone loss", "Suggests extension beyond uncomplicated gingivitis. [12][13][23]", "Urgent periodontal assessment and radiographic evaluation. [23]" ], [ "Fever, malaise, or lymphadenopathy", "Systemic features increase concern for more severe infection and support adjunctive systemic antibiotics. [7]", "Assess host status and arrange urgent dental management; add systemic therapy when clinically indicated. [7][16]" ], [ "Severe neutropenia, thrombocytopenia, or chemotherapy-associated rapid progression", "High-risk host with reported risk of septic deterioration. [9]", "Urgent hospital-based multidisciplinary assessment; tailor procedural and antimicrobial decisions to hematologic status. [9]" ] ] } }, { "id": "diagnosis-and-differential", "eyebrow": "Diagnostic Workup", "heading": "Use examination to separate ANUG from mimics", "intro": "ANUG is primarily a clinical diagnosis; testing is directed by atypical findings, host risk, and concern for an alternate disease.", "paragraphs": [ "The diagnostic triad is rapid onset of gingival pain, interdental papillary necrosis, and bleeding. Pseudomembrane formation and halitosis strengthen the diagnosis, but neither substitutes for careful inspection of the gingival margin and papillae. [16][17][18]", "Do not obtain routine lesion culture to establish ANUG. The lesion microbiota may include Treponema, Selenomonas, Fusobacterium, and Prevotella species, but similar organisms can be detected in healthy and other periodontal sites; therefore microbiologic testing does not provide useful diagnostic discrimination. IDSA/ASM guidance lists Gram stain as a potential diagnostic procedure for Vincent angina but does not recommend culture; if sampling is attempted, use biopsy or irrigation/aspirate rather than a swab. [18][21]", "Pursue an alternate diagnosis when the lesion distribution or associated findings do not fit papillary necrosis. Acute herpetic gingivostomatitis and infectious mononucleosis are important viral mimics; gonococcal and streptococcal gingivitis are bacterial considerations. Desquamative gingivitis, erythema multiforme, and pemphigus vulgaris should enter the differential when diffuse desquamation, broader mucocutaneous involvement, or persistent atypical erosions predominate. [16][18]" ], "bullets": [ "Evaluate periodontal destruction and tooth mobility; their presence changes the working diagnosis from gingivitis alone toward necrotizing periodontitis. [12][13][23]", "Obtain dental radiographs when clinical examination suggests periodontal or periapical pathology, tooth mobility, or extension of tissue destruction; radiographic bone loss supports periodontal involvement. [23]", "In a patient with HIV risk or unknown status, offer diagnostic evaluation for HIV because ANUG is associated with HIV and can occur even when CD4+ counts are stable. [5][16]", "When lesions are atypical, persistent, or clinically suggestive of mucocutaneous disease, direct diagnostic evaluation toward the suspected alternative rather than relying on superficial microbiologic testing. [16][18][21]" ], "subsections": [], "table": { "caption": "Key distinctions among ANUG and common diagnostic alternatives. [16][18][21][23]", "columns": [ "Condition", "Feature favoring the diagnosis", "Practical next step" ], "rows": [ [ "ANUG", "Acute pain, spontaneous bleeding, and interdental papillary necrosis; pseudomembrane and halitosis may be present. [16][17][18]", "Prompt dental debridement and assessment of systemic predispositions. [7][16]" ], [ "Necrotizing periodontitis", "Periodontal destruction, tooth mobility, or radiographic bone loss accompanies necrotizing gingival lesions. [12][13][23]", "Urgent periodontal evaluation and imaging for extent of destruction. [23]" ], [ "Acute herpetic gingivostomatitis or infectious mononucleosis", "Viral disease is a recognized alternative when the presentation is not dominated by papillary necrosis. [16][18]", "Reassess lesion distribution and obtain targeted evaluation for the suspected viral syndrome. [16][18]" ], [ "Gonococcal or streptococcal gingivitis", "Bacterial gingivitis without the characteristic ANUG pattern remains a diagnostic alternative. [16][18]", "Use syndrome-directed infectious evaluation rather than routine ANUG lesion culture. [16][21]" ], [ "Desquamative gingivitis, erythema multiforme, or pemphigus vulgaris", "Diffuse desquamation, erosions, or mucocutaneous features are atypical for isolated ANUG. [16][18]", "Seek oral medicine, dermatology, or dental specialty evaluation for diagnostic confirmation. [16][18]" ] ] } }, { "id": "acute-management", "eyebrow": "Treatment", "heading": "Treat locally first and add systemic therapy for selected patients", "intro": "Prompt plaque disruption and removal of necrotic surface material are the core acute interventions.", "paragraphs": [ "Arrange superficial debridement, generally under local anesthesia when needed, as the acute procedural cornerstone. Acute management also includes oral-hygiene instruction and antimicrobial mouthwash; chlorhexidine, warm saltwater, or diluted hydrogen peroxide rinses are described local adjuncts. Reassess after acute inflammation improves for further debridement and comprehensive periodontal evaluation. [7][16]", "Use systemic antibiotics as an adjunct when the patient is immunocompromised or has systemic signs such as fever, malaise, or lymphadenopathy. Metronidazole or penicillin are described treatment options; an American Academy of Pediatrics reference similarly identifies debridement with penicillin or metronidazole as management. Available evidence does not establish a source-supported adult dosing regimen in this record, so coordinate agent selection and dosing with the treating dentist or oral specialist and patient-specific factors. [7][11][16]", "Provide analgesia sufficient to permit hydration, nutrition, and oral hygiene. Recommend rest, fluid intake, and a soft nutritious diet during the acute episode, and address tobacco exposure because recurrence prevention depends on restoring hygiene and reducing predisposing exposures. [7][16]" ], "bullets": [ "Do not substitute antibiotics for debridement and plaque-control measures; ANUG treatment is multifactorial and includes both local intervention and correction of predispositions. [16]", "Use chlorhexidine as a local adjunct where appropriate; it was used with metronidazole from the first day of hospitalization in a reported immunocompromised case. [3]", "After pain and acute inflammation recede, complete periodontal examination and additional debridement rather than ending care after initial symptom improvement. [7][16]", "If safe dental intervention is limited by severe cytopenias or systemic instability, manage in coordination with oncology, hematology, dentistry, and inpatient teams. [9]" ], "subsections": [ { "heading": "High-risk immunocompromised hosts", "paragraphs": [ "In patients with HIV, ANUG should trigger review of virologic and immunologic care and assessment for other HIV-associated oral disease; HIV infection does not itself preclude needed dental treatment, and modern antiretroviral therapy may normalize CD4+ and neutrophil counts in many patients. [5][16]", "For patients receiving chemotherapy, distinguish routine localized disease from rapidly progressive necrosis in the setting of severe neutropenia or thrombocytopenia. In the latter setting, procedural safety and antimicrobial strategy require hospital-based coordination because conventional debridement may be unsafe and oral disease may coexist with other septic foci. [9]" ], "bullets": [] } ], "table": { "caption": "Acute management components and when they apply. [3][7][9][11][16]", "columns": [ "Intervention", "When to use", "Operational point" ], "rows": [ [ "Superficial dental debridement", "Core acute treatment for clinically diagnosed ANUG. [16]", "Use local anesthesia when needed; plan further debridement after acute inflammation subsides. [7]" ], [ "Chlorhexidine or other local rinsing regimen", "Adjunct to debridement and hygiene measures. [7][16]", "Chlorhexidine was used with metronidazole on the first hospital day in a reported case. [3]" ], [ "Penicillin or metronidazole", "Adjunctive therapy for systemic signs or immunocompromise. [7][11][16]", "Coordinate patient-specific selection and dosing with the dental/oral specialist. [11][16]" ], [ "Hospital-based multidisciplinary management", "Rapid progression with severe neutropenia, thrombocytopenia, or systemic deterioration. [9]", "Balance debridement safety with urgent infection control and evaluation for sepsis. [9]" ] ] } }, { "id": "predisposition-and-prevention", "eyebrow": "Recurrence Prevention", "heading": "Correct the host and behavioral drivers after acute control", "intro": "Relapse prevention requires more than symptom resolution because untreated predisposing factors perpetuate necrotizing periodontal disease.", "paragraphs": [ "Review the exposure pattern that contributed to disease: poor oral hygiene, tobacco use, malnutrition, psychological stress, inadequate sleep, unsanitary living conditions, and immunocompromise are recognized predisposing factors. A focused plan should specify periodontal follow-up, daily plaque control, nutritional support when indicated, tobacco cessation, and management of systemic immunosuppression. [16][18][24]", "Maintain periodontal follow-up after the acute episode. The maintenance phase is intended to reinforce oral-hygiene adherence and control predisposing factors; relapse is likely when maintenance is not performed. [16]", "When ANUG occurs without an obvious local explanation, particularly in a young adult or patient with recurrent disease, evaluate for HIV and other causes of impaired host defense. ANUG is among oral manifestations recognized in HIV, and clinicians should consider it even with stable CD4+ counts. [5][12][13][16]" ], "bullets": [ "At follow-up, reassess bleeding, residual papillary architecture, pseudomembrane resolution, periodontal pocketing, tooth mobility, and ability to perform oral hygiene. [16][23]", "Reconsider the diagnosis if necrosis fails to resolve after adequate local treatment or if lesions evolve toward diffuse mucocutaneous erosions; viral, bacterial, and immune-mediated alternatives require different evaluation. [16][18]", "Continue dental care in patients with controlled HIV when otherwise clinically appropriate; HIV-positive and HIV-negative patients have shown comparable endodontic outcomes in cited studies. [5]" ], "subsections": [], "table": { "caption": "Predisposing factors that should trigger a documented prevention action. [5][16][18][24]", "columns": [ "Predisposition", "Clinical implication", "Follow-up action" ], "rows": [ [ "Poor oral hygiene", "Promotes the biofilm-associated disease environment. [16]", "Provide explicit plaque-control instruction and periodontal follow-up. [16]" ], [ "Tobacco use", "Recognized ANUG predisposition and relapse contributor. [16]", "Initiate tobacco-cessation counseling and reinforce oral-hygiene measures. [7][16]" ], [ "Stress, inadequate sleep, or malnutrition", "Associated host factors may contribute to disease susceptibility. [16][18][24]", "Address nutritional intake, sleep, and psychosocial stressors alongside dental care. [7][16]" ], [ "HIV or other immunocompromise", "Associated with ANUG and potentially more severe disease. [5][16]", "Review immune status and coordinate medical and dental management. [5][16]" ] ] } } ], "faq": [], "references": [ { "number": 1, "title": "Systematic scoping review of the noma evidence landscape", "detail": "gh.bmj.com", "url": "https://gh.bmj.com/content/10/7/e018023.full.pdf", "authors": "gh.bmj.com", "host": "gh.bmj.com" }, { "number": 2, "title": "Management of severe acute dental infections", "detail": "www.bmj.com", "url": "https://www.bmj.com/content/350/bmj.h1300/rapid-responses", "authors": "www.bmj.com", "host": "www.bmj.com" }, { "number": 3, "title": "Acute necrotising ulcerative gingivitis in an ...", "detail": "casereports.bmj.com", "url": "https://casereports.bmj.com/content/casereports/2015/bcr-2015-211092.full.pdf", "authors": "casereports.bmj.com", "host": "casereports.bmj.com" }, { "number": 4, "title": "Necrotising gingivitis and the dental team", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41407-024-2623-1", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 5, "title": "Expert consensus on endodontic therapy for patients with systemic conditions | International Journal of Oral Science", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41368-024-00312-0", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 6, "title": "Probiotics as an adjunctive therapy in periodontitis treatment—reality or illusion—a clinical perspective | npj Biofilms and Microbiomes", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41522-024-00614-5", "authors": "www.nature.com", "host": "www.nature.com" }, { "number": 7, "title": "Acute Necrotizing Ulcerative Gingivitis - 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Verify recommendations against current guidance and patient-specific factors.", "citations": [ { "number": 1, "title": "Systematic scoping review of the noma evidence landscape", "detail": "gh.bmj.com", "url": "https://gh.bmj.com/content/10/7/e018023.full.pdf", "authors": "gh.bmj.com", "host": "gh.bmj.com", "snippet": "in Kala-­ Azar Patients. Chin Med J 1949;67:469–73. 24 Siddiqui AZ, Vellappally S, Fouad H, et al. Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis. Photodiagnosis Photodyn Ther 2020;29:101668. 25 Chaubal T, Bapat R. Trench Mouth. Am J Med 2017;130:e", "score": 0.6698534 }, { "number": 2, "title": "Management of severe acute dental infections", "detail": "www.bmj.com", "url": "https://www.bmj.com/content/350/bmj.h1300/rapid-responses", "authors": "www.bmj.com", "host": "www.bmj.com", "snippet": "1. Periodontal abscess - The tooth is vital. Suppuration from the periodontal pocket is present. Pain is moderate when compared to abscesses of pulpal origin which usually are severe. Treatment of periodontal abscess includes incision and drainage of pus, scaling, root planing and systemic antibioti", "score": 0.44796792 }, { "number": 3, "title": "Acute necrotising ulcerative gingivitis in an ...", "detail": "casereports.bmj.com", "url": "https://casereports.bmj.com/content/casereports/2015/bcr-2015-211092.full.pdf", "authors": "casereports.bmj.com", "host": "casereports.bmj.com", "snippet": "by J Hu · 2015 · Cited by 36 — Empiric antibiotics on admission were metronidazole, metronidazole and chlorhexi- dine oral rinse on day one of hospitalisation. chlorhexidine", "score": 0.5809471 }, { "number": 4, "title": "Necrotising gingivitis and the dental team", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41407-024-2623-1", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "4. Scottish Dental Clinical Effectiveness Programme. Prevention and Treatment of Periodontal Diseases in Primary Care. Dental Clinical Guidance. 2 nd edition. February 2024. Available at: (accessed February 2024).\n\n5. Sangani I, Watt E, Cross D. Necrotizing ulcerative gingivitis and the orthodo", "score": 0.5550741 }, { "number": 5, "title": "Expert consensus on endodontic therapy for patients with systemic conditions | International Journal of Oral Science", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41368-024-00312-0", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "of AIDS/HIV infection such as tuberculous ulcer, oral candidiasis, hairy leukoplakia, Kaposi’s sarcoma, linear gingival erythema, and necrotizing ulcerative gingivitis. Further modifications to the treatment plan should be made based on the patient’s symptoms and overall conditions. To date, no stud", "score": 0.21842791 }, { "number": 6, "title": "Probiotics as an adjunctive therapy in periodontitis treatment—reality or illusion—a clinical perspective | npj Biofilms and Microbiomes", "detail": "www.nature.com", "url": "https://www.nature.com/articles/s41522-024-00614-5", "authors": "www.nature.com", "host": "www.nature.com", "snippet": "Periodontitis is a result of untreated gingivitis associated to bacterial plaque accumulation, and alteration of the marginal gum, bleeding on probing, and an irreversible periodontal attachment loss with formation of pockets and recessions, and bone resorption with tooth mobility and exfoliation. C", "score": 0.12535442 }, { "number": 7, "title": "Acute Necrotizing Ulcerative Gingivitis - an overview", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/acute-necrotizing-ulcerative-gingivitis", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "In the acute phase, patients typically are treated by débridement under local anesthesia. Rinsing with chlorhexidine, warm saltwater, or diluted hydrogen peroxide may be beneficial; also, adjunctive systemic antibiotics (such as metronidazole or amoxicillin) may be prescribed, particularly if the pa", "score": 0.8098936 }, { "number": 8, "title": "Gingivitis - an overview | ScienceDirect Topics", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/gingivitis", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Title: Gingivitis - an overview | ScienceDirect Topics\nClassifications include plaque-induced, non-plaque-induced, and then gingivitis secondary to medications and systemic diseases.15. There is a condition called acute necrotizing ulcerative gingivitis that includes a necrotic slough of the gingiva", "score": 0.6205532 }, { "number": 9, "title": "ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN ONCOPEDIATRIC PATIENTS: CHALLENGES IN TREATMENT - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S2212440322003807", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "Title: ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN ONCOPEDIATRIC PATIENTS: CHALLENGES IN TREATMENT - ScienceDirect\n## Article preview. ## Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Volume 134, Issue 3, September 2022, Page e147. # ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN ONCOPE", "score": 0.48294178 }, { "number": 10, "title": "Acute necrotizing ulcerative tonsillitis and gingivitis (Vincent's infections) - ScienceDirect", "detail": "www.sciencedirect.com", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0196064481802004", "authors": "www.sciencedirect.com", "host": "www.sciencedirect.com", "snippet": "## Article preview. ## Annals of Emergency Medicine. Volume 10, Issue 11, November 1981, Pages 593-595. # Case report Acute necrotizing ulcerative tonsillitis and gingivitis (Vincent's infections). Author links open overlay panel. )80200-480200-4 \"Persistent link using digital object identifier\")Get", "score": 0.4501424 }, { "number": 11, "title": "86: Common Oral Lesions", "detail": "publications.aap.org", "url": "https://publications.aap.org/aapbooks/book/672/chapter/8115211/Common-Oral-Lesions", "authors": "publications.aap.org", "host": "publications.aap.org", "snippet": "Acute necrotizing ulcerative gingivitis should be managed with débridement and penicillin or metronidazole. Vincent infection should be managed with", "score": 0.5637388 }, { "number": 12, "title": "HIV/AIDS", "detail": "iris.who.int", "url": "https://iris.who.int/bitstreams/66bf9949-3a6b-432f-b097-a2bfcc3625af/download", "authors": "iris.who.int", "host": "iris.who.int", "snippet": "by World Health Organization · 2005 · Cited by 85 — Acute necrotizing ulcerative gingivitis or stomatitis, or acute necrotizing ulcerative periodontitis Severe pain, ulcerated gingival papillae, loosening of", "score": 0.42677602 }, { "number": 13, "title": "Presumptive and definitive criteria for recognizing HIV- ...", "detail": "iris.who.int", "url": "https://iris.who.int/bitstreams/d8a548fc-d741-4f13-a6fc-1f06dab13b84/download", "authors": "iris.who.int", "host": "iris.who.int", "snippet": "by World Health Organization · 2013 · Cited by 10540 — Acute necrotizing ulcerative gingivitis or stomatitis, Severe pain, ulcerated gingival papillae, loosening of teeth, spontaneous bleeding, bad odour and rapid", "score": 0.37710527 }, { "number": 14, "title": "Stomatitis (Chapter 335)", "detail": "publications.aap.org", "url": "https://publications.aap.org/pediatriccare/book/348/chapter/5787217/Stomatitis-Chapter-335", "authors": "publications.aap.org", "host": "publications.aap.org", "snippet": "The bacterial condition necrotizing ulcerative gingivitis is characterized by painful, erythematous, and friable gingiva. Foul breath accompanies the necrotic", "score": 0.36378303 }, { "number": 15, "title": "Oral health for the 21st Century", "detail": "iris.who.int", "url": "https://iris.who.int/bitstream/handle/10665/61431/WHO_ORH_ORALC21.94.1.pdf?sequence=1", "authors": "iris.who.int", "host": "iris.who.int", "snippet": "by World Health Organization · 1994 · Cited by 24 — Necrotizing Ulcerative Gingivitis (NUG) to noma or cancrum oris. Associated with oral mucosal diseases, salivary gland dysfunction forms an important area", "score": 0.2951542 }, { "number": 16, "title": "Acute Necrotizing Ulcerative Gingivitis - StatPearls - NCBI Bookshelf", "detail": "www.ncbi.nlm.nih.gov", "url": "https://www.ncbi.nlm.nih.gov/books/NBK562243", "authors": "www.ncbi.nlm.nih.gov", "host": "www.ncbi.nlm.nih.gov", "snippet": "## Differential Diagnosis\n\nANUG may be mistaken for other infectious or inflammatory conditions. Considerations for a differential diagnosis should include bacterial causes, such as gonococcal or streptococcal gingivitis, and viral causes, such as acute herpetic gingivostomatitis and infectious mono", "score": 0.6989468 }, { "number": 17, "title": "Acute Necrotizing Ulcerative Gingivitis: A Case Report - PMC", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11268974", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "by M Gollapudi · 2024 · Cited by 7 — The diagnosis is mainly based on clinical findings, namely, the presence of interdental papilla necrosis pain, pseudomembranous formation", "score": 0.65173227 }, { "number": 18, "title": "Necrotizing Ulcerative Gingivitis", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5644015", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "The microbiota composition associated with NUG and found in lesion layers includes _Treponema_ spp., _Selenomonas_ spp., _Fusobacterium_ spp., and _Prevotella intermedia_. Other microorganisms have also been described, although these were defined as “variable” flora and were not present in all cases", "score": 0.6194488 }, { "number": 19, "title": "Acute Necrotizing Ulcerative Gingivitis", "detail": "pubmed.ncbi.nlm.nih.gov", "url": "https://pubmed.ncbi.nlm.nih.gov/32965914", "authors": "pubmed.ncbi.nlm.nih.gov", "host": "pubmed.ncbi.nlm.nih.gov", "snippet": "by SL Aaron · 2025 · Cited by 23 — Acute necrotizing ulcerative gingivitis (ANUG) is a rare, severe infection of the gum tissue, affecting less than 1% of the population.", "score": 0.58465123 }, { "number": 20, "title": "Acute necrotizing ulcerative gingivitis-periodontitis", "detail": "pubmed.ncbi.nlm.nih.gov", "url": "https://pubmed.ncbi.nlm.nih.gov/9597852", "authors": "pubmed.ncbi.nlm.nih.gov", "host": "pubmed.ncbi.nlm.nih.gov", "snippet": "by DN Wade · 1998 · Cited by 49 — Acute necrotizing ulcerative gingivitis-periodontitis (ANUG/NUP) is a relatively uncommon periodontal disease characterized by gingival necrosis and ulceration", "score": 0.57952 }, { "number": 21, "title": "A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology - PMC", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7108105", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "| Etiologic Agents | Diagnostic Procedures | Optimum Specimens | Transport Issues and Optimal Transport Time |\n --- --- |\n| Vincent angina (acute necrotizing ulcerative gingivitis) |\n| Mixed infection due to Fusobacterium spp and commensal Borrelia spp of the oral cavity | Gram stain; culture not r", "score": 0.55478466 }, { "number": 22, "title": "Acute necrotizing ulcerative gingivitis. A review of diagnosis ...", "detail": "pubmed.ncbi.nlm.nih.gov", "url": "https://pubmed.ncbi.nlm.nih.gov/3514841", "authors": "pubmed.ncbi.nlm.nih.gov", "host": "pubmed.ncbi.nlm.nih.gov", "snippet": "In addition to the historic association of fusiform and spirochete microbes with ANUG, recent findings have also implicated Bacteroides and Selenomonas species.", "score": 0.49992734 }, { "number": 23, "title": "Necrotizing Ulcerative Gingivitis, a Rare Manifestation as a ...", "detail": "pmc.ncbi.nlm.nih.gov", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8481045", "authors": "pmc.ncbi.nlm.nih.gov", "host": "pmc.ncbi.nlm.nih.gov", "snippet": "by M Damdoum · 2021 · Cited by 3 — Radiographically, bone loss can be observed around the teeth and implants divided according to quadrants of the mouth.", "score": 0.35267037 }, { "number": 24, "title": "Necrotizing ulcerative gingivitis, periodontitis, and stomatitis", "detail": "pubmed.ncbi.nlm.nih.gov", "url": "https://pubmed.ncbi.nlm.nih.gov/8558402", "authors": "pubmed.ncbi.nlm.nih.gov", "host": "pubmed.ncbi.nlm.nih.gov", "snippet": "by GM Horning · 1995 · Cited by 239 — Beside HIV infection, significant predisposing factors included poor oral hygiene, unusual life stress, inadequate sleep, Caucasian race, age 18 to 21 years,", "score": 0.25250426 } ], "publishedAt": "2026-08-24T17:02:19.025476+00:00", "updatedAt": "2026-08-24T17:02:19.025476+00:00", "readingMinutes": 5, "slug": "acute-necrotizing-ulcerative-gingivitis" }